Where do uncertainties reside within environmental risk assessments? Expert opinion on uncertainty distributions for pesticide risks to surface water organisms

A reliable characterisation of uncertainties can aid uncertainty identification during environmental risk assessments (ERAs). However, typologies can be implemented inconsistently, causing uncertainties to go unidentified. We present an approach based on nine structured elicitations, in which subject-matter experts, for pesticide risks to surface water organisms, validate and assess three dimensions of uncertainty: its level (the severity of uncertainty, ranging from determinism to ignorance); nature (whether the uncertainty is epistemic or aleatory); and location (the data source or area in which the uncertainty arises). Risk characterisation contains the highest median levels of uncertainty, associated with estimating, aggregating and evaluating the magnitude of risks. Regarding the locations in which uncertainty is manifest, data uncertainty is dominant in problem formulation, exposure assessment and effects assessment. The comprehensive description of uncertainty described will enable risk analysts to prioritise the required phases, groups of tasks, or individual tasks within a risk analysis according to the highest levels of uncertainty, the potential for uncertainty to be reduced or quantified, or the types of location-based uncertainty, thus aiding uncertainty prioritisation during environmental risk assessments. In turn, it is expected to inform investment in uncertainty reduction or targeted risk management action

everything is at once: Reflections on embodied photography and collaborative process

In discussion with his co-collaborators, dance artists Natalie Garrett Brown and Amy Voris, this interview explores the photographic process of Christian Kipp, landscape and dance photographer, as he reflects on his experience of working on the Enter & Inhabit project. The questions asked by Garrett Brown and Voris were generated through movement and reflective writing in response to the photographic collection exhibited as part of the 2011 Dance and Somatic Practices Conference, Coventry, UK. In particular, the article explores the interrelationship between the somatic-informed movement practices and performance score creation of Garrett Brown and Voris and the sensorial play of Kipp’s photography. Co-authored by Garrett Brown, Kipp and Voris, this collection of questions and responses seeks to continue rather than merely document the Enter & Inhabit collaborative process

MOBILE and the provision of total joint replacement

Modern joint replacements have been available for 45 years, but we still do not have clear indications for these interventions, and we do not know how to optimize the outcome for patients who agree to have them done. The MOBILE programme has been investigating these issues in relation to primary total hip and knee joint replacements, using mixed methods research

From treebank resources to LFG F-structures

We present two methods for automatically annotating treebank resources with functional structures. Both methods define systematic patterns of correspondence between partial PS configurations and functional structures. These are applied to PS rules extracted from treebanks, or directly to constraint set encodings of treebank PS trees

Response to comment on "solid recovered fuel: Materials flow analysis and fuel property development during the mechanical processing of biodried waste"

Laner and Cencic1 comment on Velis et al. (2013)2 clarifying certain points on the use of the material flow analysis (MFA) software STAN3. We welcome the correspondence and the opportunity this exchange provides to discuss optimal approaches to using STAN. In keeping with Velis et al.2 these physically impossible, and otherwise insignificant, negative flows have enabled improvements to STAN. Here, we elaborate on the practicalities of using STAN in our research and on the correctness and validation of our results, notwithstanding the inclusion of negative flows. We explain the contribution of our approach to solid waste management and resource recovery

Biochemical and clinical response after umbilical cord blood transplant in a boy with early childhood-onset beta-mannosidosis.

BACKGROUND: Deficiency in the enzyme β-mannosidase was described over three decades ago. Although rare in occurrence, the presentation of childhood-onset β-mannosidase deficiency consists of hypotonia in the newborn period followed by global development delay, behavior problems, and intellectual disability. No effective pharmacologic treatments have been available. METHODS: We report 2-year outcomes following the first umbilical cord blood transplant in a 4-year-old boy with early childhood-onset disease. RESULTS: We show restoration of leukocyte β-mannosidase activity which remained normal at 2 years posttransplant, and a simultaneous increase in plasma β-mannosidase activity and dramatic decrease in urine-free oligosaccharides were also observed. MRI of the brain remained stable. Neurocognitive evaluation revealed test point gains, although the magnitude of improvement was less than expected for age, causing lower IQ scores that represent a wider developmental gap between the patient and unaffected peers. CONCLUSION: Our findings suggest that hematopoietic cell transplant can correct the biochemical defect in β-mannosidosis, although preservation of the neurocognitive trajectory may be a challenge

Neurospora strains incorporating fluffy, and their use as testers.

We have used fluffy (fl) strains extensively as female parents in mating-type tests and for a variety of other applications where high fertility and absence of conidia are advantageous

Fault and magmatic interaction within Iceland's western rift over the last 9kyr

We present high-resolution 'Chirp' sub-bottom profiler data from Thingvallavatn, a lake in Iceland's western rift zone. These data are combined with stratigraphic constraints from sediment cores to show that movement on normal faults since 9 ka are temporally correlated with magmatic events, indicating that movements were controlled by episodic dyke intrusion. Sediment depo-centres and the focus of subsidence migrated westwards over 3-4 kyr towards the locus of subsequent brittle failure. We interpret this subsidence as related to dyke intrusion a few km along strike, originating from the Hengill volcanic system, which occurred prior to major dyking, faulting and subsidence within the lake at 1.9 ka

Better by design: Rethinking interventions for better environmental regulation

etter regulation seeks to extend existing policy and regulatory outcomes at less burden for the actors involved. No single intervention will deliver all environmental outcomes. There is a paucity of evidence on what works why, when and with whom. We examine how a sample (n=33) of policy makers select policy and regulatory instruments, through a case study of the Department for Environment, Food and Rural Affairs (Defra), UK. Policy makers have a wide range of instruments at their disposal and are seeking ways to harness the influence of non-governmental resources to encourage good environmental behaviour. The relevance of each influence varies as risk and industry characteristics vary between policy areas. A recent typology of policy and regulatory instruments has been refined. Direct regulation is considered necessary in many areas, to reduce environmental risks with confidence and to tackle poor environmental performance. Co-regulatory approaches may provide important advantages to help accommodate uncertainty for emerging policy problems, providing a mechanism to develop trusted evidence and to refine objectives as problems are better understood