Galactic fountains and outflows in star forming dwarf galaxies: ISM expulsion and chemical enrichment

We investigated the impact of supernova feedback in gas-rich dwarf galaxies experiencing a low-to-moderate star formation rate, typical of relatively quiescent phases between starbursts. We calculated the long term evolution of the ISM and the metal-rich SN ejecta using 3D hydrodynamic simulations, in which the feedback energy is deposited by SNeII exploding in distinct OB associations. We found that a circulation flow similar to galactic fountains is generally established, with some ISM lifted at heights of one to few kpc above the galactic plane. This gas forms an extra-planar layer, which falls back to the plane in about $10^8$ yr, once the star formation stops. Very little or no ISM is expelled outside the galaxy system for the considered SFRs, even though in the most powerful model the SN energy is comparable to the gas binding energy. The metal-rich SN ejecta is instead more vulnerable to the feedback and we found that a significant fraction (25-80\%) is vented in the intergalactic medium, even for low SN rate ($7\times 10^{-5}$ - $7\times 10^{-4}$ yr$^{-1}$). About half of the metals retained by the galaxy are located far ($z >$ 500 pc) from the galactic plane. Moreover, our models indicate that the circulation of the metal-rich gas out from and back to the galactic disk is not able to erase the chemical gradients imprinted by the (centrally concentrated) SN explosions.Comment: 19 pages, MNRAS accepte

Feedback from massive stars and gas expulsion from proto-globular clusters

© 2015. The American Astronomical Society. All rights reserved. Globular clusters (GCs) are considerably more complex structures than previously thought, harboring at least two stellar generations that present clearly distinct chemical abundances. Scenarios explaining the abundance patterns in GCs mostly assume that originally the clusters had to be much more massive than today, and that the second generation of stars originates from the gas shed by stars of the first generation (FG). The lack of metallicity spread in most GCs further requires that the supernova-enriched gas ejected by the FG is completely lost within ∼30 Myr, a hypothesis never tested by means of three-dimensional hydrodynamic simulations. In this paper, we use 3D hydrodynamic simulations including stellar feedback from winds and supernovae, radiative cooling and self-gravity to study whether a realistic distribution of OB associations in a massive proto-GC of initial mass M tot ∼ 10 7 M o is sufficient to expel its entire gas content. Our numerical experiment shows that the coherence of different associations plays a fundamental role: as the bubbles interact, distort, and merge, they carve narrow tunnels that reach deeper and deeper toward the innermost cluster regions, and through which the gas is able to escape. Our results indicate that after 3 Myr, the feedback from stellar winds is responsible for the removal of ∼40% of the pristine gas, and that after 14 Myr, 99% of the initial gas mass has been removed

Colour gradients of high-redshift Early-Type Galaxies from hydrodynamical monolithic models

We analyze the evolution of colour gradients predicted by the hydrodynamical models of early type galaxies (ETGs) in Pipino et al. (2008), which reproduce fairly well the chemical abundance pattern and the metallicity gradients of local ETGs. We convert the star formation (SF) and metal content into colours by means of stellar population synthetic model and investigate the role of different physical ingredients, as the initial gas distribution and content, and eps_SF, i.e. the normalization of SF rate. From the comparison with high redshift data, a full agreement with optical rest-frame observations at z < 1 is found, for models with low eps_SF, whereas some discrepancies emerge at 1 < z < 2, despite our models reproduce quite well the data scatter at these redshifts. To reconcile the prediction of these high eps_SF systems with the shallower colour gradients observed at lower z we suggest intervention of 1-2 dry mergers. We suggest that future studies should explore the impact of wet galaxy mergings, interactions with environment, dust content and a variation of the Initial Mass Function from the galactic centers to the peripheries.Comment: 13 pages, 7 figures, 1 table, accepted for publication on MNRA

