Detect Spinons via Spin Transport

Existence of spinons is the defining property of quantum spin liquids. These exotic excitations have (fractionalized) spin quantum number and no electric charge, and have been proposed to form Fermi surfaces in the recently discovered organic spin liquid candidates. However direct probes for them are still lacking. In this paper we propose to experimentally identify the spinons by measuring the spin current flowing through the spin liquid candidate materials, which would be a direct test for the existence of spin-carrying mobile excitations. By the nonequilibrium Green function technique we evaluate the spin current through the interface between a Mott insulator and a metal under a spin bias, and find that different kinds of Mott insulators, including quantum spin liquids, can be distinguished by different relations between the spin bias and spin current, In the end we will also discuss relations to experiments and estimate experimentally relevant parameters.Comment: 7 pages with appendix, 3 figure

Disorder and metal-insulator transitions in Weyl semimetals

The Weyl semimetal (WSM) is a newly proposed quantum state of matter. It has Weyl nodes in bulk excitations and Fermi arcs surface states. We study the effects of disorder and localization in WSMs and find three exotic phase transitions. (I) Two Weyl nodes near the Brillouin zone boundary can be annihilated pairwise by disorder scattering, resulting in the opening of a topologically nontrivial gap and a transition from a WSM to a three-dimensional (3D) quantum anomalous Hall state. (II) When the two Weyl nodes are well separated in momentum space, the emergent bulk extended states can give rise to a direct transition from a WSM to a 3D diffusive anomalous Hall metal. (III) Two Weyl nodes can emerge near the zone center when an insulating gap closes with increasing disorder, enabling a direct transition from a normal band insulator to a WSM. We determine the phase diagram by numerically computing the localization length and the Hall conductivity, and propose that the exotic phase transitions can be realized on a photonic lattice.Comment: 7 pages with appendix, 6 figure

B\to X_s\gamma, X_s l^+ l^- decays and constraints on the mass insertion parameters in the MSSM

In this paper, we study the upper bounds on the mass insertion parameters $(\delta^{q}_{AB})_{ij}$ in the minimal supersymmetric standard model (MSSM). We found that the information from the measured branching ratio of $B \to X_s l^+ l^-$ decay can help us to improve the upper bounds on the mass insertions parameters \left (\delta^{u,d}_{AB})_{3j,i3}. Some regions allowed by the data of $Br(B \to X_s \gamma)$ are excluded by the requirement of a SM-like $C_{7\gamma}(m_b)$ imposed by the data of $Br(B \to X_s l^+ l^-)$.Comment: 16 pages, 5 eps figure files, typos remove

Dissipative Chiral Channels, Ohmic Scaling and Half-integer Hall Conductivity from the Relativistic Quantum Hall Effect

The quantum Hall effect (QHE), which was observed in 2D electron gas under an external magnetic field, stands out as one of the most remarkable transport phenomena in condensed matter. However, a long standing puzzle remains regarding the observation of the relativistic quantum Hall effect (RQHE). This effect, predicted for a single 2D Dirac cone immersed in a magnetic field, is distinguished by the intriguing feature of half-integer Hall conductivity (HIHC). In this work, we demonstrate that the condensed-matter realization of the RQHE and the direct measurement of the HIHC are feasible by investigating the underlying quantum transport mechanism. We reveal that the manifestation of HIHC is tied to the presence of dissipative half-integer quantized chiral channels circulating along the interface of the RQHE system and a Dirac metal. Importantly, we find that the Ohmic scaling of the longitudinal conductance of the system plays a key role in directly measuring the HIHC in experiments. Furthermore, we propose a feasible experimental scheme based on the 3D topological insulators to directly measure the HIHC. Our findings not only uncover the distinct transport mechanism of the HIHC for the RQHE, but also paves the way to the measurement of the HIHC in future experiments.Comment: 14 pages, 9 figure

A Less Toxic Heparin Antagonist—Low Molecular Weight Protamine

A new thirteen amino acid peptide, named low molecular weight protamine (LMWP), was obtained through the enzymatic digestion of native protamine. Both in vitro and in vivo results showed that LMWP fully maintained the heparin neutralization function of protamine but had much lower immunogenicity and antigenicity. Unlike protamine, neither LMWP nor LMWP/heparin complexes caused significant blood platelet aggregation in rats. These results suggest that LMWP can be used as a substitute for protamine for developing a new generation of nontoxic heparin antagonists.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45793/1/10541_2004_Article_462566.pd

Gastric organoids: Progress and remaining challenges

The stomach is a complex and physiologically necessary organ, yet large differences in physiology between mouse and human stomachs have impeded translation of physiological discoveries and drug screens performed using murine gastric tissues. Gastric cancer (GC) is a global health threat, with a high mortality rate and limited treatment options. The heterogeneous nature of GC makes it poorly suited for current one size fits all standard treatments. In this review, we discuss the rapidly evolving field of gastric organoids, with a focus on studies expanding cultures from primary human tissues and describing the benefits of mouse organoid models. We introduce the differing methods for culturing healthy gastric tissue from adult tissues or pluripotent stem cells, discuss the promise these systems have for preclinical drug screens, and highlight applications of organoids for precision medicine. Finally, we discuss the limitations of these models and look to the future to present potential ways gastric organoids will advance treatment options for patients with GC

Spawning rings of exceptional points out of Dirac cones

The Dirac cone underlies many unique electronic properties of graphene and topological insulators, and its band structure--two conical bands touching at a single point--has also been realized for photons in waveguide arrays, atoms in optical lattices, and through accidental degeneracy. Deformations of the Dirac cone often reveal intriguing properties; an example is the quantum Hall effect, where a constant magnetic field breaks the Dirac cone into isolated Landau levels. A seemingly unrelated phenomenon is the exceptional point, also known as the parity-time symmetry breaking point, where two resonances coincide in both their positions and widths. Exceptional points lead to counter-intuitive phenomena such as loss-induced transparency, unidirectional transmission or reflection, and lasers with reversed pump dependence or single-mode operation. These two fields of research are in fact connected: here we discover the ability of a Dirac cone to evolve into a ring of exceptional points, which we call an "exceptional ring." We experimentally demonstrate this concept in a photonic crystal slab. Angle-resolved reflection measurements of the photonic crystal slab reveal that the peaks of reflectivity follow the conical band structure of a Dirac cone from accidental degeneracy, whereas the complex eigenvalues of the system are deformed into a two-dimensional flat band enclosed by an exceptional ring. This deformation arises from the dissimilar radiation rates of dipole and quadrupole resonances, which play a role analogous to the loss and gain in parity-time symmetric systems. Our results indicate that the radiation that exists in any open system can fundamentally alter its physical properties in ways previously expected only in the presence of material loss and gain

The Reproducibility of Lists of Differentially Expressed Genes in Microarray Studies

Reproducibility is a fundamental requirement in scientific experiments and clinical contexts. Recent publications raise concerns about the reliability of microarray technology because of the apparent lack of agreement between lists of differentially expressed genes (DEGs). In this study we demonstrate that (1) such discordance may stem from ranking and selecting DEGs solely by statistical significance (P) derived from widely used simple t-tests; (2) when fold change (FC) is used as the ranking criterion, the lists become much more reproducible, especially when fewer genes are selected; and (3) the instability of short DEG lists based on P cutoffs is an expected mathematical consequence of the high variability of the t-values. We recommend the use of FC ranking plus a non-stringent P cutoff as a baseline practice in order to generate more reproducible DEG lists. The FC criterion enhances reproducibility while the P criterion balances sensitivity and specificity