Cardiovascular Risk Factors and Dehydroepiandrosterone Sulfate Among Latinos in the Boston Puerto Rican Health Study.

Low blood dehydroepiandrosterone sulfate (DHEAS) levels have strong positive associations with stroke and coronary heart disease. However, it is unclear whether DHEAS is independently associated with cardiovascular risk factors. Therefore, we examined the association between cardiovascular risk factors and DHEAS concentration among a high-risk population of Latinos (Puerto Ricans aged 45 to 75 years at baseline) in a cross-sectional analysis of the Boston Puerto Rican Health Study. Of eligible participants, 72% completed baseline interviews and provided blood samples. Complete data were available for 1355 participants. Associations between cardiovascular risk factors (age, sex, total cholesterol, high-density lipid cholesterol, triglycerides, and glucose) and log-transformed DHEAS (μg/dL) were assessed. In robust multivariable regression analyses, DHEAS was significantly inversely associated with age (β = -12.4; 95% CI: -15.2, -9.7; per 5 years), being female (vs. male) (β = -46; 95% CI: -55.3, -36.6), and plasma triglyceride concentration (β = -0.2; 95% CI: -0.3, -0.1; per 10 mg/dL) and was positively associated with total cholesterol and plasma glucose levels (β = 1.8; 95% CI: 0.6, 3 and β = 0.2; 95% CI: 0.04, 0.3, respectively, per 10 mg/dL) after adjustment for smoking, alcohol, and physical activity and for postmenopausal hormone use in women. Estimates were unchanged after adjustment for measures of chronic disease and inflammation. Women exhibited a stronger age-related decline in DHEAS and a positive association with glucose in contrast to findings among men (P interaction < 0.05). In conclusion, in this large study of Latinos with a heavy cardiovascular risk factor burden, we observed significant associations between cardiovascular disease (CVD) risk factors and DHEAS, with variations by sex. These findings improve our understanding of the role DHEAS may play in CVD etiology

The Transition State in a Noisy Environment

Transition State Theory overestimates reaction rates in solution because conventional dividing surfaces between reagents and products are crossed many times by the same reactive trajectory. We describe a recipe for constructing a time-dependent dividing surface free of such recrossings in the presence of noise. The no-recrossing limit of Transition State Theory thus becomes generally available for the description of reactions in a fluctuating environment

Observational evidence for stochastic biasing

We show that the galaxy density in the Las Campanas Redshift Survey (LCRS) cannot be perfectly correlated with the underlying mass distribution since various galaxy subpopulations are not perfectly correlated with each other, even taking shot noise into account. This rules out the hypothesis of simple linear biasing, and suggests that the recently proposed stochastic biasing framework is necessary for modeling actual data.Comment: 4 pages, with 2 figures included. Minor revisions to match accepted ApJL version. Links and color fig at http://www.sns.ias.edu/~max/r_frames.html or from [email protected]

Physical Bias of Galaxies From Large-Scale Hydrodynamic Simulations

We analyze a new large-scale ($100h^{-1}$Mpc) numerical hydrodynamic simulation of the popular $\Lambda$CDM cosmological model, including in our treatment dark matter, gas and star-formation, on the basis of standard physical processes. The method, applied with a numerical resolution of $<200h^{-1}$kpc (which is still quite coarse for following individual galaxies, especially in dense regions), attempts to estimate where and when galaxies form. We then compare the smoothed galaxy distribution with the smoothed mass distribution to determine the "bias" defined as $b\equiv (\delta M/M)_{gal}/(\delta M/M)_{total}$ on scales large compared with the code numerical resolution (on the basis of resolution tests given in the appendix of this paper). We find that (holding all variables constant except the quoted one) bias increases with decreasing scale, with increasing galactic age or metallicity and with increasing redshift of observations. At the $8h^{-1}$Mpc fiducial comoving scale bias (for bright regions) is 1.35 at $z=0$ reaching to 3.6 at $z=3$, both numbers being consistent with extant observations. We also find that $(10-20)h^{-1}$Mpc voids in the distribution of luminous objects are as observed (i.e., observed voids are not an argument against CDM-like models) and finally that the younger systems should show a colder Hubble flow than do the early type galaxies (a testable proposition). Surprisingly, little evolution is found in the amplitude of the smoothed galaxy-galaxy correlation function (as a function of {\it comoving} separation). Testing this prediction vs observations will allow a comparison between this work and that of Kauffmann et al which is based on a different physical modelingmethod.Comment: in press, ApJ, 26 latex pages plus 7 fig

