1,910 research outputs found

    Role of chloride in hot salt stress-corrosion cracking of titanium-aluminum alloys

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    Role of chloride in hot salt stress corrosion cracking of titanium-aluminum alloy

    Stress corrosion cracking of titanium alloys progress report, apr. 1 - jun. 30, 1964

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    Hot salt stress corrosion cracking in titanium alloys - chloride corrosion role determination using chlorine isotopes and relation between crack morphology and alloy structur

    Databook for human factors engineers. Volume 2 - Common formulas, metrics, definitions

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    Human factors engineering manual including mathematical formulas, nomographs, conversion tables, units of measurement, and nomenclature

    Ground Waves Generated by Pile Driving, and Structural Interaction

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    Pre-formed steel or concrete pile elements are installed by high energy impact or vibro-driver, which causes outgoing ground waves. In severe cases, adjacent buildings are at risk of damage. Assessment of risk is conventionally by reference to threshold limits of vibration. The global approach considers neither the interactive effects between ground and structure, nor frequency and duration. Here, firstly, the dynamics of a pile head impact and of the transmission of a portion of the energy into the ground were modelled by a combination of finite elements (FE), springs and dashpots. The boundary disturbances were then applied to a second model of the soil as an elastic half space. This outer model was constructed of axisymmetric finite and infinite elements for calibration against on-site measurements. The infinite elements (IE) represented a wider zone, and avoided spurious wave reflections at boundaries. Next, the verified ground disturbances adjacent to the pile were used as input to a three-dimensional FE/IE wedge-shaped model of a ‘slice’ of the axisymmetric system. Various structural forms, of steel frame structures and of brick walls, were added, giving a dynamic soil-structure analysis. Results show the responses of flexible and stiff structures to outgoing waves caused by impact pile driving and vibro-driving

    Comparison of the RNA-amplification based methods RT–PCR and NASBA for the detection of circulating tumour cells

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    Increasingly, reverse transcriptase polymerase chain reaction (RT–PCR) is used to detect clinically significant tumour cells in blood or bone marrow. This may result in a redefinition of disease-free and clinical relapse. However, its clinical utility may be limited by lack of automation or reproducibility. Recent studies have suggested nucleic acid sequence-based amplification of target RNA may be more robust. In this study, nucleic acid sequence-based amplification was established to detect melanoma, colorectal and prostate cancer cells. Nucleic acid sequence-based amplification and RT–PCR both successfully amplified target RNA in peripheral blood samples from patients with melanoma and colorectal cancer, but only RT–PCR detected PSA in blood samples from patients with prostate cancer. There was relatively good agreement between sample replicates analyzed by RT–PCR (Kappa values of one for tyrosinase, 0.67 for CK-20 and one for PSA), but less agreement when analyzed by nucleic acid sequence-based amplification. This may limit the routine use of NASBA for the detection of clinically significant disease. In summary, RT–PCR appears at present to be the most reliable and reproducible method for the detection of low-level disease in cancer patients, although prospective studies are warranted to assess the clinical utility of different molecular diagnostic methods
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