A PIV comparison of the flow field and wall shear stress in rigid and compliant models of healthy carotid arteries

Certain systems relevant to circulatory disease have walls which are neither rigid nor static, for example, the coronary arteries, the carotid artery and the heart chambers. In vitro modeling allows the fluid mechanics of the circulatory system to be studied without the ethical and safety issues associated with animal and human experiments. Computational methods in which the equations are coupled governing the flow and the elastic walls are maturing. Currently there is a lack of experimental data in compliant arterial systems to validate the numerical predictions. Previous experimental work has commonly used rigid wall boundaries, ignoring the effect of wall compliance. Particle Image Velocimetry is used to provide a direct comparison of both the flow field and wall shear stress (WSS) observed in experimental phantoms of rigid and compliant geometries representing an idealized common carotid artery. The input flow waveform and the mechanical response of the phantom are physiologically realistic. The results show that compliance affects the velocity profile within the artery. A rigid boundary causes severe overestimation of the peak WSS with a maximum relative difference of 61% occurring; showing compliance protects the artery from exposure to high magnitude WSS. This is important when trying to understand the development of diseases like atherosclerosis. The maximum, minimum and time averaged WSS in the rigid geometry was 2.3, 0.51 and 1.03Pa and in the compliant geometry 1.4, 0.58 and 0.84Pa, respectively

Leptonic decay constants f_Ds and f_D in three flavor lattice QCD

We determine the leptonic decay constants in three flavor unquenched lattice QCD. We use O(a^2)-improved staggered light quarks and O(a)-improved charm quarks in the Fermilab heavy quark formalism. Our preliminary results, based upon an analysis at a single lattice spacing, are f_Ds = 263(+5-9)(+/-24) MeV and f_D = 225(+11-13)(+/-21) MeV. In each case, the first reported error is statistical while the is the combined systematic uncertainty.Comment: Talk presented at Lattice2004(heavy), Fermilab, June 21-26, 2004. 3 pages, 2 figure

Visual stimulus parameters seriously compromise the measurement of approximate number system acuity and comparative effects between adults and children

It has been suggested that a simple non-symbolic magnitude comparison task is sufficient to measure the acuity of a putative Approximate Number System (ANS). A proposed measure of the ANS, the so-called “internal Weber fraction” (w), would provide a clear measure of ANS acuity. However, ANS studies have never presented adequate evidence that visual stimulus parameters did not compromise measurements of w to such extent that w is actually driven by visual instead of numerical processes. We therefore investigated this question by testing non-symbolic magnitude discrimination in seven-year-old children and adults. We manipulated/controlled visual parameters in a more stringent manner than usual. As a consequence of these controls, in some trials numerical cues correlated positively with number while in others they correlated negatively with number. This congruency effect strongly correlated with w, which means that congruency effects were probably driving effects in w. Consequently, in both adults and children congruency had a major impact on the fit of the model underlying the computation of w. Furthermore, children showed larger congruency effects than adults. This suggests that ANS tasks are seriously compromised by the visual stimulus parameters, which cannot be controlled. Hence, they are not pure measures of the ANS and some putative w or ratio effect differences between children and adults in previous ANS studies may be due to the differential influence of the visual stimulus parameters in children and adults. In addition, because the resolution of congruency effects relies on inhibitory (interference suppression) function, some previous ANS findings were probably influenced by the developmental state of inhibitory processes especially when comparing children with developmental dyscalculia and typically developing children

Geomorphic Constraints on Listric Thrust Faulting: Implications for Active Deformation in the Mackenzie Basin, South Island, New Zealand

