Pattern formation in finite size non-equilibrium systems and models of morphogenesis

Two canonical pattern forming systems, the Rayleigh-Benard convection and the Turing mechanism for biological pattern formation, are compared. The similarity and fundamental differences in the mathematical structure of the two systems are addressed, with special emphasis on how the linear onset of patterns is affected by the finite size and the boundary conditions. Our analysis is facilitated by continuously varying the boundary condition, from one that admits simple algebraic solution of the problem but is unrealistic to another which is physically realizable. Our investigation shows that the size dependence of the convection problem can be considered generic, in the sense that for the majority of boundary conditions the same trend is to be observed, while for the corresponding Turing mechanism one will rely crucially on the assumed boundary conditions to ensure that a particular sequence of patterns be picked up as the system grows in size. This suggests that, although different systems might exhibit similar pattern forming features, it is still possible to distinguish them by characteristics which are specific to the individual models

Inventory Model with Seasonal Demand: A Specific Application to Haute Couture

In the stochastic multiperiod inventory problem, a vast majority of the literature deals with demand volume uncertainty. Other dimensions of uncertainty have generally been overlooked. In this paper, we develop a newsboy formulation for the aggregate multiperiod inventory problem intended for products of short sales season and without replenishments. A distinguishing characteristic of our formulation is that it takes a time dimension of demand uncertainty into account. The proposed model is particularly suitable for applications in haute couture, i.e., high fashion industry. The model determines the time of switching primary sales effort from one season to the next as well as optimal order quantity for each season with the objective of maximizing expected profit over the planning horizon. We also derive the optimality conditions for the time of switching primary sales effort and order quantity. Furthermore, we show that if time uncertainty and volume uncertainty are independent, order quantity becomes the main decision over the interval of the primary selling season. Finally, we demonstrate that the results from the two-season case can be directly extended to the multi-season case and the limited resource multiple-item case

Gender Discrimination in Hong Kong Churches

Institutional sexism continues to hinder women’s career progression, creating hurdles that women must overcome in the workplace. The context of institutional religion is not exempt from such gender-related injustice, and women in leadership positions within the ecclesiastical system are vulnerable to overt gender inequality. This article examines gender disenfranchisement in Hong Kong churches. It utilizes data gathered and processed through the qualitative research methodology of Interpretative Phenomenological Analysis (IPA) to analyze the lived experience of clergywomen in English-speaking faith communities in Hong Kong. The study reveals the indisputable presence of institutional sexism manifested and perpetuated by a host of gender marginalizing treatments which I refer to as gender discrimination. These oppressive, discriminatory practices range in gravity and verbal explicitness, and have been categorized as physical, emotional, and theological in nature. The pervasive and acute discriminatory behaviors collectively diminish women’s voices and authority and maintain the power disparity between women and men. This article deepens the understanding of the patriarchal status quo of the Hong Kong church, expands on the existing research corpus on gender discrimination in the church, and hopes to join in the global feminist dialogue to support provisions to address the detrimental impacts on women serving in leadership roles

A practical approach in clarifying legal drafting: Delphi and case study in Malaysia

Purpose - Legal drafting is one of the root causes for interpretation errors and misunderstandings in construction contracts. Moreover, most construction personnel do not have legally trained background. Therefore, the purpose of this paper is to determine the feasible use and practicality of Plain English in clarifying legal drafting in Malaysian construction contracts. Design/methodology/approach - Two research approaches were adopted, namely, Delphi research and case study. The Delphi method was to elicit local experts' knowledge and consensus view on the given examples of restructured contract provisions. Next, an actual case study was conducted to examine and substantiate the research findings by critically reviewing the latest and revised standard form of contract for its Plain English usage. Findings - The Delphi research shows that all the restructured contract provisions were agreed by the local experts; whereas the case study reveals that significant changes and the acceptance of Plain English in most of the contract provisions. Originality/value - The research renders insightful references in clarifying legal drafting in construction contracts based on the empirical evidence and the use of Plain English from the Malaysian scenario. It also contributes into the resolution of contractual differences and conflicts caused by the misunderstandings or interpretation problems

Protein-mediated DNA Loop Formation and Breakdown in a Fluctuating Environment

Living cells provide a fluctuating, out-of-equilibrium environment in which genes must coordinate cellular function. DNA looping, which is a common means of regulating transcription, is very much a stochastic process; the loops arise from the thermal motion of the DNA and other fluctuations of the cellular environment. We present single-molecule measurements of DNA loop formation and breakdown when an artificial fluctuating force, applied to mimic a fluctuating cellular environment, is imposed on the DNA. We show that loop formation is greatly enhanced in the presence of noise of only a fraction of $k_B T$, yet find that hypothetical regulatory schemes that employ mechanical tension in the DNA--as a sensitive switch to control transcription--can be surprisingly robust due to a fortuitous cancellation of noise effects

