The magnitude and impact of the Youngest Toba Tuff super-eruption

Super-eruptions, orders of magnitude larger than biggest eruptions experienced in historic times, have devastated wide areas by pyroclastic flows, covered continent-size areas by ash fallout, and injected large quantities of aerosols into the stratosphere affecting global climate. The Youngest Toba Tuff (YTT) is the largest known super-eruption in the Quaternary. Here we reconstructed the ultra-distal volcanic ash dispersal during this super-eruption using a computational ash dispersal model, which provides insights into the eruption dynamics and the impact of the event. The method uses a 3D time-dependent tephra dispersion model, a set of wind fields, and several tens of thickness measurements of the YTT tephra deposit. Results reveal that the YTT eruption dispersed ∼8600km3 (∼3800km3 dense rock equivalent, DRE) of ash, covering ∼40 million km2 with more than 5mm of ash. These new fallout volume estimations indicate that the total volume of the material erupted (including the massive pyroclastic density current (PDC), 1500km3 DRE, deposits on Sumatra) was ∼5300km3 DRE. Simulation results indicate that the eruption had a very large mass flow rate and that the umbrella cloud, associated with the eruption plume, spread as an enormous gravity current around the neutral buoyancy level. The YTT tephra forms a key chronostratigraphic marker in the sedimentary sequences, and is particularly useful for constraining the age of the palaeoenvironmental and archeological records, and synchronizing these archives to investigate temporal relationships. These new constraints on the extent of the YTT deposit are therefore particularly useful for cryptotephra studies that aim to find nonvisible tephra layers for these chronological purposes. This method used to constrain volcanological parameters of eruptions in the past provides insights into the dispersal processes, and allows the amount of volatiles released to be estimated which is crucial to assessing the impact of such events

Walk well:a randomised controlled trial of a walking intervention for adults with intellectual disabilities: study protocol

Background - Walking interventions have been shown to have a positive impact on physical activity (PA) levels, health and wellbeing for adult and older adult populations. There has been very little work carried out to explore the effectiveness of walking interventions for adults with intellectual disabilities. This paper will provide details of the Walk Well intervention, designed for adults with intellectual disabilities, and a randomised controlled trial (RCT) to test its effectiveness. Methods/design - This study will adopt a RCT design, with participants allocated to the walking intervention group or a waiting list control group. The intervention consists of three PA consultations (baseline, six weeks and 12 weeks) and an individualised 12 week walking programme. A range of measures will be completed by participants at baseline, post intervention (three months from baseline) and at follow up (three months post intervention and six months from baseline). All outcome measures will be collected by a researcher who will be blinded to the study groups. The primary outcome will be steps walked per day, measured using accelerometers. Secondary outcome measures will include time spent in PA per day (across various intensity levels), time spent in sedentary behaviour per day, quality of life, self-efficacy and anthropometric measures to monitor weight change. Discussion - Since there are currently no published RCTs of walking interventions for adults with intellectual disabilities, this RCT will examine if a walking intervention can successfully increase PA, health and wellbeing of adults with intellectual disabilities

