47 research outputs found
Bilateral claw hand: An uncommon presentation of regional Guillain-Barré syndrome
We present an uncommon case of a 38-year-old man presented with bilateral subacute weakness of intrinsic hand muscles, manifesting as bilateral claw-hand, without sensory deficits and absent tendon reflexes in upper arms. Nerve conduction studies showed findings consistent with demyelinating GBS. During the fourth day of hospitalization the patient presented symmetrical distal leg weakness and was treated with intravenous immunoglobulin. © 2013 Elsevier B.V
Paraneoplastic Isaac's syndrome associated with thymoma and anti-neuronal nuclear antibodies 1
Extracranial venous hemodynamics in multiple sclerosis A case-control study
Objectives: A chronic state of impaired cerebral and cervical venous
drainage, termed chronic cerebrospinal venous insufficiency (CCSVI), has
recently been implicated in the pathogenesis of multiple sclerosis (MS).
We performed a color-coded Doppler sonography case-control study to
externally validate the CCSVI criteria.
Methods: We prospectively evaluated consecutive patients with clinically
definite MS and healthy volunteers using extracranial and transcranial
color-coded Doppler sonography. The recently developed neurosonology
criteria for CCSVI detection were used for interpretation of ultrasound
assessments. The presence of venous reflux in cervical veins was
assessed both in the sitting and upright position during a short period
of apnea and after Valsalva maneuver.
Results: We recruited 42 patients with MS (mean age 39 +/- 11 years, 17
men) and 43 control individuals (mean age 38 +/- 12 years, 16 men). Very
good/excellent intrarater and interrater agreement (kappa values
0.82-1.00) was documented in 3 out of 5 CCSVI criteria. There was no
evidence of stenosis or nondetectable Doppler flow in cervical veins in
patients and controls. Reflux in internal jugular vein (IJV) was
documented in 1 patient (2%) and 1 control subject (2%), both in
sitting and supine posture during apnea. After performing Valsalva
maneuver, we documented the presence of IJV valve incompetence in 3
patients with MS (7%) and 4 healthy volunteers (9%; p > 0.999).
Conclusions: With established reproducibility of venous ultrasound
testing, our data argue against CCSVI as the underlying mechanism of MS.
Without further independent validation of CCSVI, potentially dangerous
endovascular procedures, proposed as novel therapy for MS, should not be
performed outside controlled clinical trials. Neurology (R) 2011; 77:
1241-124
Intravenous thrombolysis for acute ischemic stroke occurring during hospitalization for transient ischemic attack
Background: There are limited data regarding the use of intravenous thrombolysis in patients who experienced acute ischemic symptoms during their hospitalization for prior transient ischemic attack. Aim: We sought to prospectively evaluate the safety and efficacy of intravenous thrombolysis for the treatment of acute ischemic stroke occurring during hospitalization for transient ischemic attack in an international, multicenter study. Methods: Consecutive patients with acute ischemic stroke that occurred during hospitalization for prior transient ischemic attack were treated with intravenous thrombolysis in five tertiary-care stroke centers. Early arterial recanalization was determined by transcranial Doppler at the end of recombinant tissue plasminogen activator infusion using previously validated criteria. Symptomatic intracranial hemorrhage complicating intravenous thrombolysis was evaluated using the National Institute of Neurological Disorders and Stroke Recombinant Tissue Plasminogen Activator Stroke Study definition. Functional independence at three-months was defined as Modified Rankin Scale score of 0-2. Results: Systemic recombinant tissue plasminogen activator infusion (median onset-to-treatment time 70mins, interquartile range 50-150) was given in 25 consecutive patients (mean age 66±10 years) who developed acute ischemic stroke symptoms (median National Institutes of Health Stroke Scale score 10 points; interquartile range 8-14) during hospitalization for prior transient ischemic attack (median ABCD2 score 5 points; median time-to-symptom recurrence 24h, interquartile range 24-48). No symptomatic intracranial hemorrhage (0%; 95% confidence interval 0-12%) was documented. Early complete recanalization occurred in 64% of patients (95% confidence interval 44-80%), and 84% (95% confidence interval 65-94%) achieved three-month functional independence. The rate of three-month functional independence was higher in patients treated with intravenous tissue plasminogen activator within 90mins from symptom onset compared with those with onset-to-treatment time>90mins (81% vs. 33%; P=0·031). Conclusions: Intravenous thrombolysis for symptoms of acute ischemic stroke occurring after hospitalization for transient ischemic attack appears to be safe. These pilot data support resetting the clock if new symptoms recur shortly after transient ischemic attack. © 2013 World Stroke Organization
Influence of sleep disturbance on quality of life of patients with epilepsy
SummaryThe frequency of sleep disturbances in patients with epilepsy and their impact on quality of life (QoL) have been documented in a few reports, and the results are conflicting. We identified 124 consecutive epilepsy out-patients who visited the epilepsy out-patient clinics at the University Hospital of Alexandroupolis, the AHEPA Hospital in Thessaloniki and the Aeginitio Hospital in Athens. We measured excessive daytime sleepiness (EDS) with the Epworth Sleepiness Scale (ESS), obstructive sleep apnea (OSA) with the Sleep Apnea scale of the Sleep Disorders Questionnaire (SA-SDQ), and insomnia with the Athens Insomnia Scale (AIS). We evaluated quality of life by the Quality of Life in Epilepsy Inventory (QOLIE-31). EDS was found in 16.9% (21/124) of epileptic patients, OSA in 28.2% (35/124), and insomnia in 24.6% (30/122). In multivariate analysis, we found that insomnia was an independent negative factor for Total score (p<0.001), Overall QoL (p=0.002), Emotional well-being (p<0.001), Energy/fatigue (p<0.001), Cognitive functioning (p=0.04) and Social functioning (p=0.03), and OSA only for Cognitive functioning (p=0.01). According to our findings, EDS, OSA, and insomnia are frequent in epileptic patients. Epileptic patients with sleep disturbance, mainly insomnia, have significant QoL impairment
Intravenous thrombolysis for acute ischemic stroke occurring during hospitalization for transient ischemic attack
10.1111/ijs.12125International Journal of Stroke94413-41
Click Evoked Neurogenic Vestibular Potentials (NVESTEPs): A Method of Assessing the Function of the Vestibular System
To obtain neurogenic vestibular evoked potentials (NVESTEPs) with surface scalp recording using high intensity auditory clicks. The same stimulus is used in myogenic vestibular evoked potentials which has been shown to evoke potentials in the vestibular division of the vestibulocochlear nerve.
A whole head recording with surface EEG electrodes was performed using high intensity clicks in one normal volunteer to determine the best recording position for vestibular evoked potentials. The results were compared to responses at moderate click intensities used for brainstem auditory evoked potentials (BAEPs). The difference in the location of the two responses on the scalp was assumed to be from the vestibular system.
Responses specific to the high intensity clicks were best obtained in the parietal areas, with no reproducible responses obtained in the same area with moderate intensity clicks normally used in BAEPs. Recordings in neurologically normal volunteers showed a consistent response with a negative polarity at around 3 ms, which we therefore called N3. Two case studies are presented. The first case is a patient with unilateral sensorineural hearing loss with NVESTEPs present, suggesting that NVESTEPs is not a cochlear response. The second case is a patient with multiple sclerosis with demyelinating lesions in the pons and an unobtainable NVESTEP response.
NVESTEPs is a possible new diagnostic technique that may be specific for the vestibular pathway. It has potential use in patients with symptoms of dizziness, subclinical symptoms in multiple sclerosis, and in disorders specific for the vestibular nerve