3,964 research outputs found
Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity
Virus infection of mammalian cells is sensed by pattern recognition receptors and leads to an innate immune response that restricts virus replication and induces adaptive immunity. In response, viruses have evolved many countermeasures that enable them to replicate and be transmitted to new hosts, despite the host innate immune response. Poxviruses, such as vaccinia virus (VACV), have large DNA genomes and encode many proteins that are dedicated to host immune evasion. Some of these proteins are secreted from the infected cell, where they bind and neutralize complement factors, interferons, cytokines and chemokines. Other VACV proteins function inside cells to inhibit apoptosis or signalling pathways that lead to the production of interferons and pro-inflammatory cytokines and chemokines. In this review, these VACV immunomodulatory proteins are described and the potential to create more immunogenic VACV strains by manipulation of the gene encoding these proteins is discussed
Contrasting responses of native ant communities to invasion by an ant invader, Linepithema humile
Invasive alien species pose a serious threat to the integrity and function of natural ecosystems. Understanding how these invaders alter natural communities is therefore an important aspect in predicting the likely future outcomes of biological invasions. Many studies have documented the consequences of invasive alien species on native community structure, through the displacement and local extinction of native species. However, sampling methods and intensities are rarely standardised across such studies, meaning that it is not clear whether differences in response among native communities to the same invader species are due to biological differences between the invaded regions, or differences in the methodologies used. Here we use a matched sampling methodology to compare the effects of the Argentine ant (Linepithema humile Mayr) on native ant community assemblages in two distinct biogeographical regions that share similar ecologies: Girona (Spain) and Jonkershoek Nature Reserve (South Africa). We found a strong negative association between L. humile presence and native ant species richness within both geographic regions. However, the effects differed between the two study regions: in Girona, a single native ant species (Plagiolepis pygmaea) persisted in invaded sites; by contrast, substantially more native ant species persisted at invaded sites in Jonkershoek Nature Reserve. In addition, in Jonkershoek Nature Reserve, the abundance of certain native species appeared to increase in the presence of L. humile. This study therefore demonstrates the potential variable effects of an invasive species in contrasting locations within different biogeographical regions. Future work should explore the causes of this differential resistance among communities and expand standardised sampling approaches to more invaded zones to further explore how local biotic or abiotic conditions of a region determine the nature and extent of impact of L. humile invasion on native ant communities
Modulation of linguistic prediction by TDCS of the right lateral cerebellum
AbstractIt has been postulated recently that the cerebellum contributes the same prediction and learning functions to linguistic processing as it does towards motor control. For example, repetitive TMS over posterior-lateral cerebellum caused a significant loss in predictive language processing, as assessed by the latency of saccades to target items of spoken sentences, using the Visual World task. We aimed to assess the polarity-specific effects of cerebellar TDCS, hypothesising that cathodal TDCS should impair linguistic prediction, and anodal TDCS facilitate it. Our design also tested whether TDCS modulated associative learning in this task. A between groups (sham, anodal, cathodal) design was used, with concurrent stimulation during performance of a manual variation of the Visual World paradigm, and with assessment of latency reduction over repeated presentations of the spoken sentences. Mixed model ANOVA was used to analyse change in response latency. Cathodal TDCS decreased participantsâ response time advantage for the predictable sentence items without change for non-predictable items, consistent with the previous TMS results. Furthermore, anodal stimulation enhanced the response time advantage for the predictable items, again without change in latencies for non-predictive items. We found a clear practice-based effect over 4 blocks. However, this difference was not significantly modulated by either anodal or cathodal stimulation. Our results therefore support the hypothesis that cerebellum contributes to predictive language processing, mirroring its predictive role in motor control, but we do not yet have evidence that the learning process was affected by cerebellar TDCS
Direct radiocarbon dating of fish otoliths from mulloway (Argyrosomus japonicus) and black bream (Acanthopagrus butcheri) from Long Point, Coorong, South Australia
Accelerator Mass Spectrometry (AMS) radiocarbon dates (n=20) determined on fish otoliths from mulloway (Argyrosomus japonicus) and black bream (Acanthopagrus butcheri) are reported from five sites at Long Point, Coorong, South Australia. The dates range from 2938â2529 to 326â1 cal. BP, extending the known period of occupation of Long Point. Previous dating at the sites indicated intensive occupation of the area from 2455â2134 cal. BP. Results provide a detailed local chronology for the region, contributing to a more comprehensive understanding of Aboriginal use of Ngarrindjeri lands and waters. This study validates the use of fish otoliths for radiocarbon dating and reveals how dating different materials can result in different midden chronologies
"You're more engaged when you're listening to somebody tell their story": A qualitative exploration into the mechanisms of the podcast 'menopause: unmuted' for communicating health information.
While health podcasts can be effective in reducing stigma and increasing knowledge, we know little about their mechanisms of action. This qualitative study explored the mechanisms of how women connected with the podcast 'menopause: unmuted', which presented menopause information in a storytelling format. A diverse sample of 30 women aged 40-60 years were interviewed after listening to the podcast. Interviews covered participant's views and perceptions of the stories presented. Transcripts were analyzed thematically. Two overarching themes were identified. 'Openness and authenticity' describes the value of personal stories told in an authentic way by real experts-by-experience. 'Relatability and representation' explores participants' emotional reaction to the podcast, influenced by the extent to which they identified with the stories and storytellers on the podcast. Authenticity and relatability were identified as key mechanisms through which participants connected with audio stories, consistent with Fisher's narrative theory. These findings have important implications for the application of storytelling in podcasts designed to influence health behaviors. Diverse stories representing a range of demographic characteristics and experiences are needed when creating podcasts about health information to increase listener's relatability and connection. [Abstract copyright: Copyright Š 2022 The Authors. Published by Elsevier B.V. All rights reserved.
