D-Strings on D-Manifolds

We study the mechanism for appearance of massless solitons in type II string compactifications. We find that by combining $T$-duality with strong/weak duality of type IIB in 10 dimensions enhanced gauge symmetries and massless solitonic hypermultiplets encountered in Calabi-Yau compactifications can be studied perturbatively using D-strings (the strong/weak dual to type IIB string) compactified on ``D-manifolds''. In particular the nearly massless solitonic states of the type IIB compactifications correspond to elementary states of D-strings. As examples we consider the D-string description of enhanced gauge symmetries for type IIA string compactification on ALE spaces with $A_n$ singularities and type IIB on a class of singular Calabi-Yau threefolds. The class we study includes as a special case the conifold singularity in which case the perturbative spectrum of the D-string includes the expected massless hypermultiplet with degeneracy one.Comment: 23 pages, with 3 figures. A compact example is adde

Reduction of circulating cholesterol and apolipoprotein levels during sepsis

Sepsis with multiple organ failure is frequently associated with a substantial decrease of cholesterol levels. This decrease of cholesterol is strongly associated with mortality suggesting a direct relation between inflammatory conditions and altered cholesterol homeostasis. The host response during sepsis is mediated by cytokines and growth factors, which are capable of influencing lipid metabolism. Conversely lipoproteins are also capable of modulating cytokine production during the inflammatory response. Therefore the decrease in circulating cholesterol levels seems to play a crucial role in the pathophysiology of sepsis. In this review the interaction between cytokines and lipid metabolism and its clinical consequences will be discussed

(0,2) Deformations of Linear Sigma Models

We study (0,2) deformations of a (2,2) supersymmetric gauged linear sigma model for a Calabi-Yau hypersurface in a Fano toric variety. In the non-linear sigma model these correspond to some of the holomorphic deformations of the tangent bundle on the hypersurface. Combinatorial formulas are given for the number of these deformations, and we show that these numbers are exchanged by mirror symmetry in a subclass of the models.Comment: 35 pages; uses xy-fig; typos fixed, acknowledgments adde

Heterotic Compactification, An Algorithmic Approach

We approach string phenomenology from the perspective of computational algebraic geometry, by providing new and efficient techniques for proving stability and calculating particle spectra in heterotic compactifications. This is done in the context of complete intersection Calabi-Yau manifolds in a single projective space where we classify positive monad bundles. Using a combination of analytic methods and computer algebra we prove stability for all such bundles and compute the complete particle spectrum, including gauge singlets. In particular, we find that the number of anti-generations vanishes for all our bundles and that the spectrum is manifestly moduli-dependent.Comment: 36 pages, Late

Early symptoms in spinocerebellar ataxia type 1, 2, 3, and 6.

Abstract: Onset of genetically determined neurodegenerative diseases is difficult to specify because of their insidious and slowly progressive nature. This is especially true for spinocerebellar ataxia (SCA) because of varying affection of many parts of the nervous system and huge variability of symptoms. We investigated early symptoms in 287 patients with SCA1, SCA2, SCA3, or SCA6 and calculated the influence of CAG repeat length on age of onset depending on (1) the definition of disease onset, (2) people defining onset, and (3) duration of symptoms. Gait difficulty was the initial symptom in two-thirds of patients. Double vision, dysarthria, impaired hand writing, and episodic vertigo preceded ataxia in 4% of patients, respectively. Frequency of other early symptoms did not differ from controls and was regarded unspecific. Data about disease onset varied between patients and relatives for 1 year or more in 44% of cases. Influence of repeat length on age of onset was maximum when onset was defined as beginning of permanent gait disturbance and cases with symptoms for more than 10 years were excluded. Under these conditions, CAG repeat length determined 64% of onset variability in SCA1, 67% in SCA2, 46% in SCA3, and 41% in SCA6 demonstrating substantial influence of nonrepeat factors on disease onset in all SCA subtypes. Identification of these factors is of interest as potential targets for disease modifying compounds. In this respect, recognition of early symptoms that develop before onset of ataxia is mandatory to determine the shift from presymptomatic to affected status in SCA

Closed string tachyons, flips and conifolds

Following the analysis of tachyons and orbifold flips described in hep-th/0412337, we study nonsupersymmetric analogs of the supersymmetric conifold singularity and show using their toric geometry description that they are nonsupersymmetric orbifolds of the latter. Using linear sigma models, we see that these are unstable to localized closed string tachyon condensation and exhibit flip transitions between their two small resolutions (involving 2-cycles), in the process mediating mild dynamical topology change. Our analysis shows that the structure of these nonsupersymmetric conifolds as quotients of the supersymmetric conifold obstructs the 3-cycle deformation of such singularities, suggesting that these nonsupersymmetric conifolds decay by evolving towards their stable small resolutions.Comment: Latex, 22 pgs, 2 figs. v4: matches JHEP version, 29 pgs, 3 figures, more elaborate Introduction, various clarifications adde