A test of tau neutrino interactions with atmospheric neutrinos and K2K

The presence of a tau component in the flux of atmospheric neutrinos inside the Earth, due to flavor oscillations, makes these neutrinos a valuable probe of interactions of the tau neutrino with matter. We study -- analytically and numerically -- the effects of nonstandard interactions in the nu_e-nu_tau sector on atmospheric neutrino oscillations, and calculate the bounds on the exotic couplings that follow from combining the atmospheric neutrino and K2K data. We find very good agreement between numerical results and analytical predictions derived from the underlying oscillation physics. While improving on existing accelerator bounds, our bounds still allow couplings of the size comparable to the standard weak interaction. The inclusion of new interactions expands the allowed region of the vacuum oscillation parameters towards smaller mixing angles, 0.2 ~< sin^2 theta_{23} ~< 0.7, and slightly larger mass squared splitting, 1.5 * 10^{-3} eV^2 ~< |\Delta m^2_{23}| ~< 4.0 * 10^{-3} eV^2, compared to the standard case. The impact of the K2K data on all these results is significant; further important tests of the nu_e-nu_tau exotic couplings will come from neutrino beams experiments such as MINOS and long baseline projects.Comment: 8 figures, some typos corrected, minor editing in the reference

Evaluation of Brazilian wild Hevea germplasm in India for cold tolerance: Variability and character associations in juvenile growth phase

Natural rubber (Hevea brasiliensis), cultivation has been extended to non-traditional regions due to limited scope of further expansion in traditional rubber growing areas in India. These areas are often confronted with various abiotic stresses especially temperature extremes. A set of 18 wild accessions, two popular clones along with two control clones RRIM 600 and Haiken 1, were evaluated in the juvenile growth phase at the Regional Experiment Station of the Rubber Research Institute of India, Nagrakata, West Bengal, a sub-Himalayan cold prone region of India. The genotypes exhibited highly significant clonal differences (P&lt;0.01) for all the eight quantitative traits. During the pre-winter period, the number of leaves per plant ranged from 14.2 (AC 3074) to 47.6 (MT 2229). In the post winter period maximum leaves per plant was recorded in MT 900 (29.27) comparable to the control clone Haiken 1 (28.20), while the accession AC 3293 recorded very high loss in leaves. An increase in number of whorls per plant during winter period was noted in MT 1020 as compared to Haiken 1 (0.80). Increment of plant height during winter ranged from 6.53 cm (AC 3293) to 45.01 cm (MT 1020) as compared to the control clone Haiken 1 (40.73 cm). Girth ranged from 5.36 cm (AC 3293) to 11.53 cm (MT 915) while the control clone Haiken 1 recorded a girth of 10.50 cm. Girth was significantly correlated with the other growth traits. Based on rank sum values, the accessions were ranked for overall performance and the top 20 per cent of the potential accessions showing early growth vigour were identified. These can be used for the development of cold tolerant clones

Testing CPT Symmetry with Supernova Neutrinos

Diagnosing core of supernova requires favor-dependent reconstruction of three species of neutrino spectra, \nu_e, \bar{\nu}_{e} and \nu_x (a collective notation for \nu_{\mu}, \bar{\nu}_{\mu}, \nu_{\tau}, and \bar{\nu}_{\tau}). We point out that, assuming the information available, CPT symmetry can be tested with supernova neutrinos. We classify all possible level crossing patterns of neutrinos and antineutrinos into six cases and show that half of them contains only the CPT violating mass and mixing patterns. We discuss how additional informations from terrestrial experiments help identifying CPT violation by narrowing down the possible flux patterns. Although the method may not be good at precision test, it is particularly suited to uncover gross violation of CPT such as different mass patterns of neutrinos and antineutrinos. The power of the method is due to the nature of level crossing in supernova which results in the sensitivity to neutrino mass hierarchy and to the unique characteristics of in situ preparation of both \nu and \bar{\nu} beams. Implications of our discussion to the conventional analyses with CPT conservation are also briefly mentioned.Comment: 24 pages, 4 figures, discussion added on narrowing down flux patterns by terrestrial measuremen

Dystrophin glycoprotein complex dysfunction:a regulatory link between muscular dystrophy and cancer cachexia

SummaryCachexia contributes to nearly a third of all cancer deaths, yet the mechanisms underlying skeletal muscle wasting in this syndrome remain poorly defined. We report that tumor-induced alterations in the muscular dystrophy-associated dystrophin glycoprotein complex (DGC) represent a key early event in cachexia. Muscles from tumor-bearing mice exhibited membrane abnormalities accompanied by reduced levels of dystrophin and increased glycosylation on DGC proteins. Wasting was accentuated in tumor mdx mice lacking a DGC but spared in dystrophin transgenic mice that blocked induction of muscle E3 ubiquitin ligases. Furthermore, DGC deregulation correlated positively with cachexia in patients with gastrointestinal cancers. Based on these results, we propose that, similar to muscular dystrophy, DGC dysfunction plays a critical role in cancer-induced wasting

Hypusination of Eif5a Regulates Cytoplasmic TDP-43 Aggregation and Accumulation in a Stress-Induced Cellular Model