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The Utility of Outcome Studies in Plastic Surgery
Summary: Outcome studies help provide the evidence-based science rationalizing treatment end results that factor the experience of patients and the impact on society. They improve the recognition of the shortcoming in clinical practice and provide the foundation for the development of gold standard care. With such evidence, health care practitioners can develop evidence-based justification for treatments and offer patients with superior informed consent for their treatment options. Furthermore, health care and insurance agencies can recognize improved cost-benefit options in the purpose of disease prevention and alleviation of its impact on the patient and society. Health care outcomes are ultimately measured by the treatment of disease, the reduction of symptoms, the normalization of laboratory results and physical measures, saving a life, and patient satisfaction. In this review, we outline the tools available to measure outcomes in plastic surgery and subsequently allow the objective measurements of plastic surgical conditions. Six major outcome categories are discussed: (1) functional measures; (2) preference-based measures and utility outcome scores; (3) patient satisfaction; (4) health outcomes and time; (5) other tools: patient-reported outcome measurement information system, BREAST-Q, and Tracking Operations and Outcomes for Plastic Surgeons; and (6) cost-effectiveness analysis. We use breast hypertrophy requiring breast reduction as an example throughout this review as a representative plastic surgical condition with multiple treatments available
Near and mid-infrared colours of star-forming galaxies in ELAIS fields
We present J and K-band near-infrared photometry of a sample of mid-infrared
sources detected by the Infrared Space Observatory (ISO) as part of the
European Large Area ISO-Survey (ELAIS) and study their classification and
star-forming properties. We have used the Preliminary ELAIS Catalogue for the
6.7 micron (LW2) and 15 micron (LW3) fluxes. All of the high-reliability LW2
sources and 80 per cent of the LW3 sources are identified in the near-IR survey
reaching K = 17.5 mag. The near- to mid-IR flux ratios can effectively be used
to separate stars from galaxies in mid-IR surveys. The stars detected in our
survey region are used to derive a new accurate calibration for the ELAIS
ISOCAM data in both the LW2 and LW3 filters. We show that near to mid-IR
colour-colour diagrams can be used to further classify galaxies, as well as
study star-formation. The ISOCAM ELAIS survey is found to mostly detect
strongly star-forming late-type galaxies, possibly starburst powered galaxies,
and it also picks out obscured AGN. The ELAIS galaxies yield an average mid-IR
flux ratio LW2/LW3 = 0.67 +/- 0.27. We discuss this [6.7/15] ratio as a star
formation tracer using ISO and IRAS data of a local comparison sample. We find
that the [K/15] ratio is also agood indicator of activity level in galaxies and
conclude that the drop in the [6.7/15] ratio seen in strongly star-forming
galaxies is a result of both an increase of 15 mic emission and an apparent
depletion of 6.7 mic emission. Near-IR data together with the mid-IR give the
possibility to estimate the relative amount of interstellar matter in the
galaxies.Comment: 18 pages, 15 figures; accepted for publication in MNRA
Anti-Nirvana: crime, culture and instrumentalism in the age of insecurity
âAnti-Nirvanaâ explores the relationship between consumer culture, media and criminal motivations. It has appeared consistently on the list of the top-ten most-read articles in this award-winning international journal, and it mounts a serious neo-Freudian challenge to the predominant naturalistic notion of âresistanceâ at the heart of liberal criminology and media studies. It is also cited in the Oxford Handbook of Criminology and other criminology texts as a persuasive argument in support of the theory that criminality amongst young people is strongly linked to the acquisitive values of consumerism and the images of possessive individualism that dominate mass media
The European Large Area ISO Survey II: mid-infrared extragalactic source counts
We present preliminary source counts at 6.7um and 15um from the Preliminary
Analysis of the European Large Area ISO survey, with limiting flux densities of
\~2mJy at 15um & ~1mJy at 6.7um. We separate the stellar contribution from the
extragalactic using identifications with APM sources made with the likelihood
ratio technique. We quantify the completeness & reliability of our source
extraction using (a) repeated observations over small areas, (b) cross-IDs with
stars of known spectral type, (c) detections of the PSF wings around bright
sources, (d) comparison with independent algorithms. Flux calibration at 15um
was performed using stellar IDs; the calibration does not agree with the
pre-flight estimates, probably due to effects of detector hysteresis and
photometric aperture correction. The 6.7um extragalactic counts are broadly
reproduced in the Pearson & Rowan-Robinson model, but the Franceschini et al.
(1997) model underpredicts the observed source density by ~0.5-1 dex, though
the photometry at 6.7um is still preliminary. At 15um the extragalactic counts
are in excellent agreement with the predictions of the Pearson & Rowan-Robinson
(1996), Franceschini et al. (1994), Guiderdoni et al. (1997) and the evolving
models of Xu et al. (1998), over 7 orders of magnitude in 15um flux density.
The counts agree with other estimates from the ISOCAM instrument at overlapping
flux densities (Elbaz et al. 1999), provided a consistent flux calibration is
used. Luminosity evolution at a rate of (1+z)^3, incorporating mid-IR spectral
features, provides a better fit to the 15um differential counts than (1+z)^4
density evolution. No-evolution models are excluded, and implying that below
around 10mJy at 15um the source counts become dominated by an evolving
cosmological population of dust-shrouded starbursts and/or active galaxies.Comment: MNRAS in press. 14 pages, uses BoxedEPS (included). For more
information on the ELAIS project see http://athena.ph.ic.ac.uk
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