2,661 research outputs found
Completeness of the Bethe Ansatz solution of the open XXZ chain with nondiagonal boundary terms
A Bethe Ansatz solution of the open spin-1/2 XXZ quantum spin chain with
nondiagonal boundary terms has recently been proposed. Using a numerical
procedure developed by McCoy et al., we find significant evidence that this
solution can yield the complete set of eigenvalues for generic values of the
bulk and boundary parameters satisfying one linear relation. Moreover, our
results suggest that this solution is practical for investigating the ground
state of this model in the thermodynamic limit.Comment: 15 pages, LaTeX; amssymb, amsmath, no figures, 5 tables; v2 contains
an additional footnote and a "Note Added"; v3 contains an Addendu
Glutathione-loaded solid lipid microparticles as innovative delivery system for oral antioxidant therapy
The present study aimed to develop a novel formulation containing glutathione (GSH) as an oral antioxidant therapy for the treatment of oxidative stress-related intestinal diseases. To this purpose, solid lipid microparticles (SLMs) with Dynasan 114 and a mixture of Dynasan 114 and Dynasan 118 were produced by spray congealing technology. The obtained SLMs had main particle sizes ranging from 250 to 355 µm, suitable for oral administration. GSH was efficiently loaded into the SLMs at 5% or 20% w/w and the encapsulation process did not modify its chemico-physical properties, as demonstrated by FT-IR, DSC and HSM analysis. Moreover, in vitro release studies using biorelevant media showed that Dynasan 114-based SLMs could efficiently release GSH in various intestinal fluids, while 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay demonstrated the good radical scavenging activity of this formulation. Dynasan 114-based SLMs exhibited an excellent biocompatibility on intestinal HT-29 cells at concentrations up to 2000 µg/mL. SLMs containing GSH alone or together with another antioxidant agent (catalase) were effective in reducing intracellular reactive oxygen species (ROS) levels. Overall, this study indicated that spray congealed SLMs are a promising oral drug delivery system for the encapsulation of one or more biological antioxidant agents for local intestinal treatment
Benchmarking the Security Protocol and Data Model (SPDM) for component authentication
Efforts to secure computing systems via software traditionally focus on the
operating system and application levels. In contrast, the Security Protocol and
Data Model (SPDM) tackles firmware level security challenges, which are much
harder (if at all possible) to detect with regular protection software. SPDM
includes key features like enabling peripheral authentication, authenticated
hardware measurements retrieval, and secure session establishment. Since SPDM
is a relatively recent proposal, there is a lack of studies evaluating its
performance impact on real-world applications. In this article, we address this
gap by: (1) implementing the protocol on a simple virtual device, and then
investigating the overhead introduced by each SDPM message; and (2) creating an
SPDM-capable virtual hard drive based on VirtIO, and comparing the resulting
read/write performance with a regular, unsecured implementation. Our results
suggest that SPDM bootstrap time takes the order of tens of milliseconds, while
the toll of introducing SPDM on hard drive communication highly depends on
specific workload patterns. For example, for mixed random read/write
operations, the slowdown is negligible in comparison to the baseline unsecured
setup. Conversely, for sequential read or write operations, the data encryption
process becomes the bottleneck, reducing the performance indicators by several
orders of magnitude.Comment: 10 pages, 8 figure
Detection and Quantification of Grass and Olea Airborne Pollen Allergens in Outdoor Air Samples and its Correlation with Pollen Counts
Detection and Quantification of Grass and Olea Airborne Pollen Allergens in Outdoor Air Samples and its Correlation with Pollen Counts
R Ferro1*, R Ribeiro1*, MR Martins1,2, AT Caldeira1,3, E Caeiro6, CM Antunes1,5
& R BrandĂŁo2,4 and the HIALINE working group7
1Dep. of Chemistry, University of Evora, Portugal;
2Mediterranean Inst. Crop and Environment Sciences, Univ.Evora, Portugal;
3Centro QuĂmica, University of Évora, Portugal;
4Dep. Biology, University of Evora;
5Center for NeuroSciences and Cell Biology-University of Coimbra, Portugal;
6Soc.Portuguesa Alergol.Imunologia ClĂnica , Portugal
7 M. Thibaudon, France, M. Smith, United Kingdom, C. Galan, Spain R. Albertini, Italy, L. Grewling, Poland, G. Reese, Germany, A. Rantio-Lehtimäki, Finland, S. Jäger and U. Berger, Austria, M. Sofiev, Finland, I. Sauliene, Lithuania, L. Cecchi, Italy
Presenting author: [email protected] tel: +351 266760889
Introduction: Allergic respiratory diseases broken out after an exposure to airborne pollen, as asthma and allergic rhinitis, are deeply increasing and they represent one of the major public health problems nowadays, affecting about 40% of European population. In Portugal, grass and Olea europaea pollen are certainly one of the main sources of athmospheric aeroallergens and as such, one of the main causes of respiratory allergy.
