6,876 research outputs found
The Complexity of Vector Spin Glasses
We study the annealed complexity of the m-vector spin glasses in the
Sherrington-Kirkpatrick limit. The eigenvalue spectrum of the Hessian matrix of
the Thouless-Anderson-Palmer (TAP) free energy is found to consist of a
continuous band of positive eigenvalues in addition to an isolated eigenvalue
and (m-1) null eigenvalues due to rotational invariance. Rather surprisingly,
the band does not extend to zero at any finite temperature. The isolated
eigenvalue becomes zero in the thermodynamic limit, as in the Ising case (m=1),
indicating that the same supersymmetry breaking recently found in Ising spin
glasses occurs in vector spin glasses.Comment: 4 pages, 2 figure
Roscoe Reid Graham (1890 to 1948): a Canadian pioneer in general surgery.
Roscoe Reid Graham, a Canadian surgeon trained at the University of Toronto, was a true pioneer in the field of general surgery. Although he may be best known for his omental patch repair of perforated duodenal ulcers-often referred to as the Graham patch -he had a number of other significant accomplishments that decorated his surgical career. Dr. Graham is credited with being the first surgeon to successfully enucleate an insulinoma. He ventured to do an essentially brand new operation based solely on his patient\u27s symptoms and physical findings, a courageous move that even some of the most talented surgeons would shy away from. He also spent a large portion of his career dedicated to the study of rectal prolapse, working tirelessly to rid his patients of this awful affliction. He was recognized by a number of different surgical associations for his operative successes and was awarded membership to those both in Canada and the United States. Despite all of these accolades, Dr. Graham remained grounded and always fervent in his dedication to the patient and their presenting symptom(s), reminding us that to do anything more would be meddlesome. In an age when medical professionals are often all too eager to make unnecessary interventions, it is imperative that we look back at our predecessors such as Roscoe Reid Graham, for they will continually redirect us toward our one and only obligation: the patient
James Mann, M.D. (1759-1832): Military Surgeon for the Second War of Independence .
The War of 1812 is remembered for the Burning of Washington, and Francis Scott Key’s “The Star Spangled Banner,” but little else. It was a poorly funded war of relatively short duration and nebulous resolution. Under such circumstances, it is understandable that the “Second War of Independence” failed to produce many notable military or medical advancements. However, one surgeon took it upon himself to recount his experiences in the field. For his dedication to the art and science of medicine, James Mann deserves recognition
First-Order Transition and Critical End-Point in Vortex Liquids in Layered Superconductors
We calculate various thermodynamic quantities of vortex liquids in a layered
superconductor by using the nonperturbative parquet approximation method, which
was previously used to study the effect of thermal fluctuations in
two-dimensional vortex systems. We find there is a first-order transition
between two vortex liquid phases which differ in the magnitude of their
correlation lengths. As the coupling between the layers increases,the
first-order transition line ends at a critical point. We discuss the possible
relation between this critical end-point and the disappearance of the
first-order transition which is observed in experiments on high temperature
superconductors at low magnetic fields.Comment: 9 pages, 5 figure
Low-energy molecular collisions in a permanent magnetic trap
Cold, neutral hydroxyl radicals are Stark decelerated and confined within a
magnetic trap consisting of two permanent ring magnets. The OH molecules are
trapped in the ro-vibrational ground state at a density of
cm and temperature of 70 mK. Collisions between the trapped OH sample
and supersonic beams of atomic He and molecular D are observed and
absolute collision cross sections measured. The He--OH and D--OH
center-of-mass collision energies are tuned from 60 cm to 230 cm
and 145 cm to 510 cm, respectively, yielding evidence of reduced
He--OH inelastic cross sections at energies below 84 cm, the OH ground
rotational level spacing.Comment: 4 pages, 4 figure
A Sub-Type of Familial Pancreatic Cancer: Evidence and Implications of Loss-of-Function Polymorphisms in Indoleamine-2,3-Dioxygenase-2.
BACKGROUND: Variation in an individual\u27s genetic status can impact the development of pancreatic ductal adenocarcinoma; however, the majority of familial pancreatic cancers (FPC) cannot yet be attributed to a specific inherited mutation. We present data suggesting a correlation between loss-of-function single nucleotide polymorphisms (SNPs) in an immune regulator gene, indoleamine-2,3-dioxygenase-2 (IDO2), and an increased risk of FPC.
STUDY DESIGN: Germline DNA from patients who underwent resection for pancreatic ductal adenocarcinoma (n = 79) was sequenced for the IDO2 SNPs R248W and Y359Stop. Genotypes resulting in inactivation of IDO2 (Y325X homozygous, R248W homozygous) were labeled as homozygous, and the other genotypes were grouped as wild-type or heterozygous. Genotype distributions of each SNP were analyzed for Hardy-Weinberg deviation. A genotype frequency set from the 1000 Genomes Project (n = 99) was used as a genetic control for genotype distribution comparisons.
RESULTS: A significant 2-fold increase in the overall prevalence of the Y359Stop homozygous genotype compared with the expected Hardy-Weinberg equilibrium was noted (p \u3c 0.05). Familial pancreatic cancer was noted in 15 cases (19%) and comparison of the FPC cohort set to the genetic control set showed a 3-fold increase in Y359Stop homozygous rates (p = 0.054). Overall in our cohort, the homozygous genotype group was associated with increased risk of FPC (odds ratio 5.4; 95% CI 1.6 to 17.6; p \u3c 0.01). Sex, age at diagnosis, and history of tobacco use were not found to be significantly associated with FPC.
