Beyond the IT Magic Bullet: HIV Prevention Education and Public Policy

Analytic applications are vital in the assessments of public health and surveillance as these applications can drive resource allocation, community assessment and public policy. Using a dataset of nearly 90,000 patient hospital encounters, the number of instances with an ICD code of HIV and co-morbidities was identified. Blacks accounted for 75 percent of HIV hospital encounters in the dataset. While business analytic applications informed this study of cross-tabulations and interaction effects among race, age and gender, there appears to be a significant relationship among HIV diagnoses and substance abuse. Payer data is informed by the Healthcare Cost and Utilization Project (HCUP), and these findings indicate significant service utilization among those insured by Medicare. More importantly, these issues raise more salient implications among the current health and public policy among HIV care delivery, in general, and among the Black community, in particular. Attention to health and public policy warrants further investigation given that this discourse has shifted to a focus on curvative medicine and away from prevention and education

BODY ROLL: WHAT WE NOW KNOW

This presentation will discuss the importance of body roll in competitive swimming. It will critically evaluate the scientific evidence supporting the potential benefits associated with body roll and provide some practical recommendations for coaches. When swimmers rotate about their longitudinal axis in the front crawl and backstroke, this is commonly referred to as body roll. This rolling movement is considered an essential component of these two strokes. Body roll ocurs as a consequence of the asymmetrical movements of the lower and upper limbs, and gravitational effects. Studies have shown that the shoulders and hips do not roll as one unit and that the timing and the magnitude of hip and shoulder roll depends on a number of factors including the swimmer’s speed, stroke rate, kick technique, breathing action and skill level. The key findings from these studies will be presented and their relevance to coaching discussed. There is some speculation that body roll can enhance the amount of propulsion created during front crawl swimming. Several studies have attempted to quantify the relationship between body roll and the underwater actions of the swimmer’s arm, shedding some light on the possible links between body roll and propulsion. The implications of this research for coaching will be discussed. It seems likely that body roll would have a considerable influence on the amount of hydrodynamic drag experienced by swimmers, although the precise nature of this influence is unclear. The potential links between body roll and drag will be addressed. Swimmers can reduce the risk of shoulder impingement injury by altering their stroke mechanics. One of the most common recommendations given to front crawl swimmers that suffer from impingement syndrome is to increase the amount of body roll they use. The scientific evidence supporting the proposed link between body roll and shoulder impingement will be discussed

STROKE PARAMETERS AND ARM COORDINATION IN COMPETITIVE UNILATERAL ARM AMPUTEE FRONT CRAWL SWIMMERS

The aims of this study were to: (1) determine the changes in stroke parameters and arm coordination as a function of swimming speed; and (2) examine the relationships between stroke parameters and arm coordination, for competitive unilateral arm amputee front crawl swimmers. Thirteen highly-trained swimmers (3 male, 10 female) were filmed underwater from lateral views during six increasingly faster 25 m front crawl trials. Increases in swimming speed were achieved by an increase in stroke frequency which coincided with a decrease in stroke length. All swimmers showed asymmetric coordination between their affected and unaffected arm pulls, which was not affected by an increase in swimming speed up to maximum. The fastest amputee swimmers used higher stroke frequencies and less catch-up coordination before their affected arm pull, when compared to the slower swimmers. Reducing the time delay before initiating the affected arm pull appears to be beneficial for successful swimming performance

A National Dialogue on Health Information Technology and Privacy

Increasingly, government leaders recognize that solving the complex problems facing America today will require more than simply keeping citizens informed. Meeting challenges like rising health care costs, climate change and energy independence requires increased level of collaboration. Traditionally, government agencies have operated in silos -- separated not only from citizens, but from each other, as well. Nevertheless, some have begun to reach across and outside of government to access the collective brainpower of organizations, stakeholders and individuals.The National Dialogue on Health Information Technology and Privacy was one such initiative. It was conceived by leaders in government who sought to demonstrate that it is not only possible, but beneficial and economical, to engage openly and broadly on an issue that is both national in scope and deeply relevant to the everyday lives of citizens. The results of this first-of-its-kind online event are captured in this report, together with important lessons learned along the way.This report served as a call to action. On his first full day in office, President Obama put government on notice that this new, more collaborative model can no longer be confined to the efforts of early adopters. He called upon every executive department and agency to "harness new technology" and make government "transparent, participatory, and collaborative." Government is quickly transitioning to a new generation of managers and leaders, for whom online collaboration is not a new frontier but a fact of everyday life. We owe it to them -- and the citizens we serve -- to recognize and embrace the myriad tools available to fulfill the promise of good government in the 21st Century.Key FindingsThe Panel recommended that the Administration give stakeholders the opportunity to further participate in the discussion of heath IT and privacy through broader outreach and by helping the public to understand the value of a person-centered view of healthcare information technology

Failure of the ERBE scanner instrument aboard NOAA 10 spacecraft and results of failure analysis

The Earth Radiation Budget Experiment (ERBE) scanner instrument on the NOAA 10 spacecraft malfunctioned on May 22, 1989, after more than 4 years of in-flight operation. After the failure, all instrument operational mode commands were tested and the resulting data analyzed. Details of the tests and analysis of output data are discussed therein. The radiometric and housekeeping data appear to be valid. However, the instrument will not correctly execute operational scan mode commands or the preprogrammed calibration sequences. The data indicate the problem is the result of a failure in the internal address decoding circuity in one of the ROM (read only memory) chips of the instrument computer

Novel cell adhesion/migration pathways are predictive markers of HDAC inhibitor resistance in cutaneous T cell lymphoma

