Virtual testing environment tools for railway vehicle certification

This paper describes the work performed in Work Package 6 of the European project DynoTRAIN. Its task was to investigate the effects that uncertainties present within the track and running conditions have on the simulated behaviour of a railway vehicle. Methodologies and frameworks for using virtual simulation and statistical tools, in order to reduce both the cost and time required for the certification of new or modified railway vehicles, were proposed. In particular, the project developed a virtual test track (VTT) toolkit that is capable of both generating a series of test tracks based on measurements, which can be used in vehicle virtual testing using computer simulation models, and also automatically handling the output results. The toolkit is compliant with prEN14363: 2013. The VTT was used as an experimental tool to analyse cross-correlations between track data (input) and matching vehicle response (output) based on data recorded using a test train. This paper discusses the issues encountered in the process and suggests avenues for future developments and potential use in the context of European cross-acceptance. The VTT offers benefits to the areas of design development and regulatory certification

Advanced subsonic transport propulsion

A brief review of the current NASA Energy Efficient Engine (E(3)) Project is presented. Included in this review are the factors that influenced the design of these turbofan engines and the advanced technology incorporated in them to reduce fuel consumption and improve environmental characteristics. In addition, factors such as the continuing spiral in fuel cost, that could influence future aircraft propulsion systems beyond those represented by the E(3) engines, are also discussed. Advanced technologies that will address these influencing factors and provide viable future propulsion systems are described. The potential importance of other propulsion system types, such as geared fans and turboshaft engines, is presented

Single-machine scheduling with stepwise tardiness costs and release times

We study a scheduling problem that belongs to the yard operations component of the railroad planning problems, namely the hump sequencing problem. The scheduling problem is characterized as a single-machine problem with stepwise tardiness cost objectives. This is a new scheduling criterion which is also relevant in the context of traditional machine scheduling problems. We produce complexity results that characterize some cases of the problem as pseudo-polynomially solvable. For the difficult-to-solve cases of the problem, we develop mathematical programming formulations, and propose heuristic algorithms. We test the formulations and heuristic algorithms on randomly generated single-machine scheduling problems and real-life datasets for the hump sequencing problem. Our experiments show promising results for both sets of problems

Optical Response of Grating-Coupler-Induced Intersubband Resonances: The Role of Wood's Anomalies

Grating-coupler-induced collective intersubband transitions in a quasi-two-dimensional electron system are investigated both experimentally and theoretically. Far-infrared transmission experiments are performed on samples containing a quasi-two-dimensional electron gas quantum-confined in a parabolic quantum well. For rectangular shaped grating couplers of different periods we observe a strong dependence of the transmission line shape and peak height on the period of the grating, i.e. on the wave vector transfer from the diffracted beams to the collective intersubband resonance. It is shown that the line shape transforms with increasing grating period from a Lorentzian into a strongly asymmetric line shape. Theoretically, we treat the problem by using the transfer-matrix method of local optics and apply the modal-expansion method to calculate the influence of the grating. The optically uniaxial quasi-two-dimensional electron gas is described in the long-wavelength limit of the random-phase approximation by a local dielectric tensor, which includes size quantization effects. Our theory reproduces excellently the experimental line shapes. The deformation of the transmission line shapes we explain by the occurrence of both types of Wood's anomalies.Comment: 28 pages, 7 figures. Physical Review B , in pres

The Use of Cafeteria Trials for the Selection of \u3ci\u3eDesmodium ovalifolium\u3c/i\u3e Genotypes

For the selection of tropical legumes which contain anti-nutritive components such as tannins, relative acceptability of genotypes to ruminants is of particular importance, since these plant components may influence selective grazing behaviour and subsequent animal productivity. Plant-animal interactions are not predictable from laboratory analyses. Involving grazing animals through the conduction of relative-acceptability (=cafeteria) trials at early stages of the germplasm selection process might therefore provide a convenient tool to adjust and confirm genotype selection based on laboratory quality analyses data. As part of a multilocational germplasm evaluation project, cafeteria-experiments were conducted at two contrasting environments in Colombia with a core collection of Desmodium ovalifolium, a tropical legume species containing tannins. The objective of these experiments was to assess the usefulness of such acceptability trials in the selection of D. ovalifolium genotypes. Relative acceptability indices for the 18 accessions confirm genotype selection based on a series of laboratory quality analyses during earlier stages of the project and indicate pronounced genotype-environment interactions. Moreover, animal activity profiles confirm the influence of plant-environment-animal interactions and thus the usefulness of cafeteriatrials for germplasm selection projects

The Active Nucleus of IC4970: A Nearby Example of Merger-Induced Cold-Gas Accretion

