Formation of Normal Gingival Epithelial Phenotypes Around Osseo‐Integrated Oral Implants in Humans

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141694/1/jper0933.pd

Trochanteric locking nail versus arthroplasty in unstable intertrochanteric fracture in patients aged over 75 years

SummaryIntroductionIn trochanteric fracture, whatever its anatomic type, internal fixation is currently the standard attitude, with arthroplasty as a relatively unusual option.HypothesisHip implants are an excellent alternative to osteosynthesis in unstable trochanteric fracture in patients aged over 75 years.Patients and methodsA non-randomised prospective multicenter study compared osteosynthesis by trochanteric nailing (n=113) to hip arthroplasty (n=134) in unstable trochanteric fracture (AO types 31 A2.2 and 3 and A3.3) in 247 patients over the age of 75 years. The series was recruited during 2007 in seven centres, four of which included only arthroplasties, two only osteosyntheses and one both. The two groups were comparable in age, sex, preoperative Parker score, pre-fracture place of residence, fracture type, time to surgery and preoperative comorbidity. The sole difference was in operators, with more senior surgeons in arthroplasty (62% versus 27%).ResultsThree-month mortality was identical in the two groups (21.2% versus 21%). General complications did not differ, although mechanical complications were more frequent in the nailing group (12.5% versus 2.8%). Functional results (Parker and PMA scores) were better in the implant than in the nail group.DiscussionThe present study validated hip arthroplasty in these indications. Cemented stems associated to a dual-mobility acetabular component gave the best results.Type of studyProspective, level of evidence III

Stable transfection of protein kinase C alpha cDNA in hormone-dependent breast cancer cell lines

An inverse relationship between protein kinase C (PKC) activity and oestrogen receptor (ER) expression in human breast cell lines and tumours has been firmly established over the past 10 years. To determine whether specific alterations in PKC expression accompany hormone-independence, we examined the expression of PKC isozymes in the hormone-independent human breast cancer cell clones MCF-7 5C and T47D:C42 compared with their hormone-dependent counterparts, MCF-7 A4, MCF-7 WS8 and T47D:A18 respectively. Both hormone-independent cell clones exhibit elevated PKCα expression and increased basal AP-1 activity compared with the hormone-dependent cell clones. To determine whether PKCα overexpression is sufficient to mediate the hormone-independent phenotype, we stably transfected an expression plasmid containing PKCα cDNA to the T47D:A18 and MCF-7 A4 cell lines. This is the first report of PKCα transfection in T47D cells. In contrast to MCF-7 cells, T47D has the propensity to lose the ER and more readily forms tamoxifen-stimulated tumours in athymic mice. We find that in T47D:A18/PKCα clones, there is concomitant up-regulation of PKC βI and δ, whereas in the MCF-7 A4/PKCα transfectants PKC ɛ is up-regulated. In T47D:A18, but not in MCF-7 A4, PKCα stable transfection is accompanied by down-regulation of ER function whilst basal AP-1 activity is elevated. Our results suggest PKCα overexpression may play a role in growth signalling during the shift from hormone dependent to hormone-independent breast cancers. © 2000 Cancer Research Campaig

Studies of adsorbents and pressure/vacuum swing adsorption for co2 capture

The capture of carbon dioxide via Pressure/Vacuum Swing Adsorption (PSA/VPSA) has been examined experimentally and mathematically. The adopted method was a two bed/four step process, known as the Skarstrom Cycle. Pelletised and calcined SBA-15 powder has been modified with a monoamine, a diamine and a triamine and has been tested in a PSA configuration. The performance of the monoamine modified SBA-15 was more than doubled with the presence of immobilised polyamine groups (diamine/triamine modified SBA-15) extending the adsorption capacity of the material (chemisorption), but still not comparable to the performance of zeolite 13X (physisorption) in terms of performance, stability and reproducibility. These results will be compared to the performance of four Metal Organic Frameworks, ZIF-8, ZIF-67, UiO-66 and CuBTC which are innovative and promising materials with several applications. Experimentally, the performance of zeolites and amine modified mesoporous silicas has been investigated for different experimental conditions (cycle time, pressure ratio, feed/purge ratio). This work is further supported by theoretical studies of PSA which employs a mathematical model based on linear coupled macropore and micropore diffusion and, where appropriate, reaction. These simulations are performed using gProms

EO-Alert: A Satellite Architecture for Detection and Monitoring of Extreme Events in Real Time

This paper presents the architecture and results achieved by the EO-ALERT H2020 project. EO-ALERT proposes the definition and development of the next-generation Earth Observation (EO) data processing chain, based on a novel flight segment architecture that moves optimised key EO data processing elements from the ground segment to onboard the satellite, with the aim of delivering the EO products to the end user with very low latency (in almost real-time). This paper presents the EO-ALERT architecture, its performance and hardware. Performances are presented for two reference user scenarios; ship detection and extreme weather nowcasting/monitoring. The hardware testing results show that, when implemented using Commercial Off-The-Shelf (COTS) components and available communication links, the proposed architecture can deliver EO products and alerts to the end user with a latency lower than one-point-five minutes, for both SAR and Optical Very High Resolution (VHR) missions, demonstrating the viability of the EO-ALERT concept and architecture