620 research outputs found

    Heavy ion action on single cells: Cellular inactivation capability of single accelerated heavy ions

    Get PDF
    Heavy ions (HZE-particles) constitute an important part of radiation in space. Although their number is small the high amount of energy transferred by individual particles may cause severe biological effects. Their investigation requires special techniques which were tested by experiments performed at the UNILAC at the GSI (Darmstadt). Diploid yeast was used which is a suitable eucaryotic test system because of its resistance to extreme conditions like dryness and vacuum. Cells were placed on nuclear track detector foils and exposed to ions of different atomic number and energy. To assess the action of one single ion on an individual cell, track parameters and the respective colony forming abilities (CFA) were determined with the help of computer aided image analysis. There is mounting evidence that not only the amount of energy deposited along the particle path, commonly given by the LET, is of importance but also the spatial problem of energy deposition at a submicroscopical scale. It is virtually impossible to investigate track structure effects in detail with whole cell populations and (globally applied) high particle fluences. It is, therefore, necessary to detect the action of simple ions in individual cells. The results show that the biological action depends on atomic number and specific energy of the impinging ions, which can be compared with model calculations of recent track structure models

    Thermocline state change in the eastern equatorial Pacific during the late Pliocene/early Pleistocene intensification of Northern Hemisphere glaciation

    Get PDF
    The late Pliocene/early Pleistocene intensification of Northern Hemisphere glaciation (iNHG)  ∼ 2.5 million years ago (marine isotope stages, MIS, 100–96) stands out as an important tipping point in Earth's climate history, which strongly influenced oceanographic and climatic patterns including trade wind and upwelling strength in the eastern equatorial Pacific (EEP). The thermocline depth in the EEP, in turn, plays a pivotal role in the Earth's climate system: small changes in its depth associated with short-term climate phenomena such as the El Niño–Southern Oscillation can affect surface-water properties and the ocean–atmosphere exchange. However, thermocline dynamics in the EEP during the iNHG still remain unclear. While numerous studies have suggested a link between a thermocline shoaling in the EEP and Northern Hemisphere ice growth, other studies have indicated a stable thermocline depth during the iNHG; consequently, a causal relationship between thermocline dynamics and ice-sheet growth has been excluded. In light of these contradictory views, we have generated geochemical (planktic foraminiferal δ18O, δ13C and Mg&thinsp;∕&thinsp;Ca), sedimentological (sand accumulation rates) and faunal (abundance data of thermocline-dwelling foraminifera) records for Ocean Drilling Program Site 849 located in the central region of the EEP. Our records span the interval from  ∼ 2.75 to 2.4&thinsp;Ma (MIS G7–95), which is critical for understanding thermocline dynamics during the final phase of the iNHG. Our new records document a thermocline shoaling from  ∼ 2.64 to 2.55&thinsp;Ma (MIS G2–101) and a relatively shallow thermocline from  ∼ 2.55&thinsp;Ma onwards (MIS 101–95). This indicates a state change in thermocline depth at Site 849 shortly before the final phase of the iNHG. Ultimately, our data support the hypothesis that (sub-)tropical thermocline shoaling may have contributed to the development of large Northern Hemisphere ice sheets.</p

    Underperforming policy networks : the biopesticides network in the United Kingdom

    Get PDF
    Loosely integrated and incomplete policy networks have been neglected in the literature. They are important to consider in terms of understanding network underperformance. The effective delivery and formulation of policy requires networks that are not incomplete or underperforming. The biopesticides policy network in the United Kingdom is considered and its components identified with an emphasis on the lack of integration of retailers and environmental groups. The nature of the network constrains the actions of its agents and frustrates the achievement of policy goals. A study of this relatively immature policy network also allows for a focus on network formation. The state, via an external central government department, has been a key factor in the development of the network. Therefore, it is important to incorporate such factors more systematically into understandings of network formation. Feedback efforts from policy have increased interactions between productionist actors but the sphere of consumption remains insufficiently articulated

