343 research outputs found
Passive Wireless SAW Sensors for IVHM
NASA aeronautical programs require integrated vehicle health monitoring (IVHM) to ensure the safety of the crew and the vehicles. Future IVHM sensors need to be small, light weight, inexpensive, and wireless. Surface acoustic wave (SAW) technology meets all of these constraints. In addition it operates in harsh environments and over wide temperature ranges, and it is inherently radiation hardened. This paper presents a survey of research opportunities for universities and industry to develop new sensors that address anticipated IVHM needs for aerospace vehicles. Potential applications of passive wireless SAW sensors from ground testing to high altitude aircraft operations are presented, along with some of the challenges and issues of the technology
A full quantal theory of one-neutron halo breakup reactions
We present a theory of one-neutron halo breakup reactions within the
framework of post-form distorted wave Born approximation wherein pure Coulomb,
pure nuclear and their interference terms are treated consistently in a single
setup. This formalism is used to study the breakup of one-neutron halo nucleus
11Be on several targets of different masses. We investigate the role played by
the pure Coulomb, pure nuclear and the Coulomb-nuclear interference terms by
calculating several reaction observables. The Coulomb-nuclear interference
terms are found to be important for more exclusive observables.Comment: 22 pages latex, 9 figures, submitted to Phy. Rev.
Many-body effects in 16O(e,e'p)
Effects of nucleon-nucleon correlations on exclusive reactions on
closed-shell nuclei leading to single-hole states are studied using
( MeV, ) as an example. The quasi-hole wave
function, calculated from the overlap of translationally invariant many-body
variational wave functions containing realistic spatial, spin and isospin
correlations, seems to describe the initial state of the struck proton
accurately inside the nucleus, however it is too large at the surface. The
effect of short-range correlations on the final state is found to be largely
cancelled by the increase in the transparency for the struck proton. It is
estimated that the values of the spectroscopic factors obtained with the DWIA
may increase by a few percent due to correlation effects in the final state.Comment: 21 Pages, PHY-7849-TH-9
New mechanism for the production of the extremely fast light particles in heavy-ion collisions in the Fermi energy domain
Employing a four-body classical model, various mechanisms responsible for the
production of fast light particles in heavy ion collisions at low and
intermediate energies have been studied. It has been shown that at energies
lower than 50 A MeV, light particles of velocities of more than two times
higher than the projectile velocities are produced due to the acceleration of
the target light-particles by the mean field of the incident nucleus. It has
also been shown that precision experimental reaction research in normal and
inverse kinematics is likely to provide vital information about which mechanism
is dominant in the production of fast light particles.Comment: 4 pages, 3 figures, LaTeX, to be published in Proceedings of VII
International School-Seminar on Heavy Ion Physics, May 27 - June 1, 2002,
Dubna, Russi
A Microscopic T-Violating Optical Potential: Implications for Neutron-Transmission Experiments
We derive a T-violating P-conserving optical potential for neutron-nucleus
scattering, starting from a uniquely determined two-body -exchange
interaction with the same symmetry. We then obtain limits on the T-violating
-nucleon coupling from neutron-transmission
experiments in Ho. The limits may soon compete with those from
measurements of atomic electric-dipole moments.Comment: 8 pages, 2 uuencoded figures in separate files (replaces version sent
earlier in the day with figures attached), in RevTeX 3, submitted to PR
Prospective assessment of CYP2D6 by genotyping, phenotyping and measurement of tamoxifen, PD 05-09 4-hydroxy-tamoxifen and endoxifen in breast cancer patients treated with tamoxifen.
Tamoxifen (tam) is a widely used endocrine therapy in the treatment of early and advanced stage breast cancer in women and men. It is a pro-drug having weak affinity with the estrogen receptor and needs to be converted to its main metabolite, endoxifen (endox), to have full anticancer activity.
Cytochrome 2D6 (CYP2D6) plays a major role in the metabolism of tamoxifen to endoxifen. It is genetically highly polymorphic and its activity influences profoundly the synthesis of endoxifen and potentially the efficacy of tamoxifen treatment.