We present results from Chandra X-ray and Spitzer mid-infrared observations of the interacting galaxy pair NGC6872/IC4970 in the Pavo galaxy group and show that the smaller companion galaxy IC4970 hosts a highly obscured active galactic nucleus (AGN). The 0.5-10 keV X-ray luminosity of the nucleus is variable, increasing by a factor 2.9 to 1.7 x 10^{42} erg/s (bright state) on ~100 ks timescales. The X-ray spectrum of the is heavily absorbed (N_H = 3 x 10^{23} cm^{-2}) for power law models with Gamma = 1.5-2.0 and shows a clear 6.4 keV Fe Kalpha line with equivalent width of 144-195 eV. Limits on the diffuse emission in IC4970 from Chandra X-ray data suggest that the available power from Bondi accretion of hot interstellar gas may be an order of magnitude too small to power the AGN. Spitzer images show that 8 micron nonstellar emission is concentrated in the central 1 kpc of IC4970, consistent with high obscuration in this region. The mid-infrared colors of the nucleus are consistent with those expected for a highly obscured AGN. Taken together these data suggest that the nucleus of IC4970 is a Seyfert 2, triggered and fueled by cold material supplied to the central supermassive black hole as a result of the off-axis collision of IC4970 with the cold-gas rich spiral galaxy NGC6872.Comment: 10 pages, 9 figures, submitted to ApJ, MIR flux conversion error corrected in Table 4, MIR colors and paper text unchange

Stormy weather in 3C 196.1: nuclear outbursts and merger events shape the environment of the hybrid radio galaxy 3C 196.1

We present a multi-wavelength analysis based on archival radio, optical and X-ray data of the complex radio source 3C 196.1, whose host is the brightest cluster galaxy of a $z=0.198$ cluster. HST data show H$\alpha$+[N II] emission aligned with the jet 8.4 GHz radio emission. An H$\alpha$+[N II] filament coincides with the brightest X-ray emission, the northern hotspot. Analysis of the X-ray and radio images reveals cavities located at galactic- and cluster- scales. The galactic-scale cavity is almost devoid of 8.4 GHz radio emission and the south-western H$\alpha$+[N II] emission is bounded (in projection) by this cavity. The outer cavity is co-spatial with the peak of 147 MHz radio emission, and hence we interpret this depression in X-ray surface brightness as being caused by a buoyantly rising bubble originating from an AGN outburst $\sim$280 Myrs ago. A \textit{Chandra} snapshot observation allowed us to constrain the physical parameters of the cluster, which has a cool core with a low central temperature $\sim$2.8 keV, low central entropy index $\sim$13 keV cm$^2$ and a short cooling time of $\sim$500 Myr, which is $<0.05$ of the age of the Universe at this redshift. By fitting jumps in the X-ray density we found Mach numbers between 1.4 and 1.6, consistent with a shock origin. We also found compelling evidence of a past merger, indicated by a morphology reminiscent of gas sloshing in the X-ray residual image. Finally, we computed the pressures, enthalpies $E_{cav}$ and jet powers $P_{jet}$ associated with the cavities: $E_{cav}\sim7\times10^{58}$ erg, $P_{jet}\sim1.9\times10^{44}$ erg s$^{-1}$ for the inner cavity and $E_{cav}\sim3\times10^{60}$ erg, $P_{jet}\sim3.4\times10^{44}$ erg s$^{-1}$ for the outer cavity.Comment: 14 pages, 4 figures, ApJ accepte

MEPicides: Potent antimalarial prodrugs targeting isoprenoid biosynthesis

AbstractThe emergence of Plasmodium falciparum resistant to frontline therapeutics has prompted efforts to identify and validate agents with novel mechanisms of action. MEPicides represent a new class of antimalarials that inhibit enzymes of the methylerythritol phosphate (MEP) pathway of isoprenoid biosynthesis, including the clinically validated target, deoxyxylulose phosphate reductoisomerase (Dxr). Here we describe RCB-185, a lipophilic prodrug with nanomolar activity against asexual parasites. Growth of P. falciparum treated with RCB-185 was rescued by isoprenoid precursor supplementation, and treatment substantially reduced metabolite levels downstream of the Dxr enzyme. In addition, parasites that produced higher levels of the Dxr substrate were resistant to RCB-185. Notably, environmental isolates resistant to current therapies remained sensitive to RCB-185, the compound effectively treated sexually-committed parasites, and was both safe and efficacious in malaria-infected mice. Collectively, our data demonstrate that RCB-185 potently and selectively inhibits Dxr in P. falciparum, and represents a promising lead compound for further drug development.</jats:p