Sensitizing Efficiency of Some Added Metal Salts on the Thermal and Explosive Characteristics of Hydrazenium Monoperchlorate and Hydrazenium Diperchlorate

Sensitivity to heat, impact and friction of hydrazenium-monoperchlorate and hydrazenium-diperchlorate have been investigated and the sensitizing efficiency of some added metal salts evaluated. The thermal sensitizing efficiency of the additives follow the order CuCrO/sub 4/ > CuCl/sub 2/ >NiO > Fe/sub 2/O/sub 3/ > MgO. The activation energy values obtained from explosion delay time are comparable with the values reported for thermal decomposition studies and are close to the activation energy value for thermal decomposition studies and are close to the activation energy value for thermal decomposition of anhydrous perchloric acid. The F of I values for these compounds are in the range reported for common initiatory explosives and are of the same order as that for mercury fulminate

Complexes of Cu(II) & Hg(II) with 1,3-Diamino- & 1,4-Diamino- benzenes

357-35

Adaptation in P300 braincomputer interfaces: A two-classifier cotraining approach

10.1109/TBME.2010.2058804IEEE Transactions on Biomedical Engineering57122927-2935IEBE

Numerical Simulation of Diffuser of a Gas Turbine using the Actuator Disc Model

An analysis of the exhaust diffuser section of a gas turbine is presented by incorporating the reduced order mathematical model “actuator disc concept” that represents the last stage of the turbine. The actuator disc model is one of the simplified numerical methods for analyzing the aerodynamic performance of axial turbine stage. In which, the rotor and the stator of the turbine stages are modeled as zero thickness discs with a specified blade speed and zero speed respectively. Finite volume based commercial CFD package ANSYS FLUENT was employed for the numerical investigation of the applicability of the proposed simplified model. The compressible Navier-Stoke equations along with k- turbulent model were solved in the computational domain by incorporating suitable boundary conditions. The implementation of actuator disc boundary conditions is described in detail. The numerical results obtained from the proposed model are in good agreement with the experimental data available in the literature. The effect of casing angle on the performance of diffuser is presented

In silico and in vitro validation of some benzimidazole derivatives as adenosine deaminase inhibitors

1175-1182Benzimidazole nucleus considered as an important scaffold for developing drug candidates against a wide spectrum of diseases. Adenosine deaminase (ADA), an enzyme present in purine metabolic pathway, has a significant role in inflammatory and malignant diseases and hence it is considered as a major target for drug development. The present study investigates ADA inhibitory potential of selected benzimidazole derivatives by using in silico and in vitro methods. Molecular docking and dynamics simulations have been carried out to identify potential ADA activesite binders from benzimidazole derivatives. Compounds having strong binding affinities were selected for enzyme inhibition assays and fluorescent binding studies. The results showed that the pyridinyl and butyl derivatives of benzimidazole possess significant ADA inhibitory potential.The study proposes these compounds can be used as potent candidates for developing ADA inhibitor drugs

In silico and in vitro validation of some benzimidazole derivatives as adenosine deaminase inhibitors

Benzimidazole nucleus considered as an important scaffold for developing drug candidates against a wide spectrum of diseases. Adenosine deaminase (ADA), an enzyme present in purine metabolic pathway, has a significant role in inflammatory and malignant diseases and hence it is considered as a major target for drug development. The present study investigates ADA inhibitory potential of selected benzimidazole derivatives by using in silico and in vitro methods. Molecular docking and dynamics simulations have been carried out to identify potential ADA activesite binders from benzimidazole derivatives. Compounds having strong binding affinities were selected for enzyme inhibition assays and fluorescent binding studies. The results showed that the pyridinyl and butyl derivatives of benzimidazole possess significant ADA inhibitory potential.The study proposes these compounds can be used as potent candidates for developing ADA inhibitor drugs

A thermostatically controlled miniature glass-house

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