Genotyping is currently the most widely used approach in studies and also in clinical practice to categorize patients as poor- (PM), intermediate- (IM), extensive- (EM) and ultra rapid-metabolizers (UM). Some clinicians already use genotyping in order to tailor the endocrine therapy of their patients.
Owing to the large inter-individual variations in concentrations of the active moitey due to genetic and non-genetic influences renders the predictive value of the test uncertain for an individual patient. A significant number of patients classified as EM or IM by genotyping have indeed relatively low endoxifen levels similar to PMs1. This suggests that genotyping is probably not the opti ma l meth o d f or predi cti ng end oxif en l evels
Calculations of three-body observables in ^8B breakup
We discuss calculations of three-body observables for the breakup of ^8B on a
^{58}Ni target at low energy using the coupled discretised continuum channels
approach. Calculations of both the angular distribution of the ^7Be fragments
and their energy distributions are compared with those measured at several
laboratory angles. In these observables there is interference between the
breakup amplitudes from different spin-parity excitations of the projectile.
The resulting angle and the energy distributions reveal the importance of the
higher-order continuum state couplings for an understanding of the
measurements.Comment: 22 pages (postscript), accepted in Phys. Rev.
Developing sustainability learning in business school curricula–productive boundary objects and participatory processes
© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. Sustainability learning is holistic and complex as it draws on diverse disciplines and can be interpreted differently within individual pedagogies. Embedding sustainability across and within business schools relies on developing suitable boundary objects. These may include representations such as models, frameworks or classificatory schemes that are malleable enough to be adapted for use within the disparate disciplines and pedagogies, yet durable enough to be recognisable and to maintain consistency across them. Boundary objects thus allow the sharing of ways of knowing or practice across various social boundaries. This paper outlines how participatory curriculum development processes can enable sustainability to be embedded in a business school curriculum. Distinct phases of the process were marked by different ways of knowing, as disciplinary-specific academics developed and embedded sustainability into and across curricula. Boundary objects were both outcomes and productive facilitators of this process. They acted as catalysts and attracted ongoing processes of dialogue, debate and meaning-making between these academics. The institutional context provided enabling conditions to legitimize outcomes from the participatory process. The process may be replicable in other business schools by the use of boundary objects
Sequential administration of temozolomide and fotemustine: Depletion of O6-alkyl guanine-DNA transferase in blood lymphocytes and in tumours
Background: The DNA repair protein O6-alkylguanine-DNA alkyl transferase (AT) mediates resistance to chloroethylnitro-soureas. Agents depleting AT such as DTIC and its new analogue temozolomide (TMZ) can reverse resistance to chloro-ethylnitrosoureas. We report the results of a dose finding study of TMZ in association with fotemustine. Patients and methods: Twenty-four patients with metastatic melanoma or recurrent glioma were treated with escalating dose of oral or intravenous TMZ ranging from 300 to 700 mg/m2, divided over two days. Fotemustine 100 mg/m2 was given intravenously on day 2, 4 hours after TMZ. AT depletion was measured in peripheral blood mononuclear cells (PBMCs) and in selected cases in melanoma metastases and was compared to TMZ pharmacokinetics. Results: The maximum tolerated dose (MTD) of TMZ was 400 mg/m2 (200 mg/m2/d) when associated with fotemustine the 2nd day with myelosuppression as dose limiting toxicity. The decrease of AT level in PBMCs was progressive and reached 34% of pretreatment values on day 2. There was however wide interindividual variability. AT reduction was neither dose nor route dependent and did not appear to be related to TMZ systemic exposure (AUC). In the same patients, AT depletion in tumour did not correlate with the decrease of AT observed in PBMCs. Conclusions: PBMCs may not be used as a surrogate of tumour for AT depletion. Further study should concentrate on the pharmacokinetic pharmacodynamic relationship in tumour to provide the basis for individually tailored therap
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