Interplay among unstable modes in films over permeable walls

The stability of open-channel flows (or film flows) has been extensively investigated for the case of impermeable smooth walls. In contrast, despite its relevance in many geophysical and industrial flows, the case that considers a permeable rather than an impermeable wall is almost unexplored. In the present work, a linear stability analysis of a film falling over a permeable and inclined wall is developed and discussed. The focus is on the mutual interaction between three modes of instability, namely, the well-known free-surface and hydrodynamic (i.e. shear) modes, which are commonly observed in open-channel flows over impermeable walls, plus a new one associated with the flow within the permeable wall (i.e. the porous mode). The flow in this porous region is modelled by the volume-averaged Navier-Stokes equations and, at the wall interface, the surface and subsurface flow are coupled through a stress-jump condition, which allows one to obtain a continuous velocity profile throughout the whole flow domain. The generalized eigenvalue problem is then solved via a novel spectral Galerkin method, and the whole spectrum of eigenvalues is presented and physically interpreted. The results show that, in order to perform an analysis with a full coupling between surface and subsurface flow, the convective terms in the volume-averaged equations have to be retained. In previous studies, this aspect has never been considered. For each kind of instability, the critical Reynolds number (${\mathit{Re}}_{c}$) is reported for a wide range of bed slopes ($\theta$) and permeabilities ($\sigma$). The results show that the free-surface mode follows the behaviour that was theoretically predicted by Benjamin and Yih for impermeable walls and is independent of wall permeability. In contrast, the shear mode shows a high dependence on $\sigma$: at $\sigma = 0$ the behaviour of ${\mathit{Re}}_{c} (\theta )$ recovers the well-known non-monotonic behaviour of the impermeable-wall case, with a minimum at \theta \sim 0. 05\textdegree . However, with an increase in wall permeability, ${\mathit{Re}}_{c}$ gradually decreases and eventually recovers a monotonic decreasing behaviour. At high values of $\sigma$, the porous mode of instability also occurs. A physical interpretation of the results is presented on the basis of the interplay between the free-surface-induced perturbation of pressure, the increment of straining due to shear with the increase in slope, and the shear stress condition at the free surface. Finally, the paper investigates the extent to which Squire's theorem is applicable to the problem presented herei

Crystallization of Adenylylsulfate Reductase from Desulfovibrio gigas: A Strategy Based on Controlled Protein Oligomerization

Adenylylsulfate reductase (adenosine 5′-phosphosulfate reductase, APS reductase or APSR, E.C.1.8.99.2) catalyzes the conversion of APS to sulfite in dissimilatory sulfate reduction. APSR was isolated and purified directly from massive anaerobically grown Desulfovibrio gigas, a strict anaerobe, for structure and function investigation. Oligomerization of APSR to form dimers–α_2β_2, tetramers–α_4β_4, hexamers–α_6β_6, and larger oligomers was observed during purification of the protein. Dynamic light scattering and ultracentrifugation revealed that the addition of adenosine monophosphate (AMP) or adenosine 5′-phosphosulfate (APS) disrupts the oligomerization, indicating that AMP or APS binding to the APSR dissociates the inactive hexamers into functional dimers. Treatment of APSR with β-mercaptoethanol decreased the enzyme size from a hexamer to a dimer, probably by disrupting the disulfide Cys156—Cys162 toward the C-terminus of the β-subunit. Alignment of the APSR sequences from D. gigas and A. fulgidus revealed the largest differences in this region of the β-subunit, with the D. gigas APSR containing 16 additional amino acids with the Cys156—Cys162 disulfide. Studies in a pH gradient showed that the diameter of the APSR decreased progressively with acidic pH. To crystallize the APSR for structure determination, we optimized conditions to generate a homogeneous and stable form of APSR by combining dynamic light scattering, ultracentrifugation, and electron paramagnetic resonance methods to analyze the various oligomeric states of the enzyme in varied environments

Preventing transition to turbulence: a viscosity stratification does not always help

In channel flows a step on the route to turbulence is the formation of streaks, often due to algebraic growth of disturbances. While a variation of viscosity in the gradient direction often plays a large role in laminar-turbulent transition in shear flows, we show that it has, surprisingly, little effect on the algebraic growth. Non-uniform viscosity therefore may not always work as a flow-control strategy for maintaining the flow as laminar.Comment: 9 pages, 8 figure