THE EFFECT OF KINETIC MECHANISM AND TURBULENCE ON THE COMBUSTION PROCESS

Abstract The modelisation of combustion is central problem in most practical combustion system. In this work, turbulent combustion is discussed with a lagrangian model, which is useful for the study of turbulent combustion problem. A coupling between this lagrangian model and the presumed probability density function (pdf) method is used with complex chemistry. The validation of the kinetic mechanism was envisaged before integrated it in the computer code for reciprocating engines. The results of computations with the present models are compared with the experimental results obtained from experience obtained in our laboratory and from PSA (Peugeot -Citroen) engine. The comparisons between the results of the modeling and the experiments showed a good agreement

Chromosomal contacts connect loci associated with autism, BMI and head circumference phenotypes

Copy number variants (CNVs) are major contributors to genomic imbalance disorders. Phenotyping of 137 unrelated deletion and reciprocal duplication carriers of the distal 16p11.2 220 kb BP2-BP3 interval showed that these rearrangements are associated with autism spectrum disorders and mirror phenotypes of obesity/underweight and macrocephaly/microcephaly. Such phenotypes were previously associated with rearrangements of the non-overlapping proximal 16p11.2 600 kb BP4-BP5 interval. These two CNV-prone regions at 16p11.2 are reciprocally engaged in complex chromatin looping, as successfully confirmed by 4C-seq, fluorescence in situ hybridization and Hi-C, as well as coordinated expression and regulation of encompassed genes. We observed that genes differentially expressed in 16p11.2 BP4-BP5 CNV carriers are concomitantly modified in their chromatin interactions, suggesting that disruption of chromatin interplays could participate in the observed phenotypes. We also identified cis- and trans-acting chromatin contacts to other genomic regions previously associated with analogous phenotypes. For example, we uncovered that individuals with reciprocal rearrangements of the trans-contacted 2p15 locus similarly display mirror phenotypes on head circumference and weight. Our results indicate that chromosomal contacts’ maps could uncover functionally and clinically related genes.Molecular Psychiatry advance online publication, 31 May 2016; doi:10.1038/mp.2016.84

Homozygous NLRP7 mutations in a Moroccan woman with recurrent reproductive failure.

International audienc

Discordant sex in monozygotic XXY/XX twins: a case report

International audienc

Hydrometry and standardization

Normalization allows to define a common language among the actors in a particular field, to clarify, to harmonize practices and to define the level of quality, safety and less environmental impact of practices. In France, in the field of hydrometry, the normalization work is carried out by the AFNOR / X10C commission. After several years of inactivity, the commission was recently reactivated two years ago, under the impulse of a few motivated actors. The objective of this paper is to highlight the added value of standardization in the hydrometry activity, through a few concrete examples of standards. The organization of standardization at national and international level may seem complex. A presentation of the different standardization structures is therefore proposed, as well as the process of developing a standard

A new autoinflammatory and autoimmune syndrome associated with NLRP1 mutations: NAIAD (NLRP1-associated autoinflammation with arthritis and dyskeratosis)

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Charte qualité de l'hydrométrie. Guide de bonnes pratiques

La première édition en 1998 de la charte qualité de l'hydrométrie, fruit du travail collectif de ces passionnés, avait tenu toutes ses promesses : outil destiné aux praticiens, ce guide des bonnes pratiques s'est rapidement révélé un véritable ouvrage de référence. L'idée d'une nouvelle édition s'est imposée comme une évidence. Aussi visionnaire qu'ait été la première édition, les innovations qu'elle décrivait sont, en moinsde vingt ans, devenues des outils quotidiens et en quelques années les pratiques se sont considérablement enrichies et de nouvelles pistes se sont ouvertes. Cette édition renouvelle l'exploit de la première : être àla fois un guide pratique pour les équipes de terrain et un manuel de référence méthodologique parfaitement documenté, à la pointe des connaissances, qui satisfera les spécialistes les plus exigeants. Par cette qualité, cet ouvrage est le meilleur manifeste que l'on puisse imaginer pour promouvoir cette discipline et encourager les jeunes vocations à se tourner vers cette aventure : nos Tazieff et nos Cousteau de la prochaine génération ne seront-ils pas à l'évidence hydromètres