Reconstructing the Earthquake Recurrence Pattern in the Central Himalaya: Evidence from the Himalayan Frontal Thrust

Abstract HKT-ISTP 2013 A

Dynamic Analysis of HSDB System and Evaluation of Boundary Non-linearity through Experiments

This paper deals with mechanical design and development of high speed digital board (HSDB) system which consists of printed circuit board (PCB) with all electronic components packaged inside the cavity for military application. The military environment poses a variety of extreme dynamic loading conditions, namely, quasi static, vibration, shock and acoustic loads that can seriously degrade or even cause failure of electronics. The vibrational requirement for the HSDB system is that the natural frequency should be more than 200 Hz and sustain power spectrum density of 14.8 Grms in the overall spectrum. Structural integrity of HSDB is studied in detail using finite element analysis (FEA) tool against the dynamic loads and configured the system. Experimental vibration tests are conducted on HSDB with the help of vibration shaker and validated the FE results. The natural frequency and maximum acceleration response computed from vibration tests for the configured design were found. The finite element results show a good correlation with the experiment results for the same boundary conditions. In case of fitment scenario of HSDB system, it is observed that the influence of boundary non-linearity during experiments. This influence of boundary non-linearity is evaluated to obtain the closeout of random vibration simulation results

DOCKING ANTIOXIDANT ACTIVITY ON HYDROXY (DIPHENYL) ACETICACID AND ITS DERIVATIVES

Objectives: The antioxidant activity of the synthesized compounds along with the standard compound for comparison is reported. There is comparison of binding analysis and the ligand interaction of the compound. Methods: The protein crystal structure complexed with 4-methyl-6-[2-(5-morpholin-4-ylpyridin-3-yl)ethyl]pyridin-2-amine inhibitor was selected from Protein Data Bank (5FVP) for our study. Results: The docking studies and structure-activity relationship reveals that the compound 2'-chloro-4-methoxy-3nitro benzilic acid after three different docking strategies reveals that the score was found to be higher compared with others.Conclusion: Based on the in vitro antioxidant results, the compounds synthesized were investigated for the molecular docking study to identify the amino acid interactions in the active site pocket of nitric oxide synthase enzyme. Based on the docking score results, all the compounds were oriented toward the active site pocket occupied by the cocrystallized ligan

The Role of Diet in the Treatment of Pulmonary Tuberculosis: An Evaluation in a Controlled Chemotherapy Study in Home and Sanatorium Patients in South India

Before the advent of antituberculosis chemotherapy, a diet rich in calories, proteins, fats, minerals and vitamins was generally considered to be an important, if not essential, factor in the treatment of tuberculosis. The introduction of specific antituberculosis drugs, however, has so radically altered the management of the disease that the role of diet has to be reconsidered in the light of the recent advances in treatment. An evaluation of the influence of diet in the treatment of pulmonary tuberculosis with isoniazid plus p-aminosalicylic acid was recently undertaken by the Tuberculosis Chemotherapy Centre, Madras, in the course of a controlled comparison of home and sanatorium chemotherapy for tuberculous patients from a poverty-stricken community in Madras City. Despite the fact that during the year of treatment the home patients subsisted on a markedly poorer diet, were physically more active and, on the average, gained less weight than the sanatorium patients, the overall response to treatment in the home series closely approached that in the sanatorium series, although there was a tendency for tubercle bacilli to disappear earlier in the latter. Direct evidence has been presented that none of the dietary factors studied (calories, carbohydrates, total and animal proteins, fats, minerals and vitamins) appears to influence the attainment of quiescent disease among tuberculous patients treated for one year with an effective combination of antimicrobial drugs, and that initial chemotherapy of patients at home can be successful even if the dietary intake is low throughout the period of treatment

Comments on Kumar et al. (2023), Evidence of Strain Accumulation and Coupling Variation in the Himachal Region of NW Himalaya From Short Term Geodetic Measurements. Tectonics https://doi.org/10.1029/2022TC007690

