Some current measurements in the Sargasso Sea

Also published as: Deep-Sea Research 12 (1965): 805-814Long-term current measurements at depths of 50 and 100m obtained with Richardson current meters at two deep-water moorings south of Bermuda are reported. The records are dominated by anticyclonic rotations which appear and degenerate, possibly in response to the passage of storms. Spectral analysis of the records indicates that this motion has a period of 24 hours at a depth of 50 m, and 25·3 hours at a depth of 100m. No explanation is given to account for this difference in period over a 50-m separation. Both records indicate the existence of semidiurnal tidal motion. The long-term motions at both depths indicate a systematic change in the net direction of flow over a three-month period.The Office of Naval Research under Contract Nonr-2196(00) NR 083-004

Synthetic aspects of host-guest chemistry

Imperial Users onl

Refining the genetics of muscular dystrophies with defective glycosylation of dystroglycan

The aberrant glycosylation of α-dystroglycan is associated with a subset of clinically heterogeneous muscular dystrophies collectively referred to as dystroglycanopathies. Mutations in seven genes are currently known to result in these autosomal recessive disorders. To define the mutation frequency and clinical phenotypes associated with mutations in five of these genes, I analysed a large cohort of patients. This study redefined the clinical spectrum associated with mutations in POMT1, POMT2, POMGNT1, FKTN and LARGE. Mutations in these genes were detected in approximately a third of all cases indicating that, after the exclusion of FKRP involvement, the majority of patients with a dystroglycanopathy harbour mutations in novel genes. In order to identify novel genes in these disorders I applied a candidate gene approach to the whole genome. Genes known to be causative in dystroglycanopathy animal models and those predicted to function within the pathway of dystroglycan glycosylation were investigated. Mutation screening indicated that defects in GYLTL1B, β3GNT1, WWP1, GYG1, GYG2, MGAT5B and DAG1 are not frequent causes of human dystroglycanopathy. In order to evaluate the function of a subset of candidate genes, I optimised a cell culture model of dystroglycanopathy. Using a ribonucleotide interference based strategy, the expression of candidate genes were modulated in a mouse myogenic cell line. The down regulation of β3gnt1 induced a marked reduction in the glyco-epitope present on α-dystroglycan. This finding confirms β3gnt1 as a key enzyme functioning in the pathway of α-dystroglycan glycosylation. In addition, I combined the use of high density single nucleotide polymorphism genotyping platforms, expression microarrays and sequencing data to investigate the cause of disease in a small consanguineous pedigree. In summary, this data set has refined genotype-phenotype correlations of known causative genes as well as investigated the involvement of novel loci in muscular dystrophies with defective glycosylation of dystroglycan

Development of the health and economic consequences of smoking interactive model

Objective-To describe the health and economic consequences of smoking model, a user friendly, web based tool, designed to estimate the health and economic outcomes associated with smoking and the benefits of smoking cessation. Results-An overview of the development of the model equations and user interface is given, and data from the UK are presented as an example of the model outputs. These results show that a typical smoking cessation strategy costs approximately pound 1200 per life year saved and pound 22 000 per death averted. Conclusions-The model successfully captures the complexity required to model smoking behaviour and associated mortality, morbidity, and health care costs. Furthermore, the interface provides the results in a simple and flexible way so as to be useful to a variety of audiences and to simulate a variety of smoking cessation methods

ON AND OFF - LINE QUALITY CONTROL FOR PRODUCT DESIGN AND MANUFACTURING PROCESSES

The Taguchi methodology which may be applied as off-line quality control in the product design stage or, as on-line quality control during production is presented. As an off-line quality improvement strategy, it is a preventive measure at the product or manufacturing systems design stage which has the capability of making the product design robust. As an on-line quality improvement strategy, it assists in diagnosing the cause of the variation during production for the purpose of either eliminating the cause of variation or redesigning the product/process to make the product robust against the effect of the variation. The results of a case study presented using a computer program developed show that the Taguchi methodology can lead to substantial improvements

