QUIC-FEC: Bringing the benefits of Forward Erasure Correction to QUIC

Originally implemented by Google, QUIC gathers a growing interest by providing, on top of UDP, the same service as the classical TCP/TLS/HTTP/2 stack. The IETF will finalise the QUIC specification in 2019. A key feature of QUIC is that almost all its packets, including most of its headers, are fully encrypted. This prevents eavesdropping and interferences caused by middleboxes. Thanks to this feature and its clean design, QUIC is easier to extend than TCP. In this paper, we revisit the reliable transmission mechanisms that are included in QUIC. More specifically, we design, implement and evaluate Forward Erasure Correction (FEC) extensions to QUIC. These extensions are mainly intended for high-delays and lossy communications such as In-Flight Communications. Our design includes a generic FEC frame and our implementation supports the XOR, Reed-Solomon and Convolutional RLC error-correcting codes. We also conservatively avoid hindering the loss-based congestion signal by distinguishing the packets that have been received from the packets that have been recovered by the FEC. We evaluate its performance by applying an experimental design covering a wide range of delay and packet loss conditions with reproducible experiments. These confirm that our modular design allows the protocol to adapt to the network conditions. For long data transfers or when the loss rate and delay are small, the FEC overhead negatively impacts the download completion time. However, with high packet loss rates and long delays or smaller files, FEC allows drastically reducing the download completion time by avoiding costly retransmission timeouts. These results show that there is a need to use FEC adaptively to the network conditions.Comment: 9 pages, presented at IFIP Networking 201

Nucleation and crystallization process of silicon using Stillinger-Weber potential

We study the homogeneous nucleation process in Stillinger-Weber silicon in the NVT ensemble. A clear first-order transition from the liquid to crystal phase is observed thermodynamically with kinetic and structural evidence of the transformation. At 0.75 T_m, the critical cluster size is about 175 atoms. The lifetime distribution of clusters as a function of the maximum size their reach follows an inverse gaussian distribution as was predicted recently from the classical theory of nucleation (CNT). However, while there is a qualitative agreement with the CNT, the free energy curve obtained from the simulations differs significantly from the theoretical predictions, suggesting that the low-density liquid phase found recently could play a role in the nucleation process.Comment: 21 page

Co-creation processes of nature based solutions in hydrological modelling:case studies in the UK, Belgium and the Netherlands

Climate adaptation of brook catchments is much needed in the studied regions of England, Belgium and the Netherlands. With the continuous rise of global temperatures and global change, these regions suffer from the impacts of extreme weather events such as drought and flooding. Extreme weather and climate change impacts are spatially non-uniform, uncertain and can have different strengths at local and regional level. Therefore, cities and regions need to adapt to climate change in an ambiguous way. Accordingly, there is no uniformity in the adaptive capacity of individuals, groups within society, organisations and governments or how they can respond to current and future climate change impacts. To better understand the interlinkages in nature-based climate adaptation between the socio-economic and climate change drivers, we studied these drivers in the hydrological modelling in 3 pilot studies in the UK, the Netherlands and Belgium. Focus is on how co-creation, defined as active participation is incorporated in the hydrological modelling process, (1) within each brook catchment and (2) between the professionals, as cross border knowledge transfer. Data on the co-creation process was collected with workshops on each of the semi-annual partner meetings of each catchment. Data on the modelling process was collected by semi-structured interviews of the professionals and by using assessment of professional learning in the network (field trips). Findings on co-creation processes of nature based solutions in hydrological modelling will be compared in the UK, the Netherlands and Belgium. In the end, existing co-creation processes will be joined to a framework for co-creation which can be improved and adapted based on the gathered data. This would include: identification of stakeholder groups and their needs, the level of intended participation, the identified climate problem by the stakeholders and by the policy-makers, the planned modelling approach, the NbS etc

Efficient routing on complex networks

In this letter, we propose a new routing strategy to improve the transportation efficiency on complex networks. Instead of using the routing strategy for shortest path, we give a generalized routing algorithm to find the so-called {\it efficient path}, which considers the possible congestion in the nodes along actual paths. Since the nodes with largest degree are very susceptible to traffic congestion, an effective way to improve traffic and control congestion, as our new strategy, can be as redistributing traffic load in central nodes to other non-central nodes. Simulation results indicate that the network capability in processing traffic is improved more than 10 times by optimizing the efficient path, which is in good agreement with the analysis.Comment: 4 pages, 4 figure