3D Numerical Simulations of AGN Outflows in Clusters and Groups

We compute 3D gasdynamical models of jet outflows from the central AGN, that carry mass as well as energy to the hot gas in galaxy clusters and groups. These flows have many attractive attributes for solving the cooling flow problem: why the hot gas temperature and density profiles resemble cooling flows but show no spectral evidence of cooling to low temperatures. Subrelativistic jets, described by a few parameters, are assumed to be activated when gas flows toward or cools near a central SMBH. Using approximate models for a rich cluster (A1795), a poor cluster (2A 0336+096) and a group (NGC 5044), we show that mass-carrying jets with intermediate mechanical efficiencies ($\sim10^{-3}$) can reduce for many Gyr the global cooling rate to or below the low values implied by X-spectra, while maintaining $T$ and $\rho$ profiles similar to those observed, at least in clusters. Groups are much more sensitive to AGN heating and present extreme time variability in both profiles. Finally, the intermittency of the feedback generates multiple generations of X-ray cavities similar to those observed in Perseus cluster and elsewhere. Thus we also study the formation of buoyant bubbles and weak shocks in the ICM, along with the injection of metals by SNIa and stellar winds.Comment: 4 pages, 2 figures, to appear in proceedings of the conference "The Monster's Fiery Breath: Feedback in Galaxies, Groups, and Clusters", June 2009, Madison Wisconsi

Decoupled and inhomogeneous gas flows in S0 galaxies

A recent analysis of the "Einstein" sample of early-type galaxies has revealed that at any fixed optical luminosity Lb S0 galaxies have lower mean X-ray luminosity Lx per unit Lb than ellipticals. Following a previous analytical investigation of this problem (Ciotti & Pellegrini 1996), we have performed 2D numerical simulations of the gas flows inside S0 galaxies in order to ascertain the effectiveness of rotation and/or galaxy flattening in reducing the Lx/Lb ratio. The flow in models without SNIa heating is considerably ordered, and essentially all the gas lost by the stars is cooled and accumulated in the galaxy center. If rotation is present, the cold material settles in a disk on the galactic equatorial plane. Models with a time decreasing SNIa heating host gas flows that can be much more complex. After an initial wind phase, gas flows in energetically strongly bound galaxies tend to reverse to inflows. This occurs in the polar regions, while the disk is still in the outflow phase. In this phase of strong decoupling, cold filaments are created at the interface between inflowing and outflowing gas. Models with more realistic values of the dynamical quantities are preferentially found in the wind phase with respect to their spherical counterparts of equal Lb. The resulting Lx of this class of models is lower than in spherical models with the same Lb and SNIa heating. At variance with cooling flow models, rotation is shown to have only a marginal effect in this reduction, while the flattening is one of the driving parameters for such underluminosity, in accordance with the analytical investigation.Comment: 32 pages LaTex file, plus 5 .ps figures and macro aasms4.sty -- Accepted on Ap

Biological Applications of Synthetic Binders Isolated from a Conceptually New Adhiron Library

Background: Adhirons are small (10 kDa) synthetic ligands that might represent an alternative to antibody fragments and to alternative scaffolds such as DARPins or affibodies. Methods: We prepared a conceptionally new adhiron phage display library that allows the presence of cysteines in the hypervariable loops and successfully panned it against antigens possessing different characteristics. Results: We recovered binders specific for membrane epitopes of plant cells by panning the library directly against pea protoplasts and against soluble C-Reactive Protein and SpyCatcher, a small protein domain for which we failed to isolate binders using pre-immune nanobody libraries. The best binders had a binding constant in the low nM range, were produced easily in bacteria (average yields of 15 mg/L of culture) in combination with different tags, were stable, and had minimal aggregation propensity, independent of the presence or absence of cysteine residues in their loops. Discussion: The isolated adhirons were significantly stronger than those isolated previously from other libraries and as good as nanobodies recovered from a naïve library of comparable theoretical diversity. Moreover, they proved to be suitable reagents for ELISA, flow cytometry, the western blot, and also as capture elements in electrochemical biosensors

Analysis of different genetics traits and their association with biofilm formation in Staphylococcus epidermidis isolates from central venous catheter infections

