Energy-aware Load Balancing Policies for the Cloud Ecosystem

The energy consumption of computer and communication systems does not scale linearly with the workload. A system uses a significant amount of energy even when idle or lightly loaded. A widely reported solution to resource management in large data centers is to concentrate the load on a subset of servers and, whenever possible, switch the rest of the servers to one of the possible sleep states. We propose a reformulation of the traditional concept of load balancing aiming to optimize the energy consumption of a large-scale system: {\it distribute the workload evenly to the smallest set of servers operating at an optimal energy level, while observing QoS constraints, such as the response time.} Our model applies to clustered systems; the model also requires that the demand for system resources to increase at a bounded rate in each reallocation interval. In this paper we report the VM migration costs for application scaling.Comment: 10 Page

Clustering Algorithms for Scale-free Networks and Applications to Cloud Resource Management

In this paper we introduce algorithms for the construction of scale-free networks and for clustering around the nerve centers, nodes with a high connectivity in a scale-free networks. We argue that such overlay networks could support self-organization in a complex system like a cloud computing infrastructure and allow the implementation of optimal resource management policies.Comment: 14 pages, 8 Figurs, Journa

Coalition Formation and Combinatorial Auctions; Applications to Self-organization and Self-management in Utility Computing

In this paper we propose a two-stage protocol for resource management in a hierarchically organized cloud. The first stage exploits spatial locality for the formation of coalitions of supply agents; the second stage, a combinatorial auction, is based on a modified proxy-based clock algorithm and has two phases, a clock phase and a proxy phase. The clock phase supports price discovery; in the second phase a proxy conducts multiple rounds of a combinatorial auction for the package of services requested by each client. The protocol strikes a balance between low-cost services for cloud clients and a decent profit for the service providers. We also report the results of an empirical investigation of the combinatorial auction stage of the protocol.Comment: 14 page

Bid-Centric Cloud Service Provisioning

Bid-centric service descriptions have the potential to offer a new cloud service provisioning model that promotes portability, diversity of choice and differentiation between providers. A bid matching model based on requirements and capabilities is presented that provides the basis for such an approach. In order to facilitate the bidding process, tenders should be specified as abstractly as possible so that the solution space is not needlessly restricted. To this end, we describe how partial TOSCA service descriptions allow for a range of diverse solutions to be proposed by multiple providers in response to tenders. Rather than adopting a lowest common denominator approach, true portability should allow for the relative strengths and differentiating features of cloud service providers to be applied to bids. With this in mind, we describe how TOSCA service descriptions could be augmented with additional information in order to facilitate heterogeneity in proposed solutions, such as the use of coprocessors and provider-specific services

Dyslexia and Comorbid Dyscalculia: rate of comorbidity and underlying cognitive and learning profile

PURPOSE OF THE STUDY. Children diagnosed with a specific learning disorder (SLD) have four to five times higher chances of developing a comorbid condition. In particular, the high prevalence of comorbid dyscalculia (MD) in children with dyslexia (RD) has been documented. Nevertheless, the exact rate of MD comorbidity and the causes underlying the overlap remain unclear since most research has focused on studying them in isolation. Given the relevance of early identification and evidence-based interventions for further compensation of SLD, there is a need for studies on this matter. The study intended to fill this gap. METHOD. The study was a secondary data analysis of the standardised test scores of 215 neuropsychological assessments administered to grade 1 to 3 schoolchildren in Argentina who had a prior diagnosis of RD. For the purposes of the study, they were classified into 2 groups (RD only and comorbid RDMD). Scores were analyzed using SPSS Statistics to (i) explore the rate of MD comorbidity in children with RD; (ii) contrast the cognitive and learning profiles of the RD and the RDMD group; and (iii) assess the predictive value of each cognitive factor to the development of the RDMD comorbidity. RESULTS AND CONCLUSION. The study found that children with RD developed RDMD at a frequency of 33.5%. There was a significant difference in the two groups' learning and cognitive factors scores, with the comorbid group worst affected in all domains. Among these, verbal working memory, spatial skills, semantic long-term memory and phonological awareness were the most sensitive predictors; together they could account for 35% of the MD comorbidity. These findings are evidence of the high incidence of MD comorbidity in the population with RD and highlight the predictive value of specific cognitive markers

HOW FAST α PARTICLES ARE EMITTED IN "MASSIVE TRANSFER" REACTIONS ?