Kumar et al. (2023) in their article discuss and highlight the complexities involved in the comparison of long-term and short-term ongoing deformation in the Northwest Himalaya and their influence over the topographic evolution of the region. Their observations that rely largely on the GNSS geodetic results (Kumar et al., 2023) have also been the basis of conclusions presented in a companion paper by Malik et al., 2023a. The conclusions presented in the latter-mentioned paper have been questioned in a rejoinder by Singh and Rajendran (2023) and defended by Malik et al. (2023b). Below we present pointwise inconsistencies in the present study (Kumar et al., 2023) and the conclusions presented therein. We present our differing observations of the two segments of the fault system called the ‘Khetpurali-Taksal’ Fault (KTF-1 and KTF-2), as discussed in the paper by Kumar et al. (2023

Intersubject Regularity in the Intrinsic Shape of Human V1

Previous studies have reported considerable intersubject variability in the three-dimensional geometry of the human primary visual cortex (V1). Here we demonstrate that much of this variability is due to extrinsic geometric features of the cortical folds, and that the intrinsic shape of V1 is similar across individuals. V1 was imaged in ten ex vivo human hemispheres using high-resolution (200 μm) structural magnetic resonance imaging at high field strength (7 T). Manual tracings of the stria of Gennari were used to construct a surface representation, which was computationally flattened into the plane with minimal metric distortion. The instrinsic shape of V1 was determined from the boundary of the planar representation of the stria. An ellipse provided a simple parametric shape model that was a good approximation to the boundary of flattened V1. The aspect ration of the best-fitting ellipse was found to be consistent across subject, with a mean of 1.85 and standard deviation of 0.12. Optimal rigid alignment of size-normalized V1 produced greater overlap than that achieved by previous studies using different registration methods. A shape analysis of published macaque data indicated that the intrinsic shape of macaque V1 is also stereotyped, and similar to the human V1 shape. Previoud measurements of the functional boundary of V1 in human and macaque are in close agreement with these results

Models and Strategies for Variants of the Job Shop Scheduling Problem

Recently, a variety of constraint programming and Boolean satisfiability approaches to scheduling problems have been introduced. They have in common the use of relatively simple propagation mechanisms and an adaptive way to focus on the most constrained part of the problem. In some cases, these methods compare favorably to more classical constraint programming methods relying on propagation algorithms for global unary or cumulative resource constraints and dedicated search heuristics. In particular, we described an approach that combines restarting, with a generic adaptive heuristic and solution guided branching on a simple model based on a decomposition of disjunctive constraints. In this paper, we introduce an adaptation of this technique for an important subclass of job shop scheduling problems (JSPs), where the objective function involves minimization of earliness/tardiness costs. We further show that our technique can be improved by adding domain specific information for one variant of the JSP (involving time lag constraints). In particular we introduce a dedicated greedy heuristic, and an improved model for the case where the maximal time lag is 0 (also referred to as no-wait JSPs).Comment: Principles and Practice of Constraint Programming - CP 2011, Perugia : Italy (2011

Beating dark-dark solitons in Bose-Einstein condensates

Motivated by recent experimental results, we study beating dark-dark solitons as a prototypical coherent structure that emerges in two-component Bose-Einstein condensates. We showcase their connection to dark- bright solitons via SO(2) rotation, and infer from it both their intrinsic beating frequency and their frequency of oscillation inside a parabolic trap. We identify them as exact periodic orbits in the Manakov limit of equal inter- and intra-species nonlinearity strengths with and without the trap and showcase the persistence of such states upon weak deviations from this limit. We also consider large deviations from the Manakov limit illustrating that this breathing state may be broken apart into dark-antidark soliton states. Finally, we consider the dynamics and interactions of two beating dark-dark solitons in the absence and in the presence of the trap, inferring their typically repulsive interaction.Comment: 13 pages, 14 figure