Constraining relativistic models through heavy ion collisions

Relativistic models can be successfully applied to the description of compact star properties in nuclear astrophysics as well as to nuclear matter and finite nuclei properties, these studies taking place at low and moderate temperatures. Nevertheless, all results are model dependent and so far it is unclear whether some of them should be discarded. Moreover, in the regime of hot hadronic matter very few calculations exist using these relativistic models, in particular when applied to particle yields in heavy ion collisions. In the present work we comment on the known constraints that can help the selection of adequate models in this regime and investigate the main differences that arise when the particle production during a Au+Au collision at RHIC is calculated with different models.Comment: 9 pages, 1 figure, 3 table

Early, incomplete, or preclinical autoimmune systemic rheumatic diseases and pregnancy outcome

OBJECTIVE: To evaluate the impact of preclinical systemic autoimmune rheumatic disorders on pregnancy outcome. METHODS: In this longitudinal cohort study, patients were enrolled during the first trimester of pregnancy if they reported having had connective tissue disorder symptoms, were found to be positive for circulating autoantibodies, and on clinical evaluation were judged to have a preclinical or incomplete rheumatic disorder. The incidence of fetal growth restriction (FGR), preeclampsia, and adverse pregnancy outcomes in patients with preclinical rheumatic disorders was compared with that in selected controls, after adjustment for confounders by penalized logistic regression. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. RESULTS: Of 5,232 women screened, 150 (2.9%) were initially diagnosed as having a suspected rheumatic disorder. After a mean\u2009\ub1\u2009SD postpartum follow-up of 16.7\u2009\ub1\u20095.5 months, 64 of these women (42.7%) had no clinically apparent rheumatic disease and 86 (57.3%) had persistent symptoms and positive autoantibody results, including 10 (6.7%) who developed a definitive rheumatic disease. The incidences of preeclampsia/FGR and of small for gestational age (SGA) infants were 5.1% (23 of 450) and 9.3% (42 of 450), respectively, among controls, 12.5% (8 of 640) (OR 2.7 [95% CI 1.1-6.4]) and 18.8% (12 of 64) (OR 2.2 [95% CI 1.1-4.5]), respectively, among women with no clinically apparent disease, and 16.3% (14 of 86) (OR 3.8 [95% CI 1.9-7.7]) and 18.6% (16 of 86) (OR 2.3 [95% CI 1.2-4.3]), respectively, among those with persisting symptoms at follow-up. Mean\u2009\ub1\u2009SD umbilical artery Doppler pulsatility indices were higher among women with no clinically apparent disease (0.95\u2009\ub1\u20090.2) and those with persisting symptoms (0.96\u2009\ub1\u20090.21) than in controls (0.89\u2009\ub1\u20090.12) (P\u2009=\u20090.01 and P\u2009<\u20090.001, respectively). CONCLUSION: In our study population, preclinical rheumatic disorders were associated with an increased risk of FGR/preeclampsia and SGA. The impact of these findings and their utility in screening for FGR/preeclampsia need to be confirmed in population studies

Connective tissue diseases and autoimmune thyroid disorders in the first trimester of pregnancy

OBJECTIVE: To investigate the rates and coexistence of autoimmune thyroid and connective tissue diseases (CTD) during the first trimester of pregnancy and their influence on pregnancy outcome. STUDY DESIGN: A cohort study of 150 women with CTD diagnosed during first trimester of pregnancy and 150 negative controls. MAIN OUTCOME MEASURES: Screening of CTD by a self-reported questionnaire, rheumatic and thyroid autoantibody detection, clinical rheumatological evaluation and obstetric outcomes. RESULTS: Out of 3852 women screened, 61 (1.6%) were diagnosed with undefined connective tissue disease (UCTD), 28 (0.7%) with major CTD (six rheumatoid arthritis, five systemic lupus erythematosus, eight Sjogren syndrome, five anti-phospholipid syndrome, two systemic sclerosis, one mixed CTD and one monoarticular arthritis) and 61 (1.6%) had insufficient criteria for a diagnosis of a rheumatic disease. The overall prevalence of either thyroid peroxidase (TPO-a) or thyroglobulin (TG-a) autoantibodies detection was 8% (12/150) among controls, 62.3% (38/61) among UCTD and 60.7% (17/28) in women with a major CTD (p<.001 compared to controls for both comparisons). After adjustment for confounders, overall CTDs (major or undefined) (OR=3.54, 95% CI; 1.61-7.78) and TPO-a plus TG-a positivity (OR=2.78, 95% CI;1.29-5.98) were independently associated with increased risks of moderate-severe complications of pregnancy (miscarriage, fetal growth restriction, preeclampsia, delivery before 34 weeks). CONCLUSIONS: Rheumatic and thyroid autoantibodies during pregnancy are closely associated. Thyroid antibodies could add to the risk of adverse pregnancy outcome associated with connective tissue diseases

Imprint of the symmetry energy on the inner crust and strangeness content of neutron stars

