Pregnancy in a Woman with Homozygous Familial Hypercholesterolemia Not on Low-Density Lipoprotein Apheresis

Pregnancy in women with homozygous familial hypercholesterolemia (FH) has been rarely reported and might pose risks on the mother and her fetus. Although most reported cases remained on low-density lipoprotein (LDL) apheresis, there are no clear guidelines regarding the management of this entity. We report the first case of an uncomplicated pregnancy in a 24-year-old homozygous FH woman who was not maintained on LDL apheresis. FH expresses a wide variability in the phenotype, and management of homozygous FH cases who desire to become pregnant should be individualized based on preconceptional assessment with frequent antenatal follow-up. Decisions on management should be made after weighing the risks versus benefits of LDL apheresis

The Chinese "Oppression" remedy: Creative interpretations of company law by Chinese courts

This is the first detailed study of the Chinese oppression remedy under the PRC Company Law (article 20.1-2). Compared to its U.K., Canadian, and Australian equivalents, the wording of the Chinese remedy is vague, and the Supreme People's Court has not clarified its meaning. Legal scholars have virtually ignored this remedy due to its vagueness and apparent unenforceability, and the Supreme People's Court has not produced any authoritative interpretations to clarify its meaning. Yet Chinese courts have acted pragmatically, building up a body of de facto case precedents to transform this remedy into an effective tool for minority shareholders, both Chinese and foreign (and in some cases companies too), to obtain redress for a broad range of wrongs committed by abusive shareholders. At the same time, the vagueness of the statute has led courts to draw differing conclusions over issues such as who is a proper plaintiff; how the oppression remedy relates to the derivative action; and how the term "shareholder" should be defined. These differences need to be addressed by the Supreme People's Court or by legislative amendment to avoid further inconsistent outcomes for parties involved in intra-corporate disputes in China. Alternatively, the use of case precedents based on online judgment databases should be formalized in China to bring more predictability to statutory interpretation and more consistency among courts throughout the country

Predicting wins, losses and attributes' sensitivities in the soccer World Cup 2018 using neural network analysis

Predicting the results of soccer competitions and the contributions of match attributes, in particular, has gained popularity in recent years. Big data processing obtained from different sensors, cameras and analysis systems needs modern tools that can provide a deep understanding of the relationship between this huge amount of data produced by sensors and cameras, both linear and non-linear data. Using data mining tools does not appear sufficient to provide a deep understanding of the relationship between the match attributes and results and how to predict or optimize the results based upon performance variables. This study aimed to suggest a different approach to predict wins, losses and attributes' sensitivities which enables the prediction of match results based on the most sensitive attributes that affect it as a second step. A radial basis function neural network model has successfully weighted the effectiveness of all match attributes and classified the team results into the target groups as a win or loss. The neural network model's output demonstrated a correct percentage of win and loss of 83.3% and 72.7% respectively, with a low Root Mean Square training error of 2.9% and testing error of 0.37%. Out of 75 match attributes, 19 were identified as powerful predictors of success. The most powerful respectively were: the Total Team Medium Pass Attempted (MBA) 100%; the Distance Covered Team Average in zone 3 (15-20 km/h; Zone3_TA) 99%; the Team Average ball delivery into the attacking third of the field (TA_DAT) 80.9%; the Total Team Covered Distance without Ball Possession (Not in_Poss_TT) 76.8%; and the Average Distance Covered by Team (Game TA) 75.1%. Therefore, the novel radial based function neural network model can be employed by sports scientists to adapt training, tactics and opposition analysis to improve performance

Connecting the Lines between Hypogonadism and Atherosclerosis

Epidemiological studies show that atherosclerotic cardiovascular disease is a leading cause of morbidity and mortality worldwide and point to gender differences with ageing males being at highest risk. Atherosclerosis is a complex process that has several risk factors and mediators. Hypogonadism is a commonly undiagnosed disease that has been associated with many of the events, and risk factors leading to atherosclerosis. The mechanistic relations between testosterone levels, atherosclerotic events, and risk factors are poorly understood in many instances, but the links are clear. In this paper, we summarize the research journey that explains the link between hypogonadism, each of the atherosclerotic events, and risk factors. We look into the different areas from which lessons could be learned, including epidemiological studies, animal and laboratory experiments, studies on androgen deprivation therapy patients, and studies on testosterone-treated patients. We finish by providing recommendations for the clinician and needs for future research

