1,399 research outputs found
Measuring Galaxy Environments with Deep Redshift Surveys
We study the applicability of several galaxy environment measures
(n^th-nearest-neighbor distance, counts in an aperture, and Voronoi volume)
within deep redshift surveys. Mock galaxy catalogs are employed to mimic
representative photometric and spectroscopic surveys at high redshift (z ~ 1).
We investigate the effects of survey edges, redshift precision, redshift-space
distortions, and target selection upon each environment measure. We find that
even optimistic photometric redshift errors (\sigma_z = 0.02) smear out the
line-of-sight galaxy distribution irretrievably on small scales; this
significantly limits the application of photometric redshift surveys to
environment studies. Edges and holes in a survey field dramatically affect the
estimation of environment, with the impact of edge effects depending upon the
adopted environment measure. These edge effects considerably limit the
usefulness of smaller survey fields (e.g. the GOODS fields) for studies of
galaxy environment. In even the poorest groups and clusters, redshift-space
distortions limit the effectiveness of each environment statistic; measuring
density in projection (e.g. using counts in a cylindrical aperture or a
projected n^th-nearest-neighbor distance measure) significantly improves the
accuracy of measures in such over-dense environments. For the DEEP2 Galaxy
Redshift Survey, we conclude that among the environment estimators tested the
projected n^th-nearest-neighbor distance measure provides the most accurate
estimate of local galaxy density over a continuous and broad range of scales.Comment: 17 pages including 16 figures, accepted to Ap
The Cepheid distance to the maser-host galaxy NGC 4258: Studying systematics with the Large Binocular Telescope
We identify and phase a sample of 81 Cepheids in the maser-host galaxy NGC
4258 using the Large Binocular Telescope (LBT), and obtain calibrated mean
magnitudes in up to 4 filters for a subset of 43 Cepheids using archival HST
data. We employ 3 models to study the systematic effects of extinction, the
assumed extinction law, and metallicity on the Cepheid distance to NGC 4258. We
find a correction to the Cepheid colors consistent with a grayer extinction law
in NGC 4258 compared to the Milky Way (), although we believe this is
indicative of other systematic effects. If we combine our Cepheid sample with
previously known Cepheids, we find a significant metallicity adjustment to the
distance modulus of mag/dex, for the Zaritsky et
al. (1994) metallicity scale, as well as a weak trend of Cepheid colors with
metallicity. Conclusions about the absolute effect of metallicity on Cepheid
mean magnitudes appear to be limited by the available data on the metallicity
gradient in NGC 4258, but our Cepheid data require at least some metallicity
adjustment to make the Cepheid distance consistent with independent distances
to the LMC and NGC 4258. From our ensemble of models and the geometric maser
distance of NGC 4258 ( mag), we estimate
mag ( kpc).Comment: Accepted for publication in MNRAS. 28 pages, 13 figures, 11 tables. A
brief video summarizing the key results of this paper can be found at
http://youtu.be/ICTTNyxZ89
A Powerful New Quantitative Genetics Platform, Combining Caenorhabditis elegans High-Throughput Fitness Assays with a Large Collection of Recombinant Strains.
The genetic variants underlying complex traits are often elusive even in powerful model organisms such as Caenorhabditis elegans with controlled genetic backgrounds and environmental conditions. Two major contributing factors are: (1) the lack of statistical power from measuring the phenotypes of small numbers of individuals, and (2) the use of phenotyping platforms that do not scale to hundreds of individuals and are prone to noisy measurements. Here, we generated a new resource of 359 recombinant inbred strains that augments the existing C. elegans N2xCB4856 recombinant inbred advanced intercross line population. This new strain collection removes variation in the neuropeptide receptor gene npr-1, known to have large physiological and behavioral effects on C. elegans and mitigates the hybrid strain incompatibility caused by zeel-1 and peel-1, allowing for identification of quantitative trait loci that otherwise would have been masked by those effects. Additionally, we optimized highly scalable and accurate high-throughput assays of fecundity and body size using the COPAS BIOSORT large particle nematode sorter. Using these assays, we identified quantitative trait loci involved in fecundity and growth under normal growth conditions and after exposure to the herbicide paraquat, including independent genetic loci that regulate different stages of larval growth. Our results offer a powerful platform for the discovery of the genetic variants that control differences in responses to drugs, other aqueous compounds, bacterial foods, and pathogenic stresses
The emerging landscape of reimbursement of regenerative medicine products in the UK: publications, policies and politics
Aims
This paper aims to map the trends and analyse key institutional dynamics that are constituting the policies for reimbursement of Regenerative Medicine (RM), especially in the UK.
Materials & Methods
Two quantitative publications studies using Google Scholar and a qualitative study based on a larger study of 43 semi- structured interviews.
Results
Reimbursement has been a growing topic of publications specific to RM and independent from orphan drugs. Risk- sharing schemes receive attention amongst others for dealing with RM reimbursement. Trade organisations have been especially involved on RM reimbursement issues and have proposed solutions.
Conclusion
The policy and institutional landscape of reimbursement studies in RM is a highly variegated and conflictual one and in its infancy
Kiloparsec-scale Spatial Offsets in Double-peaked Narrow-line Active Galactic Nuclei. I. Markers for Selection of Compelling Dual Active Galactic Nucleus Candidates
Merger-remnant galaxies with kpc-scale separation dual active galactic nuclei
(AGNs) should be widespread as a consequence of galaxy mergers and triggered
gas accretion onto supermassive black holes, yet very few dual AGNs have been
observed. Galaxies with double-peaked narrow AGN emission lines in the Sloan
Digital Sky Survey are plausible dual AGN candidates, but their double-peaked
profiles could also be the result of gas kinematics or AGN-driven outflows and
jets on small or large scales. To help distinguish between these scenarios, we
have obtained spatial profiles of the AGN emission via follow-up long-slit
spectroscopy of 81 double-peaked narrow-line AGNs in SDSS at 0.03 < z < 0.36
using Lick, Palomar, and MMT Observatories. We find that all 81 systems exhibit
double AGN emission components with ~kpc projected spatial separations on the
sky, which suggests that they are produced by kpc-scale dual AGNs or kpc-scale
outflows, jets, or rotating gaseous disks. In addition, we find that the
subsample (58%) of the objects with spatially compact emission components may
be preferentially produced by dual AGNs, while the subsample (42%) with
spatially extended emission components may be preferentially produced by AGN
outflows. We also find that for 32% of the sample the two AGN emission
components are preferentially aligned with the host galaxy major axis, as
expected for dual AGNs orbiting in the host galaxy potential. Our results both
narrow the list of possible physical mechanisms producing the double AGN
components, and suggest several observational criteria for selecting the most
promising dual AGN candidates from the full sample of double-peaked narrow-line
AGNs. Using these criteria, we determine the 17 most compelling dual AGN
candidates in our sample.Comment: 12 pages, 8 figures, published in ApJ. Modified from original version
to reflect referee's comment
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