No abstract availabl

2D chiral structures in quinoline mixed Langmuir monolayers.

Chirality at interfaces is a relevant topic in nanoscience, as well as a key point for prebiotic chemistry. Mixed Langmuir monolayers, composed of the anionic phospholipid dimyristoyl phosphatidic acid (DMPA) and the cationic amphiphilic quinoline derivative 2-methyl-1-octadecylquinoline (MQ) have been built at the air-water interface. Both DMPA and MQ molecules are miscible, thus the equimolar mixture yields homogeneous monolayers completely. Chiral domains have been formed by this monolayer and observed in situ by Brewster angle microscopy (BAM). These chiral domains display a large array of shapes and sizes. The chirality of the monolayers has been confirmed by circular dichroism spectroscopy. The ordered aggregation of the quinoline group into large chiral supramolecular structures is proposed as the molecular origin of the observed chirality. Theoretical simulations using molecular mechanics confirm the strong trend of the quinoline group to form chiral aggregates. The great diversity in the size and shape of the chiral domains has been found to be strongly influenced by the competition between two nuclei growth mechanisms. An experimental procedure allowing a minimized growth through one of these mechanism is proposed, achieving a homogeneous distribution of ring-shaped domains. An overshoot in the pi-A isotherms of this mixed monolayer appears at an intermediate surface pressure. This overshoot is interpreted as being due to the large difference between the surface pressure which starts the nuclei formation, pi(crit) and the superficial pressure in which the nuclei can grow, pi(e). The rather small pi(e) value compared to pi(crit) observed for this system must be attributed to the molecular interactions involved in the mixed monolayer, which facilitate the incorporation of molecules in preformed nuclei

Genetic variation in hippocampal microRNA expression differences in C57BL/6 J X DBA/2 J (BXD) recombinant inbred mouse strains

miRNAs are short single-stranded non-coding RNAs involved in post-transcriptional gene regulation that play a major role in normal biological functions and diseases. Little is currently known about how expression of miRNAs is regulated. We surveyed variation in miRNA abundance in the hippocampus of mouse inbred strains, allowing us to take a genetic approach to the study of miRNA regulation, which is novel for miRNAs. The BXD recombinant inbred panel is a very well characterized genetic reference panel which allows quantitative trait locus (QTL) analysis of miRNA abundance and detection of correlates in a large store of brain and behavioural phenotypes.|We found five suggestive trans QTLs for the regulation of miRNAs investigated. Further analysis of these QTLs revealed two genes, Tnik and Phf17, under the miR-212 regulatory QTLs, whose expression levels were significantly correlated with miR-212 expression. We found that miR-212 expression is correlated with cocaine-related behaviour, consistent with a reported role for this miRNA in the control of cocaine consumption. miR-31 is correlated with anxiety and alcohol related behaviours. KEGG pathway analysis of each miRNA's expression correlates revealed enrichment of pathways including MAP kinase, cancer, long-term potentiation, axonal guidance and WNT signalling.|The BXD reference panel allowed us to establish genetic regulation and characterize biological function of specific miRNAs. QTL analysis enabled detection of genetic loci that regulate the expression of these miRNAs. eQTLs that regulate miRNA abundance are a new mechanism by which genetic variation influences brain and behaviour. Analysis of one of these QTLs revealed a gene, Tnik, which may regulate the expression of a miRNA, a molecular pathway and a behavioural phenotype. Evidence of genetic covariation of miR-212 abundance and cocaine related behaviours is strongly supported by previous functional studies, demonstrating the value of this approach for discovery of new functional roles and downstream processes regulated by miRNA