    Agency, qualia and life: connecting mind and body biologically

    Get PDF
    Many believe that a suitably programmed computer could act for its own goals and experience feelings. I challenge this view and argue that agency, mental causation and qualia are all founded in the unique, homeostatic nature of living matter. The theory was formulated for coherence with the concept of an agent, neuroscientific data and laws of physics. By this method, I infer that a successful action is homeostatic for its agent and can be caused by a feeling - which does not motivate as a force, but as a control signal. From brain research and the locality principle of physics, I surmise that qualia are a fundamental, biological form of energy generated in specialized neurons. Subjectivity is explained as thermodynamically necessary on the supposition that, by converting action potentials to feelings, the neural cells avert damage from the electrochemical pulses. In exchange for this entropic benefit, phenomenal energy is spent as and where it is produced - which precludes the objective observation of qualia

    The marine isotope stage 1–5 cryptotephra record of Tenaghi Philippon, Greece:Towards a detailed tephrostratigraphic framework for the Eastern Mediterranean region

    Get PDF
    The iconic climate archive of Tenaghi Philippon (TP), NE Greece, allows the study of short-term palaeoclimatic and environmental change throughout the past 1.3 Ma. To provide high-quality age control for detailed palaeoclimate reconstructions based on the TP archive, (crypto)tephra studies of a peat core ‘TP-2005’ have been carried out for the 0–130 ka interval. The results show that the TP basin is ideally positioned to receive tephra fall from both the Italian and Aegean Arc volcanic provinces. Two visible tephra layers, the Santorini Cape Riva/Y-2 (c. 22 ka) and the Campanian Ignimbrite (CI)/Y-5 (c. 39.8 ka) tephras, and six primary cryptotephra layers, namely the early Holocene E1 tephra from the Aeolian Islands (c. 8.3 ka), the Campanian Y-3 (c. 29 ka) and X-6 tephras (c. 109.5 ka), as well as counterpart tephras TM-18-1d (c. 40.4 ka), TM-23-11 (c. 92.4 ka) and TM-33-1a (c. 116.7 ka) from the Lago Grande di Monticchio sequence (southern Italy), were identified along with repeatedly redeposited Y-2 and CI tephra material. Bayesian modelling of the ages of seven of the primary tephra layers, 60 radiocarbon measurements and 20 palynological control points have been applied to markedly improve the chronology of the TP archive. This revised chronology constrains the age of tephra TM-18-1d to 40.90–41.66 cal ka BP (95.4% range). Several tephra layers identified in the TP record form important isochrons for correlating this archive with other terrestrial (e.g., Lago Grande di Monticchio, Sulmona Basin and Lake Ohrid) and marine (e.g., Adriatic Sea core PRAD 1-2 and Aegean Sea core LC21) palaeoclimate records in the Mediterranean region

    Evidence for the impact of the 8.2-kyBP climate event on Near Eastern early farmers.

    Get PDF
    The 8.2-thousand years B.P. event is evident in multiple proxy records across the globe, showing generally dry and cold conditions for ca. 160 years. Environmental changes around the event are mainly detected using geochemical or palynological analyses of ice cores, lacustrine, marine, and other sediments often distant from human settlements. The Late Neolithic excavated area of the archaeological site of Çatalhöyük East [Team Poznań (TP) area] was occupied for four centuries in the ninth and eighth millennia B.P., thus encompassing the 8.2-thousand years B.P. climatic event. A Bayesian analysis of 56 radiocarbon dates yielded a high-resolution chronological model comprising six building phases, with dates ranging from before 8325-8205 to 7925-7815 calibrated years (cal) B.P. Here, we correlate an onsite paleoclimate record constructed from δ2H values of lipid biomarkers preserved in pottery vessels recovered from these buildings with changes in architectural, archaeozoological, and consumption records from well-documented archaeological contexts. The overall sequence shows major changes in husbandry and consumption practices at ca. 8.2 thousand years B.P., synchronous with variations in the δ2H values of the animal fat residues. Changes in paleoclimate and archaeological records seem connected with the patterns of atmospheric precipitation during the occupation of the TP area predicted by climate modeling. Our multiproxy approach uses records derived directly from documented archaeological contexts. Through this, we provide compelling evidence for the specific impacts of the 8.2-thousand years B.P. climatic event on the economic and domestic activities of pioneer Neolithic farmers, influencing decisions relating to settlement planning and food procurement strategies
    • …
    corecore