Appropriate technology for Aboriginal Enterprise Development

RADG has been developing appropriate health technology for use in remote communities in Australia. The greatest need for these technologies has been in Aboriginal communities. In developing appropriate technical artifacts, RADG has confronted two problems. Firstly we require good contact with remote communities for consultation and feedback. Secondly, part of making artifacts appropriate for under-developed countries or regions, is the need to include employment and self-determination as part of the benefits of a technology

Biological functions of CDK5 and potential CDK5 targeted clinical treatments.

Cyclin dependent kinases are proline-directed serine/threonine protein kinases that are traditionally activated upon association with a regulatory subunit. For most CDKs, activation by a cyclin occurs through association and phosphorylation of the CDK\u27s T-loop. CDK5 is unusual because it is not typically activated upon binding with a cyclin and does not require T-loop phosphorylation for activation, even though it has high amino acid sequence homology with other CDKs. While it was previously thought that CDK5 only interacted with p35 or p39 and their cleaved counterparts, Recent evidence suggests that CDK5 can interact with certain cylins, amongst other proteins, which modulate CDK5 activity levels. This review discusses recent findings of molecular interactions that regulate CDK5 activity and CDK5 associated pathways that are implicated in various diseases. Also covered herein is the growing body of evidence for CDK5 in contributing to the onset and progression of tumorigenesis

Alternate cyclin D1 mRNA splicing modulates P27\u3csup\u3eKlP1\u3c/sup\u3e binding and cell migration

Cyclin D1 is an important cell cycle regulator but in cancer its overexpression also increases cellular migration mediated by p27KlP1 stabilization and RhoA inhibition. Recently, a common polymorphism at the exon 4-intron 4 boundary of the human cyclin D1 gene within a splice donor region was associated with an altered risk of developing cancer. Altered RNA splicing caused by this polymorphism gives rise to a variant cyclin D1 isoform termed cyclin D1b, which has the same N-terminus as the canonical cyclin D1a isoform but a distinct C-terminus. In this study we show that these different isoforms have unique properties with regard to the cellular migration function of cyclin D1. Whereas they displayed little difference in transcriptional co-repression assays on idealized reporter genes, microarray cDNA expression analysis revealed differential regulation of genes including those that influence cellular migration. Additionally, while cyclin D1a stabilized p27KIP1 and inhibited RhoA-induced ROCK kinase activity, promoting cellular migration, cyclin D1b failed to stabilize p27KIP1 or inhibit ROCK kinase activity and had no effect on migration. Our findings argue that alternate splicing is an important determinant of the function of cyclin D1 in cellular migration

Portable optometry: You can do eye exams anywhere

The recent advances m portable optometric equipment and technology offer a greater potential than ever before for optometrists to leave their offices and increase their services and patient base. In this paper, we introduce manangement techniques for portable optometry along with various suggested forms. We discuss and list selected out of office equipment and discuss special services such as vision therapy, consulting, dispensing and contact lenses that can be done outside of the office. We conclude that full-scope optometry can be accomplished out of the office

Controlled conversion approaches to selective laser sintering (SLS) printing of high Tg thermosets

Thermoset materials display superior physical and mechanical properties as compared to commonly printed semi-crystalline thermoplastics, yet they typically are not printed by selective laser sintering (SLS). This is because these materials require a post-print thermal cure above Tg to achieve maximal properties. However, such thermal treatment typically results in re-melting of the printed part. Current approaches to printing thermoset materials by this technique have largely relied on infiltrating a porous thermoplastic printed object with a low viscosity reactive resin which is then cured. More recently, direct printing of thermoset materials was also demonstrated, but these approaches require very rapid curing which is often also associated with reduced shelf-life and/or high filler content which may not be desired. Other higher temperature thermoplastics with superior properties (PPS and PEEK) have also been printed using this technique, but the printing of these requires specially designed high-temperature (200-300°C) printing chambers. Please click Additional Files below to see the full abstract

Acute military psychiatric casualties from the war in Iraq

Background: The view that most military personnel evacuated from war zones are suffering from combat stress reactions, or are otherwise traumatised by the horrors of war, has an impact on all aspects of military psychiatry. Aims: To delineate the reasons for psychiatric aeromedical evacuation from Iraq from the start of build-up of UK forces in January 2003 until the end of October that year, 6 months after the end of formal hostilities. Method: A retrospective study was conducted of field and in-patient psychiatric assessments of 116 military personnel evacuated to the UK military psychiatric in-patient facility in Catterick Garrison. Results: Evacuees were mainly non-combatants (69%). A significant proportion were in reserve service (21%) and had a history of contact with mental health services (37%). Only 3% had a combat stress reaction. In over 85% of cases evacuation was for low mood attributed to separation from friends or family, or difficulties adjusting to the environment. Conclusions: These findings have implications especially for screening for suitability for deployment, and for understanding any longer-term mental health problems arising in veterans from Iraq

Phomopsis Stem Canker of Sunflower in North America: Correlation with Climate and Solutions Through Breeding and Management

Climate change is occurring in the central US and is interacting with agroecological factors to increase biotic stress in sunflower. Certain species of Diaporthe cause Phomopsis stem canker in sunflower and other dicotyledonous weeds and crops. The increase in precipitation already observed in the states of North Dakota, South Dakota, and Minnesota have increased the chances of outbreaks of necrotrophic pathogens, like Diaporthe. We discuss how climate trends, combined with technological, management, and economic interactions, are correlated with increasing incidence of Phomopsis stem canker in these and adjacent areas in North America. Further, we discuss management options and the role of improved sunflower genetics in reducing Phomopsis stem canker outbreak risk

The SCARE 2020 Guideline: Updating Consensus Surgical CAse REport (SCARE) Guidelines

INTRODUCTION: The SCARE Guidelines were first published in 2016 and were last updated in 2018. They provide a structure for reporting surgical case reports and are used and endorsed by authors, journal editors and reviewers, in order to increase robustness and transparency in reporting surgical cases. They must be kept up to date in order to drive forwards reporting quality. As such, we have updated these guidelines via a DELPHI consensus exercise. METHODS: The updated guidelines were produced via a DELPHI consensus exercise. Members were invited from the previous DELPHI group, as well as editorial board members and peer reviewers of the International Journal of Surgery Case Reports. The expert group completed an online survey to indicate their agreement with proposed changes to the checklist items. RESULTS: A total of 54 surgical experts agreed to participate and 53 (98%) completed the survey. The responses and suggested modifications were incorporated into the new 2020 guideline. There was a high degree of agreement amongst the SCARE Group, with all modified SCARE items receiving over 70% scores 7-9. CONCLUSION: A DELPHI consensus exercise was completed and an updated and improved SCARE Checklist is now presented

Effect of reduced salinity on the initial mortality of Sprat, Spratelloides delicatulus (Bennett), in captivity

The effect of exposure to different concentrations of sea water on the initial mortality of Spratelloides delicatulus, the common tuna-live-bait fish of Lakshadweep, was experimented. The shock mortality of the fish due to stress of capture was found to be greatly! reduced by introducing them at once in 50% sea water. However, the aggregate mortality from the time of capture to the end of the second day was least among the fish exposed to 75% sea water, being about three-fourth of the mortality in 100% sea water