Biography and vulnerability: Loss, dying and death in the Romantic paintings of JMW Turner (1775-1851)

Copyright@ 2005 Edward Arnold (Publishers) Ltd.Narratives of suffering and vulnerability are an important theme in western art, the humanities and the social sciences. It is argued here that J.M.W. Turner's pictures, like those of many artists, are biographical tales. The central tenet of Turner's romantic art is the arousal of sensation and Turner's pictures include wonderfully evocative `visual poems' on the human experiences of loss, decline, `the fallacies of hope', grief and death. This paper first explores the connections between Turner's biography and his art through a discussion of several of Turner's key paintings. It then moves on to a more in-depth discussion of two pictures painted by Turner in 1842, when he was 67 years old: Peace — Burial at Sea, and War — The Exile and the Rock Limpet. These paintings can be seen as insightful biographical narratives on the embodiment of vulnerability. In conclusion, it is suggested that Turner's paintings of loss and death are valuable exemplars of the capacity of art to meld together biography, narrative, vulnerability, suffering and embodiment

Neuroscientists’ everyday experiences of ethics: The interplay of regulatory, professional, personal and tangible ethical spheres

Copyright @ 2013 The Authors. This article has been published using OnlineOpen. Re-use of this article is permitted in accordance with the Terms and Conditions set out at http://wileyonline library.com/onlineopen#OnlineOpen_Terms.The ethical issues neuroscience raises are subject to increasing attention, exemplified in the emergence of the discipline neuroethics. While the moral implications of neurotechnological developments are often discussed, less is known about how ethics intersects with everyday work in neuroscience and how scientists themselves perceive the ethics of their research. Drawing on observation and interviews with members of one UK group conducting neuroscience research at both the laboratory bench and in the clinic, this article examines what ethics meant to these researchers and delineates four specific types of ethics that shaped their day-to-day work: regulatory, professional, personal and tangible. While the first three categories are similar to those identified elsewhere in sociological work on scientific and clinical ethics, the notion of ‘tangible ethics’ emerged by attending to everyday practice, in which these scientists’ discursive distinctions between right and wrong were sometimes challenged. The findings shed light on how ethical positions produce and are, in turn, produced by scientific practice. Informing sociological understandings of neuroscience, they also throw the category of neuroscience and its ethical specificity into question, given that members of this group did not experience their work as raising issues that were distinctly neuro-ethical.Wellcome Trus

A role for transcriptional repressor methyl-CpG-binding protein 2 and plasticity-related gene serum- and glucocorticoid-inducible kinase 1 in the induction of inflammatory pain states

Activity-dependent changes in neurons of the rat superficial dorsal horn are crucial for the induction and maintenance of neuropathic and inflammatory pain states. To identify the molecular mechanisms underlying this sensitization of superficial dorsal horn neurons, we undertook a genome-wide microarray profiling of dorsal horn gene transcripts at various times after induction of peripheral inflammation of the rat ankle joint. At early time points, upregulation of gene expression dominated, but by 7 d, downregulation was predominant. Two to 24 h after inflammation, we identified a small number of highly upregulated transcripts previously shown to be repressed by the Methyl-CpG-binding protein 2 (MeCP2), including serum-and glucocorticoid-inducible kinase (SGK1) and FK 506 binding protein 5, genes known to be important in experience-dependent plasticity. A decrease in expression of SIN3A, a corepressor in the MeCP2 silencing complex, was also found after inflammation. Phosphorylation of MeCP2 regulates activity-dependent gene transcription, and crucially we found that MeCP2 was phosphorylated in lamina I projection neurons 1 h after induction of peripheral inflammation. Lamina I projection neurons have been shown to be essential for the development of most pain states. SGK1 protein was also localized, in part, to lamina I projection neurons, and its expression in the superficial dorsal horn increased after inflammation. Furthermore, antisense knock-down of SGK1 delayed the onset of inflammatory hyperalgesia by 24 h at least. Our results uncover an unexpected complexity in the regulation of gene expression, including the modulation of transcriptional repression, that accompanies development and maintenance of an inflammatory pain state

The changing perception in the artefacts used in the design practice through BIM adoption

When CAD (Computer Aided Design) was generally adopted in the early 1990’s, the hand drawn process was replaced with the CAD drawing but the nature of the artefacts / deliverables and the exchanges of information between disciplines remained fundamentally the same. The deliverables remained 2D representations of 3D forms and Specifications and Bill of Quantities. However, the building industry is under great pressure to provide value for money, sustainable design and construction. This has propelled the adoption of Building Information Modelling (BIM). BIM is a foundational tool for a team based lean design approach. It can enable the intelligent interrogation of design; provide a quicker and cheaper design production; better co-ordination of documentation; more effective change control; less repetition of processes; a better quality constructed product; and improved communication both for the architectural practice and across the supply chain. As BIM enables a new of working methodology, it entails the change in perceiving artefacts used and deliverables produced in the design and construction stages. In other words, defining what the informational issues are, who does what and who is responsible for what and the level of detail required at each stage in design and construction is critically important to adopt and implement BIM in the construction sector. This paper presents the key findings through the action research methodology about the change in the nature of artefacts and deliverables resulting from the BIM adoption in the KTP (Knowledge Transfer Partnership) project undertaken by the University of Salford and John McCall Architects

BIM adoption and implementation for architectural practices

Severe issues about data acquisition and management arise during the design creation and development due to complexity, uncertainty and ambiguity. BIM (Building Information Modelling) is a tool for a team based lean design approach towards improved architectural practice across the supply chain. However, moving from a CAD (Computer Aided Design) approach to BIM (Building Information Modelling) represents a fundamental change for individual disciplines and the construction industry as a whole. Although BIM has been implemented by large practices, it is not widely used by SMEs (Small and Medium Sized Enterprises). Purpose: This paper aims to present a systematic approach for BIM implementation for Architectural SMEs at the organizational level Design/Methodology/Approach: The research is undertaken through a KTP (Knowledge transfer Partnership) project between the University of Salford and John McCall Architects (JMA) a SME based in Liverpool. The overall aim of the KTP is to develop lean design practice through BIM adoption. The BIM implementation approach uses a socio-technical view which does not only consider the implementation of technology but also considers the socio-cultural environment that provides the context for its implementation. The action research oriented qualitative and quantitative research is used for discovery, comparison, and experimentation as it provides �learning by doing�. Findings: The strategic approach to BIM adoption incorporated people, process and technology equally and led to capacity building through the improvements in process, technological infrastructure and upskilling of JMA staff to attain efficiency gains and competitive advantages. Originality/Value: This paper introduces a systematic approach for BIM adoption based on the action research philosophy and demonstrates a roadmap for BIM adoption at the operational level for SME companie

The key performance indicators of the BIM implementation process

Contemporarily some firms in the construction industry are attempting to adopt a BIM method of working. Each of these attempts reflects a varying BIM adoption philosophy and inevitably different BIM technologies, implementation strategies and roadmaps. On the other hand, all these attempts are often motivated to attain competitive advantages for product delivery in the market place. The question of what the best method of adopting BIM has not been answered yet. That is to say, it is required to identify a standard method that will benchmark the different BIM adoption cases by comparing the efficiency gains in these cases: a standard benchmarking method can help the stakeholders to decide on the most appropriate strategies for themselves. This paper explains the live experience of BIM adoption in a KTP (Knowledge Transfer Partnership) project, undertaken between the University of Salford and John McCall Architects practicing in the housing and regeneration fields, with a particular focus on a set of KPIs that have been developed and tested through the action research strategy in the project. Weighting of these KPI’s has been developed from an architectural business perspectiv