Comparison of hazard ratios of the 5 genes that were most significantly associated with metastasis based on the <i>BreastMark</i> database.

<p>Comparison of hazard ratios of the 5 genes that were most significantly associated with metastasis based on the <i>BreastMark</i> database.</p

Kaplan-Meier plots for anaesthetic and analgesic targets where high gene expression is associated with reduced time to metastasis, presented in order of significance.

<p>Samples in the <i>Breastmark</i> database were dichotomized for gene expression around a 50% median value and differences between these two populations are indicated by hazard ratios. P-values shown are those obtained by univariate analysis of the Breastmark database for the indicated gene. Adjusted p-values were calculated on the basis of adjusting for multiple testing as described in Methods. A: GRINA; B: Noradrenaline transporter; C: Mu opioid receptor; D: Delta opioid receptor; E: GABA_A receptor γ3.</p

List of 23 genes that encode for the receptor proteins that interact with the major anaesthetic and opioid analgesic receptors for which gene expression data was determined in the <i>BreastMark</i> database.

<p>List of 23 genes that encode for the receptor proteins that interact with the major anaesthetic and opioid analgesic receptors for which gene expression data was determined in the <i>BreastMark</i> database.</p

Comparison of hazard ratios of the 5 genes that were most significantly associated with metastasis based on the <i>BreastMark</i> database.

<p>Comparison of hazard ratios of the 5 genes that were most significantly associated with metastasis based on the <i>BreastMark</i> database.</p

Hazard ratios for anaesthetic and analgesic target genes based on the <i>BreastMark</i> database.

<p>Hazard ratios for anaesthetic and analgesic target genes based on the <i>BreastMark</i> database.</p

Kaplan-Meier plots for anesthetic and analgesic targets where low expression is associated with reduced time to metastasis, presented in order of significance.

<p>Samples in the <i>Breastmark</i> database were dichotomized for gene expression around a 50% median value and differences between these two populations are indicated by hazard ratios. P-values shown are those obtained by univariate analysis of the Breastmark database for the indicated gene. Adjusted p-values were calculated on the basis of adjusting for multiple testing, as described in Methods. A: Glycine beta receptor; B: GRIN3A; C: GABA_A receptor γ1; D: 5HT Transporter.</p

Survival of patients discharged to long term care

Data on the life expectancy of elderly people in long term care facilities will be important for effective service planning and monitoring quality of care. To date there are no such data from an Irish perspective. A random sample of patients discharged to long term care between Jan 1st 1997 and December 31st 2003 from a single Dublin hospital was studied. Death by January 1st 2005 was ascertained through the register of births deaths and marriage. Median survival was calculated and factors associated with mortality were determined in a logistic regression. Mean (sd) age was 82 (11) years and 61 (29%) were female. Median survival was 30.3 (95%CI 22.4-45.0) months (mean Irish life expectancy at this age is about 78 months). Three factors were independently associated with death by 2 years: age (Odds ratio 1.11 [95%CI 1.05-1.17, F ratio 15.1, p=0.0001] per year), male gender (Odds ratio 1.52 [95%CI 1.05-3.68, F ratio 5.2, p=0.024]) and discharge to continuing care (Odds ratio 1.96 [1.05-3.68, F ratio 4.4, p=0.037]). These results (which are the first such Irish data) show that patients discharged to long term care are a frail group with a reduced life expectancy. Encouragingly survival for this cohort (25% at 1 year) was similar to that seen in other countries. Data on nursing home survival will allow more accurate planning of long term residential services and help monitor quality of care