18 pages, 17 figures, submitted to EPJA, to the special issue on The Symmetry EnergyIn this work we study the effect of the symmetry energy on several properties of neutron stars. First, we discuss its effect on the density, proton fraction and pressure of the neutron star crust-core transition. We show that whereas the first two quantities present a clear correlation with the slope parameter $L$ of the symmetry energy, no satisfactory correlation is seen between the transition pressure and $L$. However, a linear combination of the slope and curvature parameters at $\rho=0.1$ fm$^{-3}$ is well correlated with the transition pressure. In the second part we analyze the effect of the symmetry energy on the pasta phase. It is shown that the size of the pasta clusters, number of nucleons and the cluster proton fraction depend on the density dependence of the symmetry energy: a small $L$ gives rise to larger clusters. The influence of the equation of state at subsaturation densities on the extension of the inner crust of the neutron star is also discussed. Finally, the effect of the effect of the density dependence of the symmetry energy on the strangeness content of neutron stars is studied in the last part of the work. It is found that charged (neutral) hyperons appear at smaller (larger) densities for smaller values of the slope parameter $L$. A linear correlation between the radius and the strangeness content of a star with a fixed mass is also found

Prevalence and significance of previously undiagnosed rheumatic diseases in pregnancy

Objectives: The objective of this study was to evaluate the rates of previously undiagnosed rheumatic diseases during the first trimester of pregnancy and their impact on the pregnancy outcome. Methods: Pregnant women in their first trimester were screened using a two-step approach using a self-administered 10-item questionnaire and subsequent testing for rheumatic autoantibodies (antinuclear antibody, anti-double-stranded DNA, anti-extractable nuclear antigen, anticardiolipin antibodies, anti-β2-glycoprotein I antibodies and lupus anticoagulant) and evaluation by a rheumatologist. Overall, the complications of pregnancy evaluated included fetal loss, pre-eclampsia, gestational diabetes, fetal growth restriction, delivery at less than 34 weeks, neonatal resuscitation and admission to the neonatal intensive care unit. Results: Out of the 2458 women screened, the authors identified 62 (2.5%) women with previously undiagnosed undifferentiated connective tissue disease (UCTD) and 24 (0.98%) women with previously undiagnosed definite systemic rheumatic disease. The prevalences were seven (0.28%) for systemic lupus erythematosus and Sjogren's syndrome, six (0.24%) for rheumatoid arthritis, three (0.12%) for antiphospholipid syndrome and one (0.04%) for systemic sclerosis. In multiple exact logistic regression, after adjustment for potential confounders, the OR of overall complications of pregnancy were 2.81 (95% CI 1.29 to 6.18) in women with UCTD and 4.57 (95% CI 1.57 to 13.57) in those with definite diseases, respectively, compared with asymptomatic controls. Conclusions: In our population approximately 2.5% and 1% of first trimester pregnant women had a previously undiagnosed UCTD and definite systemic rheumatic disease, respectively. These conditions were associated with significant negative effects on the outcome of pregnancy

Maternal and fetal Leptin and interleukin 33 concentrations in pregnancy complicated by obesity and preeclampsia

Objectives: To evaluate maternal and fetal Leptin and IL33 concentrations in pregnancy complicated by obesity and preeclampsia. Study design: A case-control study including 35 subjects with obesity (18 normotensive and 17 preeclamptic) and 47 normal weight controls (42 normotensive and 5 preeclamptic). Main outcome measures: Leptin and IL33 concentrations in maternal serum during pregnancy and in cord blood; uterine artery and umbilical artery Doppler velocimetry. Results: Subjects with obesity who developed preeclampsia had higher first trimester maternal (41.5, interquartile range (IQR) = 15.7–65.1 ng/ml) Leptin concentrations compared to either normal weight with (25, IQR = 20.4–25.8 ng/ml) and without hypertension (14.26, IQR = 8.2–22.8) (p <.05) or normotensive subjects with obesity (30.3, IQR = 10.4–38.4) (p <.05). Subjects with obesity who developed preeclampsia (2.4, IQR = 1.7–3.2 pg/ml) or not (1.4, IQR = 0.8–2 pg/ml) had lower first trimester maternal IL33 levels when compared to controls without hypertension (4.8, IQR = 2.9–5.9 pg/ml) (p <.001). Cord blood Leptin and IL33 concentrations were significantly correlated to third trimester maternal concentrations (Spearman rho = 0.51, p <.001 and Spearman rho = 0.68, p <.001, respectively). Uterine artery pulsatility index (PI) were significantly and directly correlated with maternal Leptin levels (p <.002) and inversely and statistically correlated with maternal IL33 concentrations (p <.001). Conclusions: Compared to lean controls, pregnant subjects with obesity had higher serum Leptin and lower IL33 concentrations at first trimester and during pregnancy. This difference persisted also for those who later developed preeclampsia. The relationship between maternal serum levels of Leptin and IL33 with uterine artery Doppler pulsatility index strongly suggests a role of these two markers in early placentation