Pim1 is upregulated by hypoxia in hepatocellular carcinoma and promotes tumor progression

Poster Session - Molecular pathogenesis, molecular pathology, cell biology and translational research: no. P-022INTRODUCTION: Hepatocellular carcinoma (HCC) is the second/third most common fatal cancer in Hong Kong and Southeast Asia associated with frequent tumor recurrence and metastasis. Apart from surgical intervention, tumor control at cellular and molecular levels can possibly improve clinical outcome. HCC is characteristically one of the most rapidly proliferating tumors which often outpace functional blood supply, leading to a regional oxygen deprivation. Therefore, molecular changes induced by hypoxia are attractive therapeutic targets. Overexpression of PIM1, a serine/threonine kinase, has been identified in recent years in solid cancers such as prostate cancer, gastric cancer, and pancreatic cancer. In the latter, PIM1 was upregulated by hypoxia. In this study, we aim at investigating the expression, functional role, and regulatory mechanism of PIM1 in HCC, which have …published_or_final_versio

Review: revisiting the human cholinergic nucleus of the diagonal band of Broca

Although the nucleus of the vertical limb of the diagonal band of Broca (nvlDBB) is the second largest cholinergic nucleus in the basal forebrain, after the nucleus basalis of Meynert (nbM), it has not generally been a focus for studies of neurodegenerative disorders. However, the nvlDBB does have an important projection to the hippocampus and discrete lesions of the rostral basal forebrain have been shown to disrupt retrieval memory function, a major deficit seen in patients with Lewy body disorders. One reason for its neglect is that the anatomical boundaries of the nvlDBB are ill defined and this area of the brain is not part of routine diagnostic sampling protocols. We have reviewed the history and anatomy of the nvlDBB and now propose guidelines for distinguishing nvlDBB from other neighbouring cholinergic cell groups for standardising future clinicopathological work. Thorough review of the literature regarding neurodegenerative conditions reveals inconsistent results in terms of cholinergic neuronal loss within the nvlDBB. This is likely to be due to the use of variable neuronal inclusion criteria and omission of cholinergic immunohistochemical markers. Extrapolating from those studies showing significant nvlDBB neuronal loss in Lewy body dementia, we propose an anatomical and functional connection between the cholinergic component of the nvlDBB (Ch2) and the CA2 subfield in the hippocampus which may be especially vulnerable in Lewy body disorders. This article is protected by copyright. All rights reserved

Diet, Genetics, and Disease: A Focus on the Middle East and North Africa Region

The Middle East and North Africa (MENA) region suffers a drastic change from a traditional diet to an industrialized diet. This has led to an unparalleled increase in the prevalence of chronic diseases. This review discusses the role of nutritional genomics, or the dietary signature, in these dietary and disease changes in the MENA. The diet-genetics-disease relation is discussed in detail. Selected disease categories in the MENA are discussed starting with a review of their epidemiology in the different MENA countries, followed by an examination of the known genetic factors that have been reported in the disease discussed, whether inside or outside the MENA. Several diet-genetics-disease relationships in the MENA may be contributing to the increased prevalence of civilization disorders of metabolism and micronutrient deficiencies. Future research in the field of nutritional genomics in the MENA is needed to better define these relationships

Signature Activation: A Sparse Signal View for Holistic Saliency

The adoption of machine learning in healthcare calls for model transparency and explainability. In this work, we introduce Signature Activation, a saliency method that generates holistic and class-agnostic explanations for Convolutional Neural Network (CNN) outputs. Our method exploits the fact that certain kinds of medical images, such as angiograms, have clear foreground and background objects. We give theoretical explanation to justify our methods. We show the potential use of our method in clinical settings through evaluating its efficacy for aiding the detection of lesions in coronary angiograms