Research Progress Report: Fox-Pheasant Relationships in South Dakota, 1965

A 5-year cooperative study designed to obtain information regarding effects of foxes on pheasant populations in eastern South Dakota was initiated in 1964. Specific objectives were to determine (1) population fluctuations of foxes and pheasants, (2) fox food habits and reproductive characteristics and (3) effectiveness and cost of fox reduction to increase pheasant abundance. Studies were conducted on four pairs of 100-square-mile areas. Fox populations were reduced on one member of each pair beginning in January 1965, and individual foxes were removed on a complaint basis on the other. Each pair of areas is referred to as a unit. When summer pheasant data on the fox-reduction and check areas are considered, significant differences are noted in adult pheasants per mile, broods per mile, and brood size from 1964 to 1965. Changes in adult pheasants per mile in Unit 2 showed the decline in the fox-reduction area was significantly (0. 01) less than in the check area. However, in Units 1 and 4 the declines in the check areas were significantly (0. 01) less than those in the fox-reduction areas. The difference in decline in broods per mile in the fox-reduction compared to the check area from 1964 to 1965 was negligible in Unit 1. In Unit 2 the fox-reduction area showed a slight increase compared to a decrease in the check area. This difference is significant (0. 01). In Unit 4 a smaller decline occurred in the fox-reduction area than in the check area. The difference in Unit 4 is significant (0. 05). The proportion of hens with broods showed an increase from 1964 to 1965 in the fox-reduction areas of Units 1, 2, and 4 and a lesser increase or a decrease in the corresponding check areas. A significant (0. 01) increase in brood size occurred from 1964 to 1965 in the fox-reduction compared to the check area of Unit 1. A non-significant increase occurred in the check area compared to the fox-reduction area in Unit 2. The adult pheasant-per-mile averages during the spring of 1965 showed more birds in the fox-reduction area than in the check area of Unit 1, and the reverse in Unit 2. Neither difference is significant. Units 3 and 4 showed significantly (0. 01) more adults per mile in the fox reduction than in the check areas during this same period. Fox data revealed that counting tracks in snow along transects is the best of three methods for determining fox activity in an area. Such counts in reduction and check areas within each unit showed that fox activity was sufficiently comparable in each pair of areas prior to fox reduction. Methods used to reduce fox populations also reduced to some extent other predators, including nest robbers. Grasses, mice, pheasants, rabbits, and insects, in descending order, respectively, were the most frequently occurring items found in stomachs of foxes taken in the study areas from January to June 1965. Grasses were found in stomachs that also contained mice and insects. Pheasants were the item composing the greatest volume, followed by rabbits and mice. Prairie deer mice made up the majority of small mammal remains. (See more in Text

Can Alfalfa Be Hayed and Grazed

A study established at Cottonwood in 1981 is being evaluate to compare 10 grazing alfalfa varieties plus two hay types in three treatment combinations involving grazing and haying

Mammal population densities at a global scale are higher in human‐modified areas

Global landscapes are changing due to human activities with consequences for both biodiversity and ecosystems. For single species, terrestrial mammal population densities have shown mixed responses to human pressure, with both increasing and decreasing densities reported in the literature. How the impacts of human activities on mammal populations translates into altered global density patterns remains unclear. Here we aim to disentangle the effect of human impacts on large‐scale patterns of mammal population densities using a global dataset of 6729 population density estimates for 468 mammal species (representing 59% and 44% of mammalian orders and families). We fitted a mixed effect model to explain the variation in density based on a 1‐degree resolution as a function of the human footprint index (HFI), a global proxy of direct and indirect human disturbances, while accounting for body mass, trophic level and primary productivity (normalized vegetation index; NDVI). We found a significant positive relationship between population density and HFI, where population densities were higher in areas with a higher HFI (e.g. agricultural or suburban areas – no populations were located in very high HFI urban areas) compared to areas with a low HFI (e.g. wilderness areas). We also tested the effect of the individual components of the HFI and still found a consistent positive effect. The relationships remained positive even across populations of the same species, although variability among species was high. Our results indicate shifts in mammal population densities in human modified landscapes, which is due to the combined effect of species filtering, increased resources and a possible reduction in competition and predation. Our study provides further evidence that macroecological patterns are being altered by human activities, where some species will benefit from these activities, while others will be negatively impacted or even extirpated

Direct constraints on the dark matter self-interaction cross-section from the merging galaxy cluster 1E0657-56

We compare new maps of the hot gas, dark matter, and galaxies for 1E0657-56, a cluster with a rare, high-velocity merger occurring nearly in the plane of the sky. The X-ray observations reveal a bullet-like gas subcluster just exiting the collision site. A prominent bow shock gives an estimate of the subcluster velocity, 4500 km/s, which lies mostly in the plane of the sky. The optical image shows that the gas lags behind the subcluster galaxies. The weak-lensing mass map reveals a dark matter clump lying ahead of the collisional gas bullet, but coincident with the effectively collisionless galaxies. From these observations, one can directly estimate the cross-section of the dark matter self-interaction. That the dark matter is not fluid-like is seen directly in the X-ray -- lensing mass overlay; more quantitative limits can be derived from three simple independent arguments. The most sensitive constraint, sigma/m<1 cm^2/g, comes from the consistency of the subcluster mass-to-light ratio with the main cluster (and universal) value, which rules out a significant mass loss due to dark matter particle collisions. This limit excludes most of the 0.5-5 cm^2/g interval proposed to explain the flat mass profiles in galaxies. Our result is only an order-of-magnitude estimate which involves a number of simplifying, but always conservative, assumptions; stronger constraints may be derived using hydrodynamic simulations of this cluster.Comment: Text clarified; some numbers changed slightly for consistency with final version of the accompanying lensing paper. 6 pages, uses emulateapj. ApJ in pres