Congestion and centrality in traffic flow on complex networks

The central points of communication network flow has often been identified using graph theoretical centrality measures. In real networks, the state of traffic density arises from an interplay between the dynamics of the flow and the underlying network structure. In this work we investigate the relationship between centrality measures and the density of traffic for some simple particle hopping models on networks with emerging scale-free degree distributions. We also study how the speed of the dynamics are affected by the underlying network structure. Among other conclusions, we find that, even at low traffic densities, the dynamical measure of traffic density (the occupation ratio) has a non-trivial dependence on the static centrality (quantified by "betweenness centrality"), which non-central vertices getting a comparatively large portion of the traffic.Comment: To appear in Advances in Complex System

Is the jury still out? Toward greater insight in policy learning in participatory decisoin processes-the case of Dutch citizens' juries on water management in the Rhine Basin

This article discusses the potential for policy learning offered by participatory processes, specifically so-called citizens' juries. We establish the need for policy learning by pointing to the increased complexity of water management tasks and challenges. A conceptual discussion subsequently distinguishes between cognitive, normative, and relational learning. The public participation literature suggests that participatory processes will contribute to various forms of learning. We assess the truth of this assumption on the basis of three case studies: citizens' juries on water management in the Dutch part of Rhine basin. We analyze whether the three forms of learning have occurred among jurors, and among policy makers. We find high levels of cognitive, normative, and relational levels of learning for the jurors, but relatively low levels of learning for policy makers. We analyze the reason for this divergence

Fluorescent Cell Barcoding as a Tool to Assess the Age-Related Development of Intracellular Cytokine Production in Small Amounts of Blood from Infants

Fluorescent Cell Barcoding (FCB) is a flow cytometric technique which has been used for assessing signaling proteins. This FCB technique has the potential to be applied in other multiparameter analyses. Since data on antigen (Ag)-specific T-cell immune responses, like intracellular cytokine production, are still lacking in infants because limited blood volumes can be obtained for analysis, the FCB technique could be very useful for this purpose. The objectives of this study were to modify the FCB method to be able to measure multiple Ag-specific cytokine reponses in T-cells upon simultaneous stimulation by various antigens and mitogens in small amounts of blood and to investigate the cytokine pattern of T-cell subsets in healthy infants aged six and twelve months. Blood samples, collected from 20 healthy infants aged six and twelve months, were stimulated in vitro with the antigens: phorbol-myristate-acetate (PMA), purified-protein-derivative (PPD), Tetanus-toxoid (TT), Staphylococcal-enterotoxin-B (SEB), and phytohemagglutinin (PHA). Each stimulus was barcoded by labelling with different intensities of fluorescent cell barcoding (FCB) markers. Intracellular production of interleukin-2, interferon-gamma, and tumor necrosis factor-alpha was measured simultaneously in just one blood sample of 600 µl whole blood. Significant age-related differences in cytokine production were shown for PMA, PHA, and TT in CD4+ T-cells, and for PMA, PHA, SEB, and TT in CD8+ T-cells. The intracellular cytokine production by CD4+ and CD8+ T-cells was higher at twelve months compared to six months of age for all antigens, except for PMA, which was lower at the age of twelve months. Based on the consistency in both T-cell subsets, we conclude that the new FCB method is a promising tool to investigate the age-related development of intracellular cytokine production in infants

Impact of bariatric surgery in the short and long term: a need for time-dependent dosing of drugs

Sparse information is available on pharmacokinetic changes of drugs over time after bariatric surgery. By reviewing the literature on the short- and long-term pharmacokinetic changes of drugs, several patterns were identified for 39 drugs. No relevant pharmacokinetic changes were identified for roughly a third of the drugs. Of the remaining drugs, levels were variable and partly unpredictable shortly after the surgery. In the long term, most of the drug levels remain altered, but in some cases they returned to preoperative values. Based on the changes and the efficacy-safety balance of each drug, clinicians may need to perform additional clinical monitoring for specific drugs, including measuring drug levels. This review provides suggestions for clinicians and pharmacists for specific time-dependent drug dosing advice.Pharmacolog

Enhancing Transport Efficiency by Hybrid Routing Strategy

Traffic is essential for many dynamic processes on real networks, such as internet and urban traffic systems. The transport efficiency of the traffic system can be improved by taking full advantage of the resources in the system. In this paper, we propose a dual-strategy routing model for network traffic system, to realize the plenary utility of the whole network. The packets are delivered according to different "efficient routing strategies" [Yan, et al, Phys. Rev. E 73, 046108 (2006)]. We introduce the accumulate rate of packets, {\eta} to measure the performance of traffic system in the congested phase, and propose the so-called equivalent generation rate of packet to analyze the jamming processes. From analytical and numerical results, we find that, for suitable selection of strategies, the dual- strategy system performs better than the single-strategy system in a broad region of strategy mixing ratio. The analytical solution to the jamming processes is verified by estimating the number of jammed nodes, which coincides well with the result from simulation.Comment: 6 pages, 3 figure