Design bugs out: a real world investigation of hospital bedside chairs and commodes

This paper was presented at the the 17th World Congress on Ergonomics (IEA’09) in August 2009, Beijing, China.Healthcare Associated Infections (HCAIs) can affect both patients and healthcare workers. They are difficult to treat, and can complicate illnesses, cause distress, and even lead to death. HCAIs are also a huge financial burden on the UK’s National Health Service (NHS). Aiming to identify and fast-track the implementation of new technologies and design-led innovations to combat HCAIs, the UK’s Department of Health (DH), in partnership with the Purchasing and Supply Agency of the NHS and the Design Council, launched the Challenge ‘Design Bugs Out’ in September 2008. The design challenge invited teams of designers and manufacturers to redesign hospital furniture and equipment to make them easier to keep clean, and so help reduce patients’ exposure to HCAIs and improve their hospital experience. As a research partner of a winning team PearsonLloyd Design Consultancy and Kirton Healthcare Manufacturing) selected to answer this Challenge, the Human-Centred Design Institute (HCDI) at Brunel University conducted intensive design research focusing on bedside chairs and on-ward commodes. The research findings were used to inform the design process of the ward objects, towards the delivery of working prototypes in April 2009, to be displayed in a public exhibition and then taken on a national tour of selected hospitals for trial. This paper reports on the research process, aiming to extract useful information on a human-centred approach to healthcare design innovation.The Design Council, Department of Healt

Crystal structure of Schmallenberg orthobunyavirus nucleoprotein-RNA complex reveals a novel RNA sequestration mechanism

Schmallenberg virus (SBV) is a newly emerged orthobunyavirus (family Bunyaviridae) that has caused severe disease in the offspring of farm animals across Europe. Like all orthobunyaviruses, SBV contains a tripartite negative-sense RNA genome that is encapsidated by the viral nucleocapsid (N) protein in the form of a ribonucleoprotein complex (RNP). We recently reported the three-dimensional structure of SBV N that revealed a novel fold. Here we report the crystal structure of the SBV N protein in complex with a 42-nt-long RNA to 2.16 Å resolution. The complex comprises a tetramer of N that encapsidates the RNA as a cross-shape inside the protein ring structure, with each protomer bound to 11 ribonucleotides. Eight bases are bound in the positively charged cleft between the N- and C-terminal domains of N, and three bases are shielded by the extended N-terminal arm. SBV N appears to sequester RNA using a different mechanism compared with the nucleoproteins of other negative-sense RNA viruses. Furthermore, the structure suggests that RNA binding results in conformational changes of some residues in the RNA-binding cleft and the N- and C-terminal arms. Our results provide new insights into the novel mechanism of RNA encapsidation by orthobunyaviruses

Z-graded weak modules and regularity

It is proved that if any Z-graded weak module for vertex operator algebra V is completely reducible, then V is rational and C_2-cofinite. That is, V is regular. This gives a natural characterization of regular vertex operator algebras.Comment: 9 page

Binding between endohedral Na atoms in Si clathrate I; a first principles study

We investigate the binding nature of the endohedral sodium atoms with the ensity functional theory methods, presuming that the clathrate I consists of a sheaf of one-dimensional connections of Na@Si$_{24}$ cages interleaved in three perpendicular directions. Each sodium atom loses 30% of the 3s$^1$ charge to the frame, forming an ionic bond with the cage atoms; the rest of the electron contributes to the covalent bond between the nearest Na atoms. The presumption is proved to be valid; the configuration of the two Na atoms in the nearest Si$_{24}$ cages is more stable by 0.189 eV than that in the Si$_{20}$ and Si$_{24}$ cages. The energy of the beads of the two distorted Na atoms is more stable by 0.104 eV than that of the two infinitely separated Na atoms. The covalent bond explains both the preferential occupancies in the Si$_{24}$ cages and the low anisotropic displacement parameters of the endohedral atoms in the Si$_{24}$ cages in the [100] directions of the clathrate I.Comment: First page: Affiliation added to PDF and PS versio

Single-particle machine for quantum thermalization

The long time accumulation of the \textit{random} actions of a single particle "reservoir" on its coupled system can transfer some temperature information of its initial state to the coupled system. This dynamic process can be referred to as a quantum thermalization in the sense that the coupled system can reach a stable thermal equilibrium with a temperature equal to that of the reservoir. We illustrate this idea based on the usual micromaser model, in which a series of initially prepared two-level atoms randomly pass through an electromagnetic cavity. It is found that, when the randomly injected atoms are initially prepared in a thermal equilibrium state with a given temperature, the cavity field will reach a thermal equilibrium state with the same temperature as that of the injected atoms. As in two limit cases, the cavity field can be cooled and "coherently heated" as a maser process, respectively, when the injected atoms are initially prepared in ground and excited states. Especially, when the atoms in equilibrium are driven to possess some coherence, the cavity field may reach a higher temperature in comparison with the injected atoms. We also point out a possible experimental test for our theoretical prediction based on a superconducting circuit QED system.Comment: 9 pages,4 figures

End-to-End Learning of Video Super-Resolution with Motion Compensation

Learning approaches have shown great success in the task of super-resolving an image given a low resolution input. Video super-resolution aims for exploiting additionally the information from multiple images. Typically, the images are related via optical flow and consecutive image warping. In this paper, we provide an end-to-end video super-resolution network that, in contrast to previous works, includes the estimation of optical flow in the overall network architecture. We analyze the usage of optical flow for video super-resolution and find that common off-the-shelf image warping does not allow video super-resolution to benefit much from optical flow. We rather propose an operation for motion compensation that performs warping from low to high resolution directly. We show that with this network configuration, video super-resolution can benefit from optical flow and we obtain state-of-the-art results on the popular test sets. We also show that the processing of whole images rather than independent patches is responsible for a large increase in accuracy.Comment: Accepted to GCPR201