The GALEX UV emission in shell galaxies: tracing galaxy "rejuvenation" episodes

We present the GALEX far FUV and near NUV ultraviolet imaging of three nearby shell galaxies, namely NGC 2865, NGC 5018 and NGC 7135. The system of shells and fine structures visible in the optical is detected in the NUV image of NGC 2865 and in both NUV and FUV images of NGC 7135. The NUV image of NGC 5018 does not present shell structures. We detect absorption features in the nuclear region of all three galaxies. NGC 2865 has a nearly flat colour profile with (FUV-NUV)~2 throughout the whole galaxy. NGC 7135 is blue in the center (FUV-NUV)~0 and as red as (FUV-NUV)~1.5 in the outskirts, including the faint shell-like feature. We investigate the ability of the nuclear GALEX (FUV-NUV) colour to provide information about rejuvenation phenomena in the stellar populations of the shell galaxies. To this aim, we derive from theory the relationship between the Mg2, Hbeta, HgammaA, HdeltaA Lick line-strength indices and the (FUV-NUV) colour. We extend the study to a sample of early-type galaxies with emission lines in their optical spectra (Annibali et al. 2007). In the index vs.(FUV-NUV) colour diagrams, most of the galaxies are well explained by passively evolving SSPs. On the average, ages and metallicities of the galaxies in our sample estimated from optical line-strength indices are consistent with those inferred from the (FUV-NUV) colour. In general, all the colours but for (FUV-NUV) and (FUV-V), become nearly age insensitive when 1-2 Gyr have elapsed from the last star forming event. Considering composite stellar population models with a recent burst of star formation, we suggest that the position of the NGC 7135 and NGC 2865 nuclei in the (FUV-NUV)-Hbeta plane could be explained in term of a recent rejuvenation episode. (Abridged)Comment: Accepted for publication in MNRAS Main Journal, 21 pages, 15 figure

Effect of Carnitine and herbal mixture extract on obesity induced by high fat diet in rats

<p>Abstract</p> <p>Background</p> <p>Obesity-associated type 2 diabetes is rapidly increasing throughout the world. It is generally recognized that natural products with a long history of safety can modulate obesity.</p> <p>Aim</p> <p>To investigate the development of obesity in response to a high fat diet (HFD) and to estimate the effect of L-carnitine and an Egyptian Herbal mixture formulation (HMF) (consisting of T. chebula, Senae, rhubarb, black cumin, aniseed, fennel and licorice) on bodyweight, food intake, lipid profiles, renal, hepatic, cardiac function markers, lipid Peroxidation, and the glucose and insulin levels in blood and liver tissue in rats.</p> <p>Method</p> <p>White male albino rats weighing 80-90 gm, 60 days old. 10 rats were fed a normal basal diet (Cr), 30 rats fed a high-fat diet (HFD) for 14 weeks during the entire study. Rats of the HFD group were equally divided into 3 subgroups each one include 10 rats. The first group received HFD with no supplement (HFD), the 2^ndgroup HFD+L-carnitine and the third group received HFD+HMF. Carnitine and HMF were administered at 10^thweek (start time for treatments) for 4 weeks.</p> <p>Body weight, lipid profile & renal function (urea, uric acid creatinine) ALT & AST activities, cardiac markers, (LDH, C.K-NAC and MB) the oxidative stress marker reduced glutathione (GSH), and Malondialdehyde (MDA) catalase activity, in addition to glucose, insulin, and insulin resistance in serum & tissues were analyzed.</p> <p>Results</p> <p>Data showed that feeding HFD diet significantly increased final body weight, triglycerides (TG), total cholesterol, & LDL concentration compared with controls, while significantly decreasing HDL; meanwhile treatment with L-carnitine, or HMF significantly normalized the lipid profile.</p> <p>Serum ALT, urea, uric acid, creatinine, LDH, CK-NAC, CK-MB were significantly higher in the high fat group compared with normal controls; and administration of L-carnitine or herbal extract significantly lessened the effect of the HFD. Hyperglycemia, hyperinsulinemia, and high insulin resistance (IR) significantly increased in HFD in comparison with the control group. The treatment with L-carnitine or HMF improved the condition. HFD elevated hepatic MDA and lipid peroxidation associated with reduction in hepatic GSH and catalase activity; whereas administration of L-carnitine or herbal extract significantly ameliorated these hepatic alterations.</p> <p>Conclusion</p> <p>HFD induced obesity associated with a disturbed lipid profile, defective antioxidant stability, and high values of IR parameters; this may have implications for the progress of obesity related problems. Treatment with L-carnitine, or HMF extract improved obesity and its associated metabolic problems in different degrees. Also HMF has antioxidant, hypolipidaemic insulin sensitizing effects. Moreover HMF might be a safe combination on the organs whose functions were examined, as a way to surmount the obesity state; and it has a distinct anti-obesity effect.</p