22 research outputs found
Full-Stokes polarimetry with circularly polarized feeds - Sources with stable linear and circular polarization in the GHz regime
We present a pipeline that allows recovering reliable information for all
four Stokes parameters with high accuracy. Its novelty relies on the treatment
of the instrumental effects already prior to the computation of the Stokes
parameters contrary to conventional methods, such as the M\"uller matrix one.
The instrumental linear polarization is corrected across the whole telescope
beam and significant Stokes and can be recovered even when the recorded
signals are severely corrupted. The accuracy we reach in terms of polarization
degree is of the order of 0.1-0.2 %. The polarization angles are determined
with an accuracy of almost 1. The presented methodology was applied
to recover the linear and circular polarization of around 150 Active Galactic
Nuclei. The sources were monitored from July 2010 to April 2016 with the
Effelsberg 100-m telescope at 4.85 GHz and 8.35 GHz with a cadence of around
1.2 months. The polarized emission of the Moon was used to calibrate the
polarization angle. Our analysis showed a small system-induced rotation of
about 1 at both observing frequencies. Finally, we identify five
sources with significant and stable linear polarization; three sources remain
constantly linearly unpolarized over the period we examined; a total of 11
sources have stable circular polarization degree and four of
them with non-zero . We also identify eight sources that maintain
a stable polarization angle over the examined period. All this is provided to
the community for polarization observations reference. We finally show that our
analysis method is conceptually different from the traditionally used ones and
performs better than the M\"uller matrix method. Although it was developed for
a system equipped with circularly polarized feeds it can easily be modified for
systems with linearly polarized feeds as well.Comment: 19 pages, 17 figures, accepted for publication in Astronomy &
Astrophysics on May 30, 201
Novel curcumin- and emodin-related compounds identified by in silico 2D/3D conformer screening induce apoptosis in tumor cells
BACKGROUND: Inhibition of the COP9 signalosome (CSN) associated kinases CK2 and PKD by curcumin causes stabilization of the tumor suppressor p53. It has been shown that curcumin induces tumor cell death and apoptosis. Curcumin and emodin block the CSN-directed c-Jun signaling pathway, which results in diminished c-Jun steady state levels in HeLa cells. The aim of this work was to search for new CSN kinase inhibitors analogue to curcumin and emodin by means of an in silico screening method. METHODS: Here we present a novel method to identify efficient inhibitors of CSN-associated kinases. Using curcumin and emodin as lead structures an in silico screening with our in-house database containing more than 10(6 )structures was carried out. Thirty-five compounds were identified and further evaluated by the Lipinski's rule-of-five. Two groups of compounds can be clearly discriminated according to their structures: the curcumin-group and the emodin-group. The compounds were evaluated in in vitro kinase assays and in cell culture experiments. RESULTS: The data revealed 3 compounds of the curcumin-group (e.g. piceatannol) and 4 of the emodin-group (e.g. anthrachinone) as potent inhibitors of CSN-associated kinases. Identified agents increased p53 levels and induced apoptosis in tumor cells as determined by annexin V-FITC binding, DNA fragmentation and caspase activity assays. CONCLUSION: Our data demonstrate that the new in silico screening method is highly efficient for identifying potential anti-tumor drugs