11 research outputs found
Some extensions of the class of convex bodies
We introduce and study a new class of \eps-convex bodies (extending the
class of convex bodies) in metric and normed linear spaces. We analyze
relations between characteristic properties of convex bodies, demonstrate how
\eps-convex bodies connect with some classical results of Convex Geometry, as
Helly theorem, and find applications to geometric tomography. We introduce the
notion of a circular projection and investigate the problem of determination of
\eps-convex bodies by their projection-type images. The results generalize
corresponding stability theorems by H. Groemer
Strategies for the Identification and Analysis of Viral Immune-Evasive Genes — Cytomegalovirus as an Example
The role of cytokine profile and lymphocyte subsets in the severity of coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis
Natural Killer Cell IFNÎł Secretion is Profoundly Suppressed Following Colorectal Cancer Surgery
Conventional CD4+ T cells present bacterial antigens to induce cytotoxic and memory CD8+ T cell responses
Natural Killer (NK) Cells in Antibacterial Innate Immunity: Angels or Devils?
Natural killer (NK) cells were first described as immune leukocytes that could kill tumor cells and soon after were reported to kill virus-infected cells. In the mid-1980s, 10 years after their discovery, NK cells were also demonstrated to contribute to the fight against bacterial infection, particularly because of crosstalk with other leukocytes. A wide variety of immune cells are now recognized to interact with NK cells through the production of cytokines such as interleukin (IL)-2, IL-12, IL-15 and IL-18, which boost NK cell activities. The recent demonstration that NK cells express pattern recognition receptors, namely Toll-like and nucleotide oligomerization domain (NOD)-like receptors, led to the understanding that these cells are not only under the control of accessory cells, but can be directly involved in the antibacterial response thanks to their capacity to recognize pathogen-associated molecular patterns. Interferon (IFN)-Îł is the predominant cytokine produced by activated NK cells. IFN-Îł is a key contributor to antibacterial immune defense. However, in synergy with other inflammatory cytokines, IFN-Îł can also lead to deleterious effects similar to those observed during sepsis. Accordingly, as the main source of IFN-Îł in the early phase of infection, NK cells display both beneficial and deleterious effects, depending on the circumstances