BACKGROUND: Treatment for Cutaneous T Cell Lymphoma (CTCL) is generally not curative. Therefore, selecting therapy that is effective and tolerable is critical to clinical decision-making. Histone deacetylase inhibitors (HDACi), epigenetic modifier drugs, are commonly used but effective in only ~30% of patients. There are no predictive markers of HDACi response and the CTCL histone acetylation landscape remains unmapped. We sought to identify pre-treatment molecular markers of resistance in CTCL that progressed on HDACi therapy. METHODS: Purified T cells from 39 pre/post-treatment peripheral blood samples and skin biopsies from 20 patients were subjected to RNA-seq and ChIP-seq for histone acetylation marks (H3K14/9 ac, H3K27ac). We correlated significant differences in histone acetylation with gene expression in HDACi-resistant/sensitive CTCL. We extended these findings in additional CTCL patient cohorts (RNA-seq, microarray) and using ELISA in matched CTCL patient plasma. FINDINGS: Resistant CTCL exhibited high levels of histone acetylation, which correlated with increased expression of 338 genes (FDR \u3c 0·05), including some novel to CTCL: BIRC5 (anti-apoptotic); RRM2 (cell cycle); TXNDC5, GSTM1 (redox); and CXCR4, LAIR2 (cell adhesion/migration). Several of these, including LAIR2, were elevated pre-treatment in HDACi-resistant CTCL. In CTCL patient plasma (n = 6), LAIR2 protein was also elevated (p \u3c 0·01) compared to controls. INTERPRETATION: This study is the first to connect genome-wide differences in chromatin acetylation and gene expression to HDACi-resistance in primary CTCL. Our results identify novel markers with high pre-treatment expression, such as LAIR2, as potential prognostic and/or predictors of HDACi-resistance in CTCL. FUNDING: NIH:CA156690, CA188286; NCATS: WU-ICTS UL1 TR000448; Siteman Cancer Center: CA091842

cis-regulatory circuits regulating NEK6 kinase overexpression in transformed B cells Are super-enhancer independent

Alterations in distal regulatory elements that control gene expression underlie many diseases, including cancer. Epigenomic analyses of normal and diseased cells have produced correlative predictions for connections between dysregulated enhancers and target genes involved in pathogenesis. However, with few exceptions, these predicted cis-regulatory circuits remain untested. Here, we dissect cis-regulatory circuits that lead to overexpression of NEK6, a mitosis-associated kinase, in human B cell lymphoma. We find that only a minor subset of predicted enhancers is required for NEK6 expression. Indeed, an annotated super-enhancer is dispensable for NEK6 overexpression and for maintaining the architecture of a B cell-specific regulatory hub. A CTCF cluster serves as a chromatin and architectural boundary to block communication of the NEK6 regulatory hub with neighboring genes. Our findings emphasize that validation of predicted cis-regulatory circuits and super-enhancers is needed to prioritize transcriptional control elements as therapeutic targets

Evaluating the Quality of Physical Education Programs Provided by State Department of Education Websites and the Relationships Between Adolescent Obesity and Sedentary Prevalence

This research seeks to determine the relationships between the quality of physical education (PE) programs provided by state departments of education (DOE), obesity rates, and sedentary behaviors described as physical inactivity in adolescents ages 10-17 years old. A modified rubric based on the “Let’s Move Active Schools Assessment” was created and used to quantitatively and qualitatively evaluate the PE programs and physical activity (PA) opportunities provided by websites of the state’s DOE. A total of fourteen states were chosen to be assessed due to having either the highest or lowest obesity or physical inactivity rates. It was believed that the states with the highest obesity prevalence would have the highest inactivity and the lowest quality PE programs, and that those with lowest obesity prevalence would have lowest physical inactivity and high quality PE programs. After assessing the chosen states, no correlation was found between the quality of PE program as determined from the created rubric and the obesity or sedentary behavior rates of the state. The highest grade of all states assessed was 23 out of 27 with the lowest score being 7. The average scores of the states with the highest obesity was greater than the average for those states with the lowest inactivity, indicating that the quality of PE programs as provided by the DOE are not exclusively related to obesity and physical inactivity prevalence. Other determining factors such as nutrition, state funding, local policies, and societal factors may be more involved in the health of children than what is popularly believed. The data show that efforts are being made to decrease obesity throughout schools and the departments of education, however the efficiency of such efforts to increase physical activity and health are low. While states may post plans for PE and create standards for teaching, local levels of education are not required to enforce the policies or teach the curriculum suggested. Including students with special conditions and providing physical activities outside the school building is also lacking although it may seem like measures are being taken to provide such opportunities. More evaluations must be completed to get a stronger understanding of how to fix inadequate physical education and activity programs provided by the states’ DOEs. Reviewing each DOE efforts as well as that of the community and individual school districts would help gain insight into where roadblocks reside and how to overcome destructive policies to offer better physical activity and education to children

Front crawl arm stroke trajectories of physically impaired swimmers: A preliminary study

© 2019 Elsevier Masson SAS. Introduction: This study evaluated three-dimensional kinematic parameters of the front crawl stroke in physically impaired swimmers across a range of functional classification levels. Facts and Results: Eight highly-trained competitive swimmers (5 male and 3 female) from IPC classes S5 to S9 performed 50 m maximal front crawl trials while being video-taped by six cameras (four under- and two above water). The most distal point of the right upper limb was manually digitised at 50 Hz to allow three-dimensional reconstruction of the limb's trajectory through the water. Conclusion: The stroke presented large inter-swimmer variability, reflecting individual characteristics and severity of the impairment. The swimmers who combined shallow and narrow stroke movements produced a shorter trajectory. This study provides swimmers and coaches with an overview of the kinematic characteristics of a range of physically impaired swimmers