TAR DNA-binding protein 43 (TDP-43) is a nuclear RNA/DNA binding protein involved in mRNA metabolism. Aberrant mislocalization to the cytoplasm and formation of phosphorylated/aggregated TDP-43 inclusions remains the hallmark pathology in a spectrum of neurodegenerative diseases, including frontotemporal disorders and Alzheimer\u27s disease. Eukaryotic Translation Initiation Factor 5A undergoes a unique post-translation modification of lysine to hypusine (K50), which determines eIF5A binding partners. We used a sodium arsenite-induced cellular stress model to investigate the role of hypusinated eIF5A (eIF5AHypK50) in governing TDP-43 cytoplasmic mislocalization and accumulation in stress granule. Our proteomics and functional data provide evidence that eIF5A interacts with TDP-43 in a hypusine-dependent manner. Additionally, we showed that following stress TDP-43 interactions with eIF5AHypK50 were induced both in the cytoplasm and stress granules. Pharmacological reduction of hypusination or mutations of lysine residues within the hypusine loop decreased phosphorylated and insoluble TDP-43 levels. The proteomic and biochemical analysis also identified nuclear pore complex importins KPNA1/2, KPNB1, and RanGTP as interacting partners of eIF5AHypK50. These findings are the first to provide a novel pathway and potential therapeutic targets that require further investigation in models of TDP-43 proteinopathies

Decadal changes of the Western Arabian sea ecosystem

Historical data from oceanographic expeditions and remotely sensed data on outgoing longwave radiation, temperature, wind speed and ocean color in the western Arabian Sea (1950–2010) were used to investigate decadal trends in the physical and biochemical properties of the upper 300 m. 72 % of the 29,043 vertical profiles retrieved originated from USA and UK expeditions. Increasing outgoing longwave radiation, surface air temperatures and sea surface temperature were identified on decadal timescales. These were well correlated with decreasing wind speeds associated with a reduced Siberian High atmospheric anomaly. Shoaling of the oxycline and nitracline was observed as well as acidification of the upper 300 m. These physical and chemical changes were accompanied by declining chlorophyll-a concentrations, vertical macrofaunal habitat compression, declining sardine landings and an increase of fish kill incidents along the Omani coast

Three flavor neutrino oscillation analysis of atmospheric neutrinos in Super-Kamiokande

We report on the results of a three-flavor oscillation analysis using Super-Kamiokande~I atmospheric neutrino data, with the assumption of one mass scale dominance ($\Delta m_{12}^2$$=$0). No significant flux change due to matter effect, which occurs when neutrinos propagate inside the Earth for $\theta_{13}$$\neq$0, has been seen either in a multi-GeV $\nu_e$-rich sample or in a $\nu_\mu$-rich sample. Both normal and inverted mass hierarchy hypotheses are tested and both are consistent with observation. Using Super-Kamiokande data only, 2-dimensional 90 % confidence allowed regions are obtained: mixing angles are constrained to $\sin^2\theta_{13} < 0.14$ and $0.37 < \sin^2\theta_{23} < 0.65$ for the normal mass hierarchy. Weaker constraints, $\sin^2\theta_{13} < 0.27$ and $0.37 < \sin^2\theta_{23} < 0.69$, are obtained for the inverted mass hierarchy case.Comment: 7 figures, 3 table

Search for Electron Neutrino Appearance in a 250 km Long-baseline Experiment

We present a search for electron neutrino appearance from accelerator produced muon neutrinos in the K2K long baseline neutrino experiment. One candidate event is found in the data corresponding to an exposure of 4.8*10^19 protons on target. The expected background in the absence of neutrino oscillations is estimated to be 2.4+-0.6 events and is dominated by mis-identification of events from neutral current pi^0 production. We exclude the \nu_\mu to \nu_e oscillations at 90% C.L. for the effective mixing angle in 2-flavor approximation of sin^2(2theta_\mu_e) (~= 1/2 sin^2 2 th_13) > 0.15 at Delta m^2_\mu_e = 2.8*10^{-3} eV^2, the best fit value of the \nu_\mu disappearance analysis in K2K. The most stringent limit of sin^2(2theta_\mu_e) < 0.09 is obtained at Delta m^2_\mu_e = 6*10^{-3} eV^2.Comment: 5 pages with 2 figures embeded in two column revtex4 style. Accepted to be published in Phys. Rev. Let

Western Indian Ocean marine and terrestrial records of climate variability: a review and new concepts on land-ocean interactions since AD 1660

We examine the relationship between three tropical and two subtropical western Indian Ocean coral oxygen isotope time series to surface air temperatures (SAT) and rainfall over India, tropical East Africa and southeast Africa. We review established relationships, provide new concepts with regard to distinct rainfall seasons, and mean annual temperatures. Tropical corals are coherent with SAT over western India and East Africa at interannual and multidecadal periodicities. The subtropical corals correlate with Southeast African SAT at periodicities of 16–30 years. The relationship between the coral records and land rainfall is more complex. Running correlations suggest varying strength of interannual teleconnections between the tropical coral oxygen isotope records and rainfall over equatorial East Africa. The relationship with rainfall over India changed in the 1970s. The subtropical oxygen isotope records are coherent with South African rainfall at interdecadal periodicities. Paleoclimatological reconstructions of land rainfall and SAT reveal that the inferred relationships generally hold during the last 350 years. Thus, the Indian Ocean corals prove invaluable for investigating land–ocean interactions during past centuries