Disciplined doctors: Does the sex of a doctor matter? A cross-sectional study examining the association between a doctor's sex and receiving sanctions against their medical registration.

To examine the association between doctors' sex and receiving sanctions on their medical registration, while controlling for other potentially confounding variables

Detection of cold pain, cold allodynia and cold hyperalgesia in freely behaving rats

BACKGROUND: Pain is elicited by cold, and a major feature of many neuropathic pain states is that normally innocuous cool stimuli begin to produce pain (cold allodynia). To expand our understanding of cold induced pain states we have studied cold pain behaviors over a range of temperatures in several animal models of chronic pain. RESULTS: We demonstrate that a Peltier-cooled cold plate with ± 1°C sensitivity enables quantitative measurement of a detection withdrawal response to cold stimuli in unrestrained rats. In naïve rats the threshold for eliciting cold pain behavior is 5°C. The withdrawal threshold for cold allodynia is 15°C in both the spared nerve injury and spinal nerve ligation models of neuropathic pain. Cold hyperalgesia is present in the spared nerve injury model animals, manifesting as a reduced latency of withdrawal response threshold at temperatures that elicit cold pain in naïve rats. We also show that following the peripheral inflammation produced by intraplantar injection of complete Freund's adjuvant, a hypersensitivity to cold occurs. CONCLUSION: The peltier-cooled provides an effective means of assaying cold sensitivity in unrestrained rats. Behavioral testing of cold allodynia, hyperalgesia and pain will greatly facilitate the study of the neurobiological mechanisms involved in cold/cool sensations and enable measurement of the efficacy of pharmacological treatments to reduce these symptoms

poolMC: Smart pooling of mRNA samples in microarray experiments

Background: Typically, pooling of mRNA samples in microarray experiments implies mixing mRNA from several biological-replicate samples before hybridization onto a microarray chip. Here we describe an alternative smart pooling strategy in which different samples, not necessarily biological replicates, are pooled in an information theoretic efficient way. Further, each sample is tested on multiple chips, but always in pools made up of different samples. The end goal is to exploit the compressibility of microarray data to reduce the number of chips used and increase the robustness to noise in measurements. Results: A theoretical framework to perform smart pooling of mRNA samples in microarray experiments was established and the software implementation of the pooling and decoding algorithms was developed in MATLAB. A proof-of-concept smart pooled experiment was performed using validated biological samples on commercially available gene chips. Conclusions: The theoretical developments and experimental demonstration in this paper provide a useful starting point to investigate smart pooling of mRNA samples in microarray experiments. Important conditions for its successful implementation include linearity of measurements, sparsity in data, and large experiment size.

Sex differences in medico-legal action against doctors: a systematic review and meta-analysis

The relationship between male sex and poor performance in doctors remains unclear, with high profile studies showing conflicting results. Nevertheless, it is an important first step towards understanding the causes of poor performance in doctors. This article aims to establish the robustness of the association between male sex and poor performance in doctors, internationally and over time

Therapy for Auditory Processing Impairment in Aphasia: An evaluation of two approaches

Purpose: This study evaluated two forms of discrimination therapy for auditory processing impairment in aphasia. It aimed to determine whether therapy can improve speech perception and/or help participants use semantic information to compensate for their impairment. Changes in listening were also explored by recording the level of facilitation needed during therapy tasks. Finally the study examined the effect of therapy on an everyday listening activity: a telephone message task. Method: The study employed a repeated measures design. Eight participants received 12 sessions each of phonological and semantic-phonological therapy. Both programmes used minimal pair judgement tasks, but the latter embedded such tasks within a meaningful context, so encouraged the strategic use of semantic information (semantic bootstrapping). Experimental measures of auditory discrimination and comprehension were administered twice before therapy, once after each programme, and again six weeks later. The telephone message task was also administered at each time point. Test data were subjected to both group and individual analyses. Records of progress during therapy (i.e changes in support needed to carry out therapy tasks) were completed during treatment and analysed across the group. Results: Group analyses showed no significant changes in tests of word and nonword discrimination as a result of therapy. One comprehension task improved following therapy, but two did not. There was also no indication that therapy improved the discrimination of treated words, as assessed by a priming task. The facilitation scores indicated that participants needed less support during tasks as therapy progressed, possibly as a result of improved listening. There was a significant effect of time on the telephone message task. Across all tasks there were few individual gains. Conclusions: The results offer little evidence that therapy improved participants’ discrimination or semantic bootstrapping skills. Some changes in listening may have occurred, as indicated by the facilitation scores. Reasons for the null findings are discussed

