Neuro-Dynamic Programming for Radiation Treatment Planning

In many cases a radiotherapy treatment is delivered as a series of smaller dosages over a period of time. Currently, it is difficult to determine the actual dose that has been delivered at each stage, precluding the use of adaptive treatment plans. However, new generations of machines will give more accurate information of actual dose delivered, allowing a planner to compensate for errors in delivery. We formulate a model of the day-to-day planning problem as a stochastic linear program and exhibit the gains that can be achieved by incorporating uncertainty about errors during treatment into the planning process. Due to size and time restrictions, the model becomes intractable for realistic instances. We show how neuro-dynamic programming can be used to approximate the stochastic solution, and derive results from our models for realistic time periods. These results allow us to generate practical rules of thumb that can be immediately implemented in current planning technologies.\ud \ud This material is based on research partially supported by the National Science Foundation Grants ACI-0113051 and CCR-9972372, the Air Force Office of Scientific Research Grant F49620-01-1-0040, Microsoft Corporation and the Guggenheim Foundation

Data report: IODP Expedition 339 Site U1391: an improved splice and preliminary age model on the basis of XRF data

With the objective to reconstruct past primary production on the southwest Portuguese margin at orbital and millennial timescales through the Pleistocene, we chose to compare two sites recovered during Expedition 339 at similar latitude but different distances to the coast (Sites U1385 and U1391). Site U1385 has a well-established chronology, but for Site U1391 no isotope data are yet available. In order to develop a correct chronology without isotope data, we performed XRF analysis of cores from Holes U1391A and U1391B between 76.51 and 205.77 mbsf. With these data, in particular using log(Ca/Ti) and log(Ca/Fe), it was possible to enhance the Site U1391 splice and to establish an age model based on the correlation to the well-defined and robust Site U1385 age model.UID/Multi/04326/2019;info:eu-repo/semantics/publishedVersio

Studying the past of Mediterranean outflow based on 230th excess inventories and contourites

The Mediterranean Outflow water (MOW) comes out from the Mediterranean Sea and then contours the northern slope of the Cadiz Gulf. Along its way to the southern Portuguese Margin, it divides itself into three levels flowing at different depths, 400 m, 800 m and 1200 m, respectively. These different pathways induce a series of contourites along the Cadiz slope as well as some sedimentary drifts, such as the Faro Drift. Based on the assumption that the sedimentologic characteristics of these contourites should give some light on the history of MOW velocity and intensity variability, two long sedimentary cores collected during the Marion Dufresnes 114/Images cruise in 1999 have been studied. The sampling sites of these two cores, MD99-2336 and MD99-2339, located in the Cadiz Gulf at 690 and 1177 m water column depths respectively, are thus, actually, below the first level and in the main core of the MOW third level. Along time, variations in these current levels, parallel to the slope, should then influence the existence and characteristics of contourites in both sedimentary records. For this purpose, thorium-230 (230Th) as well as granulometric and micropaleontologic analysis have been undergone at high resolution on the 4 uppermost meters spanning MIS1 to LGM times. The referred current prints can be detected by analysing surface and down core sediment for its 230Th content. This radioisotope is produced by the radioactive decay of uranium-234 which content in oceanic waters is known. Therefore, its production rate in the water column can be estimated as a linear function of the water depth (~ 2.6 dpm/cm2.ka for 1 km water depth). As 230Th is almost insoluble, it will sink to the oceanic floor together with the settling particles. This vertical flux to the underlying sediment is considered, in a first order approximation, equal to its production rate in the water column. On this basis, the 230Th excess in the sediment becomes a proxy for sedimentation versus erosion processes accordingly to the sign of the difference between the total and the vertical 230Th flux, i.e. if it is, respectively, positive or negative. With this method it is then possible to extrapolate on the location of the high velocity core area and whether its intensity changed or not looking at the inventory of excess 230Th in the contourite units. We acknowledge FEDER and OE that financed this study through the Portuguese Foundation for Science and Technology (PDCTM/PP/MAR/15297/1999)

Collaborative Preference: The Role of Homophily, Multiplexity, and Advantageous Network Position across Small and Medium-sized Organizations

The purpose of this paper is to examine collaboration between individuals across organizations. While both for profit and not-for-profit organizations utilize collaborative efforts, the factors that are important for bringing individuals and businesses together for collaboration still remain somewhat unresolved. In this paper, colleague similarity, the quality of pre-existing relationships, and the relative power of the other colleague are all examined for their correlation with the desirability of collaboration with that individual. In a study of pastors of small and medium sized churches in a southwestern protestant conference, we examined these areas through the lenses of homophily theory, multiplicity theories, and network positioning theories and found support for each of our hypotheses. Implications for management as well as future research directions are also presented

Photo editing: Enhancing social media images to reflect appearance ideals

Many of the images used in traditional forms of mass media have been modified to portray unrealistic and idealised beauty characteristics. Further to this, members of the general public have now begun to digitally enhance their own pictures for social media posts, in order to fulfil these often unattainable standards. Ella Guest explores the impact exposure to idealised images of peers may have on health and wellbein