29 research outputs found
Repair of Impaired Host Peroxisomal Properties Cropped Up Due to Visceral Leishmaniasis May Lead to Overcome Peroxisome Related Genetic Disorder Which May Develop Later After Treatment
Standardization of Ajmodadi churna, a polyherbal formulation
Standardization of herbal formulations is essential in order to assess the quality of drugs, based on the concentration of their active principles. This article reports on standardization of Ajmodadi churna, a polyherbal ayurvedic medicine used as a carminative and an antispasmodic, and is a strong wormifuge, and helps in all painful conditions like sciatica and stiffness in back and also restores normal digestive functions. Ajmodadi churna was prepared as per Ayurvedic Formulary of India. In-house preparation and the marketed drug have been standardized on the basis of organoleptic characters, physical characteristics, and physico-chemical properties. The set parameters were found to be sufficient to evaluate the churna and can be used as reference standards for the quality control/quality assurance laboratory of a Pharmaceutical house
Synthesis of naphtho[2, 1<i>-b </i>]furo[3,2-<i>e</i>]-1,4-diazepin-2-ones and naphtho[2, 1-<i>b</i>]furo[3,2-<i>e</i>]-1,3,4-triazepin-2-ones of pharmacological interest
1537-15432-Hydroxy-1-naphthonitrile
1 on treatment with different haloketones affords corresponding
2-acyl-3-aminonaphtho[2,1-b] furans 2a-c. The compounds 2a-c
on refluxing with chloroacetyl chloride produce 3-chloroacetamido-2-acylnaphtho[2,1-b]furans
3a-c, which on subsequent treatment with methanolic ammonia yields the
desired naphtho[2,1-b] furo[3,2-e] -1,4-diazepin-2-ones 4a-c.
The synthesis of another intermediate 3-aminonaphtho[2, 1-b] furan-2-carboxylate
5, is accomplished by reacting 1 with ethyl chloroacetate. The compound 5
is converted into 1H-2,3,4,5-tetrahydronaphtho[2, 1-b]furo[3,2-e]-1
,4-diazepin-2,5-dione 7 via ethyl 3-chloroacetamido naphtho[2,1-b]furan-2-carboxylate
6. The reaction of 2a-c with ethyl chloroformate results in the
formation of 2-acyl-3 carbethoxyaminonaphtho[2,1-b ]furans 5a-c,
which are further converted into different hydrazones 9a-i. The
cyclisation of hydrazones 9a-i to 5-alkyl/aryl-3-substituted-1H-2,3-dihydronaphtho[2,1-b)
furo[3,2-e]-1 ,3,4-triazepin-2-ones 10a-i is achieved by
refluxing in acetic acid. The structures of newly synthesized compounds have
been established by elemental analysis and spectral data. Their antimicrobial,
anthelmintic and analgesic activities have been evaluated