Production and evaporation of higher dimensional black holes

This thesis is a study of the theory and phenomenology of trans-Planckian black holes, in TeV gravity extra-dimensional theories. The introduction starts with the motivation for this beyond the Standard Model scenario (chapter 1), a summary of the theoretical tools to formulate the theory, and a summary of the best bounds from experiment (chapter 2). In chapter 3, after setting up some notation and describing well known solutions in 4 + n-dimensional general relativity, we construct an approximate effective background for a brane charged rotating higher-dimensional black hole. This is achieved by solving Maxwell’s equations perturbatively on the brane to obtain the electromagnetic field. A brief study of the effect of rotation on the absorption of classical particles is also provided. Chapter 4 is a review of methods to model black hole production focusing on the trapped surface method. A model for the mass and angular momentum loss into gravitational radiation is described. A detailed study of the effects of particle mass and charge, for fermions and scalars on the effective brane charged background, is presented in chapters 5 and 6. After coupling the fields to the background, the separated radial wave equations for both perturbations are obtained (chapter 5) and they are integrated using a detailed numerical method as well as analytic approximations (chapter 6). Similarly, a method is described to obtain high accuracy angular functions based on series expansions. We conclude the theoretical study by evaluating the Hawking spectra for various combinations of spin, mass, charge and rotation parameters, and discuss them comparatively. The last part of the thesis is on the implementation of the theoretical results in the new CHARYBDIS2 Monte Carlo simulation of black hole production and decay (chapter 7), and on the analysis of the phenomenological consequences (chapter 8). The main new features implemented in CHARYBDIS2 are: a full treatment of the spin-down phase using the angular and energy distributions of the associated Hawking radiation; an improved model for energy and angular momentum loss in the production process, and a wider range of options for the Planck-scale termination of the decay. The main conclusions of this thesis and an outlook on future directions are summarised in the final chapter.This work was funded by Fundação para a Ciência e Tecnologia (FCT) - Portugal grant SFRH/BD/23052/2005 co-financed by POPH/FSE

The MultiSite Spectroscopic Telescope campaign: 2m spectroscopy of the V361 Hya variable PG1605+072

We present results and analysis for the 2m spectroscopic part of the MultiSite Spectroscopic Telescope (MSST) campaign undertaken in May/June 2002. The goal of the project was to observe the pulsating subdwarf B star PG1605+072 simultaneously in velocity and photometry and to resolve as many of the >50 known modes as possible, which will allow a detailed asteroseismological analysis. We have obtained over 150 hours of spectroscopy, leading to an unprecedented noise level of only 207m/s. We report here the detection of 20 frequencies in velocity, with two more likely just below our detection threshold. In particular, we detect 6 linear combinations, making PG1605+072 only the second star known to show such frequencies in velocity. We investigate the phases of these combinations and their parent modes and find relationships between them that cannot be easily understood based on current theory. These observations, when combined with our simultaneous photometry, should allow asteroseismology of this most complicated of sdB pulsators.Comment: 9 pages, 5 figures, accepted for publication in A&A; Figure 1 at lower resolution than accepted versio

A Child with Chronic Manganese Exposure from Drinking Water

The patient's family bought a home in a suburb, but the proximity of the house to wetlands and its distance from the town water main prohibited connecting the house to town water. The family had a well drilled and they drank the well water for 5 years, despite the fact that the water was turbid, had a metallic taste, and left an orange-brown residue on clothes, dishes, and appliances. When the water was tested after 5 years of residential use, the manganese concentration was elevated (1.21 ppm; U.S. Environmental Protection Agency reference, < 0.05 ppm). The family's 10-year-old son had elevated manganese concentrations in whole blood, urine, and hair. The blood manganese level of his brother was normal, but his hair manganese level was elevated. The patient, the 10-year-old, was in the fifth grade and had no history of learning problems; however, teachers had noticed his inattentiveness and lack of focus in the classroom. Our results of cognitive testing were normal, but tests of memory revealed a markedly below-average performance: the patient's general memory index was at the 13th percentile, his verbal memory at the 19th percentile, his visual memory at the 14th percentile, and his learning index at the 19th percentile. The patient's free recall and cued recall tests were all 0.5-1.5 standard deviations (1 SD = 16th percentile) below normal. Psychometric testing scores showed normal IQ but unexpectedly poor verbal and visual memory. These findings are consistent with the known toxic effects of manganese, although a causal relationship cannot necessarily be inferred

The Rise and Fall of Debris Disks: MIPS Observations of h and chi Persei and the Evolution of Mid-IR Emission from Planet Formation

We describe Spitzer/MIPS observations of the double cluster, h and $\chi$ Persei, covering a $\sim$ 0.6 square-degree area surrounding the cores of both clusters. The data are combined with IRAC and 2MASS data to investigate $\sim$ 616 sources from 1.25-24 $\mu m$. We use the long-baseline $K_{s}$-[24] color to identify two populations with IR excess indicative of circumstellar material: Be stars with 24 $\mu m$ excess from optically-thin free free emission and 17 fainter sources (J$\sim$ 14-15) with [24] excess consistent with a circumstellar disk. The frequency of IR excess for the fainter sources increases from 4.5 $\mu m$ through 24 $\mu m$. The IR excess is likely due to debris from the planet formation process. The wavelength-dependent behavior is consistent with an inside-out clearing of circumstellar disks. A comparison of the 24 $\mu m$ excess population in h and $\chi$ Per sources with results for other clusters shows that 24 $\mu m$ emission from debris disks 'rises' from 5 to 10 Myr, peaks at $\sim$ 10-15 Myr, and then 'falls' from $\sim$ 15/20 Myr to 1 Gyr.Comment: 48 pages, 15 figures, accepted for publication in The Astrophysical Journa