The aim of the present study was to characterize clinical isolates of Staphylococcus epidermidis, one of the bacterial species most often implicated in foreign-body-associated infections, for their ability to form biofilms and for the presence of mecA and IS256 element. Sixty-seven Staphylococcus epidermidis clinical isolates, obtained from implantable medical devices, were investigated. Overall, 70% of the strains were positive for ica operon genes, 85% possessed atlE, and 46% contained aap. In 89% of the population, the Congo red agar test confirmed the correlation between the presence of ica genes and slime expression. Almost all of the strains could be classified as biofilm producers by both the crystal violet assay and microscopy. The bacterial population studied showed a very high frequency of strains positive for mecA as well as for the IS256 element. Although well-structured biofilms have been previously observed only in those strains possessing genes belonging to the ica operon, this study demonstrates that strains lacking specific biofilm-formation determinants can be isolated from catheters and can form a biofilm in vitro. Hence, different and yet-to-be identified factors may work together in the formation and organization of complex staphylococcal microbial communities and sustain infections associated with implanted medical devices

Perception of nurses’ professional identity during the first wave of COVID-19 pandemic infections

Background and aim of the work: The main purpose of this study is to investigate on the experience of nurses working in the Covid-19 area focusing on their role’s perception. In particular, we explored the nurses’ perception of job satisfaction in relation to the images sent back by public opinion through the mass media and social communication channels. During the first wave of Covid-19 nurses have acquired media visibility, but their feeling is represented more by the discomfort of finding themselves suddenly glorified in the face of a lack of professional, social, and economic recognition. Materials and methods: A Mix-Method methodology and convenience sampling was adopted, on the population of professionals and students in post-graduate specializations, belonging to the Department of Medicine and Surgery of the University of Parma, and by nurses from the ASST-Bergamo Est, Lombardia Italy, who worked in the Covid emergency during the first wave of the pandemic, from February 2020 to May 2020. In the quantitative phase Stamm’s Professional Quality of Life Scale - ProQOL was administered to 89 respondents through a Google Form, In the qualitative phase, 3 Focus Groups were conducted on a total of 17 students. Results: At the ProQOL questionnaire, a moderate score was found in the Compassion Satisfaction scale (CF = 38.28) and in the Secondary Traumatic Stress subscale (STS-24.33), while low values emerged in the Burnout subscale (BO = 16.02). Five specific topics emerged from the focus groups: Professional collaboration, Job satisfaction, Nurse’s personal skills, Failure to protect the public image and the nursing profession. Conclusions: The professional collaboration, union with the work team, sense of solidarity, job satisfaction, professional growth, and awareness of one’s role seem to have worked favorably on Compassion Satisfaction, while keeping Compassion Fatigue levels under control

Neck paraganglioma and follicular lymphoma: A case report

Background: Paragangliomas and pheochromocytomas are sympathetic or parasympathetic tumors derived from the paraganglia and the adrenal medulla, respectively. Paragangliomas and pheochromocytomas can be sporadic or familial, the latter frequently being multifocal and possibly due to succinate dehydrogenase complex genes mutations. In addition, 12% of sporadic paragangliomas are related to covered succinate dehydrogenase complex mutations. The importance of identifying succinate dehydrogenase complex mutations is related to the risk for these patients of developing multiple tumors, including non-endocrine ones, showing an aggressive clinical presentation. Case presentation: We report the case of a 45-year-old Caucasian man with an indolent mass in his neck. Ultrasound of his neck, magnetic resonance imaging, and 1,4,7,10-tetraazacyclododecane-N(I),N(II),N(III),N(IIII)-tetraacetic acid(D)-Phe(1)-thy(3)-octreotide (68Ga-DOTATOC) positron emission tomography-computed tomography and endocrine work-up were consistent with a carotid body paraganglioma with concomitant nodal enlargement in several body regions, which turned out to be a follicular lymphoma at histology. He was found to carry a germline Succinate dehydrogenase subunit B gene (SDHB) mutation. Conclusion: It is crucial to look for a second malignancy in the case of a paraganglioma demonstrating succinate dehydrogenase complex germline mutations