Enhancing the significance of gravitational wave bursts through signal classification

The quest to observe gravitational waves challenges our ability to discriminate signals from detector noise. This issue is especially relevant for transient gravitational waves searches with a robust eyes wide open approach, the so called all- sky burst searches. Here we show how signal classification methods inspired by broad astrophysical characteristics can be implemented in all-sky burst searches preserving their generality. In our case study, we apply a multivariate analyses based on artificial neural networks to classify waves emitted in compact binary coalescences. We enhance by orders of magnitude the significance of signals belonging to this broad astrophysical class against the noise background. Alternatively, at a given level of mis-classification of noise events, we can detect about 1/4 more of the total signal population. We also show that a more general strategy of signal classification can actually be performed, by testing the ability of artificial neural networks in discriminating different signal classes. The possible impact on future observations by the LIGO-Virgo network of detectors is discussed by analysing recoloured noise from previous LIGO-Virgo data with coherent WaveBurst, one of the flagship pipelines dedicated to all-sky searches for transient gravitational waves

Senescence in hepatic stellate cells as a mechanism of liver fibrosis reversal: a putative synergy between retinoic acid and PPAR-gamma signalings

Hepatic stellate cells (HSCs), also known as perisinusoidal cells, are pericytes found in the perisinusoidal space of the liver. HSCs are the major cell type involved in liver fibrosis, which is the formation of scar tissue in response to liver damage. When the liver is damaged, stellate cells can shift into an activated state, characterized by proliferation, contractility and chemotaxis. The activated HSCs secrete collagen scar tissue, which can lead to cirrhosis. Recent studies have shown that in vivo activation of HSCs by fibrogenic agents can eventually lead to senescence of these cells, which would contribute to reversal of fibrosis although it may also favor the insurgence of liver cancer. HSCs in their non-active form store huge amounts of retinoic acid derivatives in lipid droplets, which are progressively depleted upon cell activation in injured liver. Retinoic acid is a metabolite of vitamin A (retinol) that mediates the functions of vitamin A, generally required for growth and development. The precise function of retinoic acid and its alterations in HSCs has yet to be elucidated, and nonetheless in various cell types retinoic acid and its receptors (RAR and RXR) are known to act synergistically with peroxisome proliferator-activated receptor gamma (PPAR-gamma) signaling through the activity of transcriptional heterodimers. Here, we review the recent advancements in the understanding of how retinoic acid signaling modulates the fibrogenic potential of HSCs and proposes a synergistic combined action with PPAR-gamma in the reversal of liver fibrosis

Multiscale seismic characterization and monitoring of a potentially unstable rock mass: the Madonna del Sasso (NW Italy) rockfall

Active (e.g. surface refraction and cross-hole tomography) and passive (monitoring of microseismic events) seismic methods can provide a proper characterization of the inner structure of the rock mass and are key to the comprehension of the mechanisms enhancing the instability of rock masses.We propose a multiscale approach for the characterization of the potentially unstable granitic cliff of Madonna del Sasso (NW Italian Alps) integrating prospecting surveys, laboratory tests, long-term microseismic monitoring and numerical modeling. The complex 3-D fracture setting, the geometry of the unstable sector was achieved through field observations, photogrammetric geomechanical analysis and interpretation of on-site seismic surveys, which revealed to be fundamental for constraining the fracture geometry and opening at depth within the rock mass. Physical and mechanical properties of the investigated medium were obtained through laboratory tests on granite samples. Continuous monitoring of ambient vibration at the site (October 2013 - present) did not highlight irreversible changes in the rock mass properties precursory to an acceleration to failure. However, a strong thermal control was found to govern the stability of the cliff, with reversible seasonal opening and closing of fractures resulting from thermal contraction and expansion. Moreover, the vibration modes of the unstable sector were found to be strongly controlled by the complex 3-D geometry of the main fracture planes affecting the site. Detection and location of microseismic events within the prone-to-fall rock mass highlighted the concentration of low energy releases close to the major fracture planes. Microseismic monitoring at the laboratory scale of deformation and rupture processes is expected to further highlight the relationships between energy release, seismic signatures and seismic sources. Finally, finite element modeling on the 3-D geometry allowed an experimental validation and interpretation

Physical properties of seismogenic Triassic evaporites in the northern Appennines (Central Italy)

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Relating seismic velocities, thermal cracking and permeability in Mt. Etna and Iceland basalts

We report simultaneous laboratory measurements of seismic velocities and fluid permeability on lava flow basalt from Etna (Italy) and columnar basalt from Seljadur (Iceland). Measurements were made in a servo-controlled steady-state-flow permeameter at effective pressures from 5–80 MPa, during both increasing and decreasing pressure cycles. Selected samples were thermally stressed at temperatures up to 900 °C to induce thermal crack damage. Acoustic emission output was recorded throughout each thermal stressing experiment. At low pressure (0–10 MPa), the P-wave velocity of the columnar Seljadur basalt was 5.4 km/s, while for the Etnean lava flow basalt it was only 3.0–3.5 km/s. On increasing the pressure to 80 MPa, the velocity of Etnean basalt increased by 45%–60%, whereas that of Seljadur basalt increased by less than 2%. Furthermore, the velocity of Seljadur basalt thermally stressed to 900 °C fell by about 2.0 km/s, whereas the decrease for Etnean basalt was negligible. A similar pattern was observed in the permeability data. Permeability of Etnean basalt fell from about 7.5×10−16 m2 to about 1.5×10−16 m2 over the pressure range 5–80 MPa, while that for Seljadur basalt varied little from its initial low value of 9×10−21 m2. Again, thermal stressing significantly increased the permeability of Seljadur basalt, whilst having a negligible effect on the Etnean basalt. These results clearly indicate that the Etnean basalt contains a much higher level of crack damage than the Seljadur basalt, and hence can explain the low velocities (3–4 km/s) generally inferred from seismic tomography for the Mt. Etna volcanic edifice

Relating physical properties to temperature-induced damage in carbonate rocks

Carbonate rocks have a widespread diffusion in the Earth crust and are extensively used in cultural heritage and buildings. These rocks can be naturally or anthropically exposed to high temperatures. Consequently, relating physical properties to temperature-induced damage is extremely important. Six sets of compositionally and texturally different carbonate rocks, spanning from limestones and marbles to dolomitic marbles, were analysed in this study. Different physical properties, such as porosity, seismic wave velocities and electrical resistivity, were measured before and after thermal treatments with heating/cooling ranges between 105 and 600°C. Microstructural observations and optical analyses were used to investigate how temperature-induced damage affects the physical measured properties of the different microstructures. This integrated approach allowed to define a generalised relationship between physical properties and thermal-induced damage, by way of an induced damage index valid for a broad suite of carbonate rocks