For these reasons, it is useful the development of new strategies for prevention and treatment of these pathologies. The execution of aerobiological analysis including pollen calendars and/or immunoassays for the detection and quantification of allergens which could forecast the allergenic potential of the athmosphere are quite relevant since they would contribute to develop prevention measures of allergic respiratory diseases. The aim of this study was to evaluate the putative correlation between the concentration of some of the major allergens of and with their pollen counts.
Methodology: On a meteorological platform at the town center of Evora (south Portugal), ambient air was sampled at 800L/min with a Chemvol high-volume cascade impactor equipped with stages PM>10µm, 10 µm>PM>2.5µm. The polyurethane impacting substrate was extracted with 0.1M NH4HCO3, pH8.1, supplemented with 0.1% BSA. The major pollen allergens from grass Phleum p 5 and olive Ole e 1 were determined with allergen specific ELISA´s. Airborne pollen of and Olea europaea simultaneously monitored with a Burkard Seven Day Recording Volumetric Spore Trap* , between the 30th of April and the 8th of July of 2009. Both samplers were placed side-by-side with air input at the same level.
Results: During the pollen season of 2009, high values of grass pollen were recorded between May 2th and June 1 th. It was also observed that the air content of Phl p5 or Ole e1 aeroallergens were directly correlated with airborne pollen counts of Poaceae and Oleaceae, respectively.
Conclusions: These results suggest that the directly quantification of aeroallergens may contribute, together with pollen counts of air samples, to define the allergic risk with higher precision.
Acknowledgments: This study is integrated in the european project HIALINE (Executive Agency for Health and Consumers under grant agreement No 2008 11 07
Nonequilibrium Forces Between Neutral Atoms Mediated by a Quantum Field
We study all known and as yet unknown forces between two neutral atoms,
modeled as three dimensional harmonic oscillators, arising from mutual
influences mediated by an electromagnetic field but not from their direct
interactions. We allow as dynamical variables the center of mass motion of the
atom, its internal degrees of freedom and the quantum field treated
relativistically. We adopt the method of nonequilibrium quantum field theory
which can provide a first principle, systematic and unified description
including the intrinsic field fluctuations and induced dipole fluctuations. The
inclusion of self-consistent back-actions makes possible a fully dynamical
description of these forces valid for general atom motion. In thermal
equilibrium we recover the known forces -- London, van der Waals and
Casimir-Polder forces -- between neutral atoms in the long-time limit but also
discover the existence of two new types of interatomic forces. The first, a
`nonequilibrium force', arises when the field and atoms are not in thermal
equilibrium, and the second, which we call an `entanglement force', originates
from the correlations of the internal degrees of freedom of entangled atoms.Comment: 16 pages, 2 figure
Analyticity and Integrabiity in the Chiral Potts Model
We study the perturbation theory for the general non-integrable chiral Potts
model depending on two chiral angles and a strength parameter and show how the
analyticity of the ground state energy and correlation functions dramatically
increases when the angles and the strength parameter satisfy the integrability
condition. We further specialize to the superintegrable case and verify that a
sum rule is obeyed.Comment: 31 pages in harvmac including 9 tables, several misprints eliminate
Thermodynamics of the 3-State Potts Spin Chain
We demonstrate the relation of the infrared anomaly of conformal field theory
with entropy considerations of finite temperature thermodynamics for the
3-state Potts chain. We compute the free energy and compute the low temperature
specific heat for both the ferromagnetic and anti-ferromagnetic spin chains,
and find the central charges for both.Comment: 18 pages, LaTex. Preprint # ITP-SB-92-60. References added and first
section expande
model as effective Hamiltonian for generalized Hubbard models with broken -symmetry
We consider the limit of strong Coulomb attraction for generalized Hubbard
models with -symmetry. In this limit these models are equivalent to the
ferromagnetic spin-1/2 Heisenberg quantum spin chain. In order to study the
behaviour of the superconducting phase in the electronic model under
perturbations which break the -symmetry we investigate the ground state
of the ferromagnetic non-critical -chain in the sector with fixed
magnetization. It turns out to be a large bound state of magnons. We find
that the perturbations considered here lead to the disappearance of the
off-diagonal longe-range order.Comment: Results of previous version are generalized, new title, references
added. 10 pages, Latex, no figure
Two dimensionale plastic waves in quasi rate independent viscoplastic materials
The subject of this work is an analysis of the experimental biaxial Hopkinson bar technique when such a device consists of a cruciform tensile specimen surrounded by four very long elastic bars. Unlike commonly applied by-pass analysis which attempts to draw conclusions from behavior of elastic bars we attempt to take into account real plastic waves inside the specimen with few hundreds of reflections. A quasi rate-independent as well as a more general rate-dependent tensor function model for ASME 537 steel are applied. Plastic wave speeds non-existent in traditional elasto-viscoplasticity are analyzed. Some preliminary numerical results for symmetric and non-symmetric loading cases valid for initial and subsequent elastic ranges are given
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