17,018 research outputs found

    Lone Higgs at the LHC

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    We address the possible scenario that the Large Hadron Collider (LHC) discovers only a Higgs boson after 10 fb^{-1} of operation, and attempt to identify this Higgs boson as that of the Standard Model (SM), the minimal universal extra dimension model (MUED), the littlest Higgs model with T-parity (LHT), or the minimal supersymmetric Standard Model (MSSM), using only the measurement of the product of gluon-fusion production cross section and the di-photon branching ratio. In MUED, by decoupling any new physics sufficiently to evade the discovery reach at the LHC, the deviation of the signal from the SM is not statistically significant. However, in LHT and MSSM, it is possible to have a significant deviation in the signal that is consistent with this "lone Higgs scenario", and, in the case of a very large suppression, we can distinguish MSSM and LHT before the discovery of any new resonances. Starting with the lone Higgs scenario and the deviation in this measurement from the Standard Model prediction (whether or not statistically significant), we offer tests that may discriminate the models and search strategies of discovering new physics signatures with increasing integrated luminosity.Comment: 32 pages, 25 figures, PRD versio

    Insights into antibody catalysis: Structure of an oxygenation catalyst at 1.9-Å resolution

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    The x-ray crystal structures of the sulfide oxidase antibody 28B4 and of antibody 28B4 complexed with hapten have been solved at 2.2-Å and 1.9-Å resolution, respectively. To our knowledge, these structures are the highest resolution catalytic antibody structures to date and provide insight into the molecular mechanism of this antibody-catalyzed monooxygenation reaction. Specifically, the data suggest that entropic restriction plays a fundamental role in catalysis through the precise alignment of the thioether substrate and oxidant. The antibody active site also stabilizes developing charge on both sulfur and periodate in the transition state via cation-pi and electrostatic interactions, respectively. In addition to demonstrating that the active site of antibody 28B4 does indeed reflect the mechanistic information programmed in the aminophosphonic acid hapten, these high-resolution structures provide a basis for enhancing turnover rates through mutagenesis and improved hapten design

    Evaluation of aerothermal modeling computer programs

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    Various computer programs based upon the SIMPLE or SIMPLER algorithm were studied and compared for numerical accuracy, efficiency, and grid dependency. Four two-dimensional and one three-dimensional code originally developed by a number of research groups were considered. In general, the accuracy and computational efficieny of these TEACH type programs were improved by modifying the differencing schemes and their solvers. A brief description of each program is given. Error reduction, spline flux and second upwind differencing programs are covered
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