Paediatric laser dentistry. Part 3: Dental trauma

Dental traumas are frequent and sometimes complex events, and at times real emergencies. There are no wellcoded guidelines for laser applications in these clinical events. Laser-assisted therapy can offer new treatment possibilities, simplify dental procedures, reduce postoperative sensitivity and the need for post-operative medications because of the laser-induced biostimulating and anti-inflammatory effects

Navigation/traffic control satellite mission study. Volume 3 - System concepts

Satellite network for air traffic control, solar flare warning, and collision avoidanc

Evaluation of biomechanical effects of interocclusal surfaces on the mandible

ABSTRACT Introduction: Only few studies in the literature employ a mathematical model in the evaluation of the stress which follows the application of loads and constraints onto the mandible. Therefore, new approaches are needed so that the study of this phenomenon can rely less on the clinical hypothesis and experience of the operator, while taking advantage of the many benefits that virtual representations and mathematical calculations present. Aim of the study is to determine, by means of the finite element method (FEM), the stress produced onto the mandible as a result of the application of a force on itself, in association or not to the perioral musculature and according to the dental support given by the positioning of an interocclusal surface at three different levels: mesial, intermediate and distal. Aim: The aim is to allow a more objective evaluation of this phenomenon, its absolute repeatability, as well as to acquire important clinical informations concerning the role of orthodontic and gnathologic appliances. Materials and methods: Starting from a 1:1 scale model of the mandible (human adult male), a virtual three - dimensional (3D) representation was first obtained thanks to a dedicate software; it was then imported into a second software in order to permit the discretization into finite elements of the virtual model and the attribution of its mechanical properties. Finally, thanks to a specific software, it was possible to simulate the presence of load and constraints and to evaluate the stress status by using pseudo - colors. Results: The stress generated following the application of a force onto the mandible, undergoes significant variations in relation to the dental support and the presence or absence of the perioral musculature. Conclusions: Following the results of our research, we consider FEM as a valid and interesting method for this purpose, however additional FEM conducted studies are necessary in order to assess this phenomenon in more detail and determine the role of the perioral musculature as well as the possible clinical implications

SAR Studies on Curcumin's Pro-inflammatory Targets: Discovery of Prenylated Pyrazolocurcuminoids as Potent and Selective Novel Inhibitors of 5-Lipoxygenase.

The anticarcinogenic and anti-inflammatory properties of curcumin have been extensively investigated, identifying prostaglandin E2 synthase (mPGES)-1 and 5-lipoxygenase (5-LO), key enzymes linking inflammation with cancer, as high affinity targets. A comparative structure-activity study revealed three modifications dissecting mPGES-1/5-LO inhibition, namely (i) truncation of the acidic, enolized dicarbonyl moiety and/or replacement by pyrazole, (ii) hydrogenation of the interaryl linker, and (iii) (dihydro)prenylation. The prenylated pyrazole analogue 11 selectively inhibited 5-LO, outperforming curcumin by a factor of up to 50, and impaired zymosan-induced mouse peritonitis along with reduced 5-LO product levels. Other pro-inflammatory targets of curcumin (i.e., mPGES-1, cyclooxygenases, 12/15-LOs, nuclear factor-κB, nuclear factor-erythroid 2-related factor-2, and signal transducer and activator of transcription 3) were hardly affected by 11. The strict structural requirements for mPGES-1 and 5-LO inhibition strongly suggest that specific interactions rather than redox or membrane effects underlie the inhibition of mPGES-1 and 5-LO by curcumin

Managing phase purities and crystal orientation for high-performance and photostable cesium lead halide perovskite solar cells

Inorganic perovskites with cesium (Cs+) as the cation have great potential as photovoltaic materials if their phase purity and stability can be addressed. Herein, a series of inorganic perovskites is studied, and it is found that the power conversion efficiency of solar cells with compositions CsPbI1.8Br1.2, CsPbI2.0Br1.0, and CsPbI2.2Br0.8 exhibits a high dependence on the initial annealing step that is found to significantly affect the crystallization and texture behavior of the final perovskite film. At its optimized annealing temperature, CsPbI1.8Br1.2 exhibits a pure orthorhombic phase and only one crystal orientation of the (110) plane. Consequently, this allows for the best efficiency of up to 14.6% and the longest operational lifetime, T S80, of ≈300 h, averaged of over six solar cells, during the maximum power point tracking measurement under continuous light illumination and nitrogen atmosphere. This work provides essential progress on the enhancement of photovoltaic performance and stability of CsPbI3 − x Brx perovskite solar cells

Perfluorinated Self Assembled Monolayers Enhance the Stability and Efficiency of Inverted Perovskite Solar Cells

Perovskite solar cells are among the most exciting photovoltaic systems as they combine low recombination losses, ease of fabrication, and high spectral tunability. The Achilles heel of this technology is the device stability due to the ionic nature of the perovskite crystal, rendering it highly hygroscopic, and the extensive diffusion of ions especially at increased temperatures. Herein, we demonstrate the application of a simple solution-processed perfluorinated self-assembled monolayer (p-SAM) that not only enhances the solar cell efficiency, but also improves the stability of the perovskite absorber and, in turn, the solar cell under increased temperature or humid conditions. The p-i-n-type perovskite devices employing these SAMs exhibited power conversion efficiencies surpassing 21%. Notably, the best performing devices are stable under standardized maximum power point operation at 85 °C in inert atmosphere (ISOS-L-2) for more than 250 h and exhibit superior humidity resilience, maintaining ∼95% device performance even if stored in humid air in ambient conditions over months (∼3000 h, ISOS-D-1). Our work, therefore, demonstrates a strategy towards efficient and stable perovskite solar cells with easily deposited functional interlayers