CONCLUSIONS: Our preliminary data suggest a strong association between the IDO2 inactivating Y359Stop SNP and an increased risk of FPC when compared with the control group. Future studies will evaluate the value of IDO2 genotyping as a prognostic, early detection marker for pancreatic ductal adenocarcinoma and a predictive marker for novel immune checkpoint therapies
Francis F. Maury, M.D. (1840 to 1879): an often forgotten pioneer in early American surgery.
Francis F. Maury (Fig. 1) was born on August 9, 1840, in Danville, Kentucky, where he was raised on a farm by his mother and father. His father was an Episcopal clergyman of Huguenot descent, whose forefathers had fled from France to escape religious persecution. After receiving a Bachelor of Arts degree from Center College in the summer of 1860, he entered medical school at the University of Virginia. After one full term, he matriculated to Philadelphia’s Jefferson Medical College and completed his medical education as a private student under the direction of Dr. Samuel D. Gross.1, 2 He obtained his Doctorate of Medicine in March of 1862 at the age of only 21 years. Such were his talents as a medical student that he was appointed resident physician at the Philadelphia Hospital one month before his graduation. Although he spent only one year there, he developed a reputation as a tireless, devoted, and charming surgeon. In April 1863, Maury was assigned to duty at the South Street General Hospital to serve as acting assistant surgeon in the U.S. Army for two years. In October 1863, he was appointed assistant professor to Dr. Gross and six months later became chief of Dr. Gross’ surgical clinic at Jefferson Medical College. In November 1865, at the age of only 25 years, he returned to the Philadelphia Hospital, where he was appointed one of the chief surgeons on the retirement of Dr. Gross from that institution. In April of 1866, Maury founded the Summer Course on Venereal and Cutaneous Diseases in the Jefferson Medical College, where he taught until his death.1 Although Maury did not consider himself a dermatologist, his expertise in this emerging field was widely recognized
Reconstruction of spectral solar irradiance since 1700 from simulated magnetograms
We present a reconstruction of the spectral solar irradiance since 1700 using
the SATIRE-T2 (Spectral And Total Irradiance REconstructions for the Telescope
era version 2) model. This model uses as input magnetograms simulated with a
surface flux transport model fed with semi-synthetic records of emerging
sunspot groups. We used statistical relationships between the properties of
sunspot group emergence, such as the latitude, area, and tilt angle, and the
sunspot cycle strength and phase to produce semi-synthetic sunspot group
records starting in the year 1700. The semisynthetic records are fed into a
surface flux transport model to obtain daily simulated magnetograms that map
the distribution of the magnetic flux in active regions (sunspots and faculae)
and their decay products on the solar surface. The magnetic flux emerging in
ephemeral regions is accounted for separately based on the concept of extended
cycles whose length and amplitude are linked to those of the sunspot cycles
through the sunspot number. The magnetic flux in each surface component
(sunspots, faculae and network, and ephemeral regions) was used to compute the
spectral and total solar irradiance between the years 1700 and 2009. This
reconstruction is aimed at timescales of months or longer although the model
returns daily values. We found that SATIRE-T2, besides reproducing other
relevant observations such as the total magnetic flux, reconstructs the total
solar irradiance (TSI) on timescales of months or longer in good agreement with
the PMOD composite of observations, as well as with the reconstruction starting
in 1878 based on the RGO-SOON data. The model predicts an increase in the TSI
of 1.2[+0.2, -0.3] Wm-2 between 1700 and the present. The spectral irradiance
reconstruction is in good agreement with the UARS/SUSIM measurements as well as
the Lyman-alpha composite.Comment: 13 pages, 10 figure
Pattern formation of indirect excitons in coupled quantum wells
Using a nonlinear Schr\"odinger equation including short-range two-body
attraction and three-body repulsion, we investigate the spatial distribution of
indirect excitons in semiconductor coupled quantum wells. The results obtained
can interpret the experimental phenomenon that annular exciton cloud first
contracts then expands when the number of confined excitons is increased in
impurity potential well, as observed by Lai \emph{et al.} [Lai ,
Science \textbf{303}, 503 (2004)]. In particular, the model reconciles the
patterns of exciton rings reported by Butov \emph{et al.} [Butov ,
Nature \textbf{418}, 751 (2002)]. At higher densities, the model predicts much
richer patterns, which could be tested by future experiments.Comment: 5 Revtex4 pages, 3 figure
UV solar irradiance in observations and the NRLSSI and SATIRE-S models
Total solar irradiance and UV spectral solar irradiance have been monitored
since 1978 through a succession of space missions. This is accompanied by the
development of models aimed at replicating solar irradiance by relating the
variability to solar magnetic activity. The NRLSSI and SATIRE-S models provide
the most comprehensive reconstructions of total and spectral solar irradiance
over the period of satellite observation currently available. There is
persistent controversy between the various measurements and models in terms of
the wavelength dependence of the variation over the solar cycle, with
repercussions on our understanding of the influence of UV solar irradiance
variability on the stratosphere. We review the measurement and modelling of UV
solar irradiance variability over the period of satellite observation. The
SATIRE-S reconstruction is consistent with spectral solar irradiance
observations where they are reliable. It is also supported by an independent,
empirical reconstruction of UV spectral solar irradiance based on UARS/SUSIM
measurements from an earlier study. The weaker solar cycle variability produced
by NRLSSI between 300 and 400 nm is not evident in any available record. We
show that although the method employed to construct NRLSSI is principally
sound, reconstructed solar cycle variability is detrimentally affected by the
uncertainty in the SSI observations it draws upon in the derivation. Based on
our findings, we recommend, when choosing between the two models, the use of
SATIRE-S for climate studies
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