Mental health clients confirm the value of occupation in building competence and self-identity

Engagement in occupation is proposed to enhance health and wellbeing. To date, few studies have demonstrated this in relation to people with mental health problems. This study aimed to evaluate occupational therapy’s beliefs in the restorative powers of occupation from the perspective of people with enduring mental health problems living in the community. Qualitative research methods were used in two mental health day service settings: a workshop, where woodwork was provided as a medium for creative therapy, and a drop-in facility. Participant observation was undertaken over 10 sessions and, during six in-depth interviews, the clients were asked about their occupational experiences and whether they had perceived any benefits from engagement in occupation. Content and inductive analysis as well as concept mapping of the data resulted in emergent themes and subthemes. Occupation was identified both as a means for building competence through the acquisition of skills, coping with challenges and achieving success and as a medium for developing self-identity through the drive to create, feelings of usefulness and engendering a sense of self. These themes help to support the need for an increase in the provision of meaningful occupation for people with enduring mental health problems. However, further research is required to develop and corroborate the findings

Investigation of single crystal ferrite thin film Semiannual report, 1 Feb. - 31 Jul. 1969

Vapor deposition of single crystal thin films of lithium ferrite utilizing ferric chlorid

Investigation of single-crystal ferrite thin film

Chemical vapor deposition growth of epitaxial single crystal lithium ferrite thin film

Regulation of neuronal excitability through pumilio-dependent control of a sodium channel gene

Dynamic changes in synaptic connectivity and strength, which occur during both embryonic development and learning, have the tendency to destabilize neural circuits. To overcome this, neurons have developed a diversity of homeostatic mechanisms to maintain firing within physiologically defined limits. In this study, we show that activity-dependent control of mRNA for a specific voltage-gated Na+ channel [encoded by paralytic (para)] contributes to the regulation of membrane excitability in Drosophila motoneurons. Quantification of para mRNA, by real-time reverse-transcription PCR, shows that levels are significantly decreased in CNSs in which synaptic excitation is elevated, whereas, conversely, they are significantly increased when synaptic vesicle release is blocked. Quantification of mRNA encoding the translational repressor pumilio (pum) reveals a reciprocal regulation to that seen for para. Pumilio is sufficient to influence para mRNA. Thus, para mRNA is significantly elevated in a loss-of-function allele of pum (pumbemused), whereas expression of a full-length pum transgene is sufficient to reduce para mRNA. In the absence of pum, increased synaptic excitation fails to reduce para mRNA, showing that Pum is also necessary for activity-dependent regulation of para mRNA. Analysis of voltage-gated Na+ current (INa) mediated by para in two identified motoneurons (termed aCC and RP2) reveals that removal of pum is sufficient to increase one of two separable INa components (persistent INa), whereas overexpression of a pum transgene is sufficient to suppress both components (transient and persistent). We show, through use of anemone toxin (ATX II), that alteration in persistent INa is sufficient to regulate membrane excitability in these two motoneurons

Information retrieval system

Generalized information storage and retrieval system capable of generating and maintaining a file, gathering statistics, sorting output, and generating final reports for output is reviewed. File generation and file maintenance programs written for the system are general purpose routines

Investigation of single crystal ferrite thin films

Materials suitable for use in magnetic bubble domain memories were developed for aerospace applications. Practical techniques for the preparation of such materials in forms required for fabrication of computer memory devices were considered. The materials studied were epitaxial films of various compositions of the gallium-substituted yttrium gadolinium iron garnet system. The major emphasis was to determine their bubble properties and the conditions necessary for growing uncracked, high quality films

Can the thermal instability drive turbulence?

