56 research outputs found
Predictive biomarkers for response to EGFR-directed monoclonal antibodies for advanced squamous cell lung cancer
Writing assistance was funded by Eli Lilly and Company (no grant numbers apply).Peer reviewedPublisher PD
Paternal effects on early embryogenesis
Historically, less attention has been paid to paternal effects on early embryogenesis than maternal effects. However, it is now apparent that certain male factor infertility phenotypes are associated with increased DNA fragmentation and/or chromosome aneuploidies that may compromise early embryonic development. In addition, there is a growing body of evidence that the fertilizing sperm has more function than just carrying an intact, haploid genome. The paternally inherited centrosome is essential for normal fertilization, and the success of higher order chromatin packaging may impact embryogenesis. Epigenetic modifications of sperm chromatin may contribute to the reprogramming of the genome, and sperm delivered mRNA has also been hythesized to be necessary for embryogenesis. There is less information about the epigenetic factors affecting embryogenesis than genetic factors, but the epigenetics of gamete and early embryogenesis is a rapidly advancing field
Gemcitabine (G) /carboplatin (C) surveillance study in patients with advanced or metastatic non-small cell lung cancer (NSCLC): Survival update of a phase II study of a 21 versus 28-day schedule
Gemcitabine (G) /carboplatin (C) surveillance study in patients with advanced or metastatic non-small cell lung cancer (NSCLC): Survival update of a phase II study of a 21 versus 28-day schedule
Effect of race on the safety and efficacy outcomes of gemcitabine plus paclitaxel treated patients with metastatic breast cancer (MBC): Analyses from a phase III trial
Comparison of pemetrexed plus cisplatin with other first-line doublets in advanced non-small cell lung cancer (NSCLC): A combined analysis of three phase III trials.
Randomized phase II trial of pemetrexed with either cisplatin or carboplatin in extensive stage small cell lung cancer
Randomized phase II trial of pemetrexed with either cisplatin or carboplatin in extensive stage small cell lung cancer
Predictive value of RRM1 and ERCC1 protein levels in a prospective community-based trial of gemcitabine/carboplatin (GC) vs gemcitabine (G) alone
Final report of a phase I clinical study of biweekly pemetrexed and gemcitabine in patients with advanced solid tumors: Second dosing schedule & response
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