Evaluation of protein supplement available to Tennessee farmers fed with whole shelled corn in finishing long yearling cattle

The data used in this study were obtained from 160 long yearling feeder steers weighing between 600 and 750 lbs. and fed whole shelled corn finishing rations supplemented with four different protein sources as to comprise the finishing rations. The variables, frame size, increase in fat thickness, average daily gain, total gain per pen, average daily corn consumption, average corn conversion, carcass weight, rib eye area, fat thickness, percent kidney, pelvic, and heart fat, yield grade, marbling, and quality grade were subjected to a least squares regression analysis as dependent variables to detect significant differences between the treatments. The variables, average daily gain, total gain per pen, average daily com consumption, average corn conversion, carcass weight, and yield grade were found to be (P \u3c .05) different for treatment. Duncan\u27s Multiple Range Test was conducted to rank the treatments for these variables. Previous workers have not made such comparisons as these but from these data one could conclude that the (P \u3c .05) differences in average daily gain were due to the protein supplements. The relation-ship of carcass weight, rib eye area, and percent kidney, pelvic, and heart fat in replication effects, according to these data, would appear to be that the heavier carcasses had larger rib eye areas with less kidney, pelvic, and heart fat

Religion, Politics, and Sugar: The Mormon Church, the Federal Government, and the Utah-Idaho Sugar Company, 1907 to 1921

One famous target of Progressive Era attempts to rein in monopolistic big business was the eastern Sugar Trust. Less known is how federal regulators also tried to break monopoly control over beet sugar in the West by going after the Utah-Idaho Sugar Company, a business supported and controlled by the Latter-day Saints church and run by Mormon authorities. As sugar beet agriculture boomed, the Mormon church\u27s involvement led directly to monopolistic practices by Utah-Idaho Sugar and to federal investigations. Church leaders encouraged members, a majority population in much of the intermountain West, to patronize the company exclusively, as suppliers and consumers. As early as 1890, Mormon church president Wilford Woodruff had called missionaries to raise money for the fledgling company and asserted divine inspiration for church support. Utah-Idaho bridged the cooperative, theocratic, self-sufficient economic model of nineteenth-century Mormonism and the integration of the Mormon West into the national market economy. Religion, Politics, and Sugar shows, through the example of an important western business, how national commercial, political, and legal forces in the early twentieth century came west and, more specifically, how they affected the important role the Mormon church played in economic affairs in the region.https://digitalcommons.usu.edu/usupress_pubs/1043/thumbnail.jp

Alien Registration- Godfrey, Delia C. (Bowerbank, Piscataquis County)

https://digitalmaine.com/alien_docs/10194/thumbnail.jp

Religion, Politics, and Sugar: The Mormon Church, the Federal Government, and the Utah-Idaho Sugar Company, 1907 to 1921

One famous target of Progressive Era attempts to rein in monopolistic big business was the eastern Sugar Trust. Less known is how federal regulators also tried to break monopoly control over beet sugar in the West by going after the Utah-Idaho Sugar Company, a business supported and controlled by the Latter-day Saints church and run by Mormon authorities. As sugar beet agriculture boomed, the Mormon church's involvement led directly to monopolistic practices by Utah-Idaho Sugar and to federal investigations. Church leaders encouraged members, a majority population in much of the intermountain West, to patronize the company exclusively, as suppliers and consumers. As early as 1890, Mormon church president Wilford Woodruff had called missionaries to raise money for the fledgling company and asserted divine inspiration for church support. Utah-Idaho bridged the cooperative, theocratic, self-sufficient economic model of nineteenth-century Mormonism and the integration of the Mormon West into the national market economy. Religion, Politics, and Sugar shows, through the example of an important western business, how national commercial, political, and legal forces in the early twentieth century came west and, more specifically, how they affected the important role the Mormon church played in economic affairs in the region