The thermal instability with a piecewise power law cooling function is investigated using one- and three-dimensional simulations with periodic and shearing-periodic boundary conditions in the presence of constant thermal diffusion and kinematic viscosity coefficients. Consistent with earlier findings, the flow behavior depends on the average density, . When $\bra{\rho}$ is in the range 1-5 x 10^{-24} g cm^{-3} the system is unstable and segregates into cool and warm phases with temperatures of roughly 100 and 10^4 K, respectively. However, in all cases the resulting average pressure is independent of and just a little above the minimum value. For a constant heating rate of 0.015 erg g^{-1} s^{-1}, the mean pressure is around 24 x 10^{-14} dyn (corresponding to p/k_B ~ K cm^{-3}). Cool patches tend to coalesce into bigger ones. In all cases investigated there is no sustained turbulence, which is in agreement with earlier results. Simulations in which turbulence is driven by a body force show that when rms velocities of between 10 and 30 km/s are obtained, the resulting dissipation rates rates are comparable to the thermal energy input rate. The resulting mean pressures are then about 30 x 10^{-14} dyn, corresponding to p/k_B ~ 2170 K cm^{-3}. This is comparable to the value expected for the Galaxy. Differential rotation tends to make the flow two-dimensional, that is, uniform in the streamwise direction, but this does not lead to instability.Comment: 10 pages, 13 figure

Strong interaction of a turbulent spot with a shock-induced separation bubble

Direct numerical simulations have been conducted to study the passage of a turbulent spot through a shock-induced separation bubble. Localized blowing is used to trip the boundary layer well upstream of the shock impingement, leading to mature turbulent spots at impingement, with a length comparable to the length of the separation zone. Interactions are simulated at free stream Mach numbers of two and four, for isothermal (hot) wall boundary conditions. The core of the spot is seen to tunnel through the separation bubble, leading to a transient reattachment of the flow. Recovery times are long due to the influence of the calmed region behind the spot. The propagation speed of the trailing interface of the spot decreases during the interaction and a substantial increase in the lateral spreading of the spot was observed. A conceptual model based on the growth of the lateral shear layer near the wingtips of the spot is used to explain the change in lateral growth rat

Polarization restricts hepatitis C virus entry into HepG2 hepatoma cells

The primary reservoir for hepatitis C virus (HCV) replication is believed to be hepatocytes, which are highly polarized with tight junctions (TJ) separating their basolateral and apical domains. HepG2 cells develop polarity over time, resulting in the formation and remodeling of bile canalicular (BC) structures. HepG2 cells expressing CD81 provide a model system to study the effects of hepatic polarity on HCV infection. We found an inverse association between HepG2-CD81 polarization and HCV pseudoparticle entry. As HepG2 cells polarize, discrete pools of claudin-1 (CLDN1) at the TJ and basal/lateral membranes develop, consistent with the pattern of receptor staining observed in liver tissue. The TJ and nonjunctional pools of CLDN1 show an altered association with CD81 and localization in response to the PKA antagonist Rp-8-Br-cyclic AMPs (cAMPs). Rp-8-Br-cAMPs reduced CLDN1 expression at the basal membrane and inhibited HCV infection, supporting a model where the nonjunctional pools of CLDN1 have a role in HCV entry. Treatment of HepG2 cells with proinflammatory cytokines, tumor necrosis factor alpha and gamma interferon, perturbed TJ integrity but had minimal effect(s) on cellular polarity and HCV infection, suggesting that TJ integrity does not limit HCV entry into polarized HepG2 cells. In contrast, activation of PKC with phorbol ester reduced TJ integrity, ablated HepG2 polarity, and stimulated HCV entry. Overall, these data show that complex hepatocyte-like polarity alters CLDN1 localization and limits HCV entry, suggesting that agents which disrupt hepatocyte polarity may promote HCV infection and transmission within the liver

Mapping giant magnetic fields around dense solid plasmas by high resolution magneto-optical microscopy

We investigate distribution of magnetic fields around dense solid plasmas generated by intense p-polarized laser (~10^{16} W.cm^{-2}, 100 fs) irradiation of magnetic tapes, using high sensitivity magneto optical microscopy. We present evidence for giant axial magnetic fields and map out for the first time the spatial distribution of these fields. By using the axial magnetic field distribution as a diagnostic tool we uncover evidence for angular momentum associated with the plasma. We believe this study holds significance for investigating the process under which a magnetic material magnetizes or demagnetizes under the influence of ultrashort intense laser pulses.Comment: 17 pages of text with 4 figure