Deformed fluvial terraces preserved over active thrust-related folds record the kinematics of folding as fault slip accumulates on the underlying thrust. In the Mackenzie Basin of southern New Zealand, the kinematics revealed by folded fluvial terraces along the active Ostler and Irishman Creek fault zones are inconsistent with traditional models for thrust-related folding in which spatially uniform rock uplift typically occurs over planar fault ramps. Instead, warped and tilted terraces in the Mackenzie are characterized by broad, continuous backlimbs and abrupt forelimbs and suggest folding through progressive limb rotation. By relating this pattern of surface deformation to the underlying thrust with a newly developed, simple geometric and kinematic model, we interpret both faults as listric thrusts rooted at depth into gently dipping planar fault ramps. Constraints on the model from detailed topographic surveying of deformed terraces, ground-penetrating radar over active fault scarps, and luminescence dating of terrace surfaces suggest slip rates for the Ostler and Irishman Creek faults of ~1.1– 1.7 mm/yr and~0.5–0.7 mm/yr, respectively. The predicted depth of listric faulting for the Ostler fault (0.70 +0.1-0.2 km) and the Irishman Creek fault (1.3+0.1-0.5 km) generally agrees with geophysical estimates of basin depth in the Mackenzie and suggests control of preexisting basin architecture on the geometry of active thrusting. Despite the potential effects of changes in fault curvature and hanging wall internal deformation, the methodology presented here provides a simple tool for approximating the kinematics of surface deformation associated with slip along listric, or curviplanar, thrust faults

Recent results from lattice calculations

Recent results from lattice QCD calculations relevant to particle physics phenomenology are reviewed. They include the calculations of strong coupling constant, quark masses, kaon matrix elements, and D and B meson matrix elements. Special emphasis is on the recent progress in the simulations including dynamical quarks.Comment: 13 pages, 8 figures, plenary talk at the 32nd International Conference on High-Energy Physics (ICHEP 2004), August 16-22, 2004, Beijing, Chin

Design and Fabrication of a 1 m Model of the 70 mm Bore Twin Aperture Superconducting Quadrupole for the LHC Insertions

For reasons of geometrical acceptance, 70 mm bore twin aperture quadrupoles are required in the LHC insertions. For an operating gradient of 160 T/m at 4.5 K, a design based on a four layer coil wound from two graded 8.2 mm NbTi conductors has been developed. Three 1 m single aperture quadrupoles of this design have been built and successfully tested. Thereafter, the magnets have been disassembled and the coils re-collared using self-supporting collars. In this paper, we describe the design features of the twin aperture quadrupole, and report on the initial collaring tests and procedures for collaring and final assembly of the 1 m magnet

Thrombocytosis and abnormal liver enzymes:A trigger for investigation of underlying malignancy

BackgroundThrombocytosis is often an incidental finding in primary care with a range of causes. Despite evidence of a strong association between thrombocytosis and malignancy, guidelines for investigating thrombocytosis in the absence of red flag symptoms remain unclear. A novel automated system of laboratory analysis, intelligent Liver Function Testing (iLFT), launched in Tayside in 2018 and has identified a patient group with thrombocytosis and abnormal liver test (LFT) results. This study analysed the outcome of these patients and investigated the use of thrombocytosis combined with LFTs in predicting risk of cancer.Methods and findingsBetween August 2018 and August 2020, 6792 patients underwent iLFT, with 246 found to have both thrombocytosis and at least one abnormal LFT. A random case-matched control group of 492 iLFT patients with normal platelet count and at least one abnormal LFT was created. 7.7% (95% CI 4.7-11.8%) of patients with thrombocytosis had cancer compared to 2.0% (1.0-3.7%) of controls. Patients ConclusionsThese findings suggest a substantial increased risk of cancer in patients with thrombocytosis and raised ALP. This could be developed as an adjunct to current investigation algorithms, highlighting high-risk patients and prompting further investigation (such as computed tomography scans) where indicated

Prospects for the Bc Studies at LHCb

We discuss the motivations and perspectives for the studies of the mesons of the (bc) family at LHCb. The description of production and decays at LHC energies is given in details. The event yields, detection efficiencies, and background conditions for several Bc decay modes at LHCb are estimated.Comment: 20 pages, 5 eps-figure

Charm as a domain wall fermion in quenched lattice QCD

We report a study describing the charm quark by a domain-wall fermion (DWF) in lattice quantum chromodynamics (QCD). Our study uses a quenched gauge ensemble with the DBW2 rectangle-improved gauge action at a lattice cutoff of $a^{-1} \sim 3$ GeV. We calculate masses of heavy-light (charmed) and heavy-heavy (charmonium) mesons with spin-parity $J^P = 0^\mp$ and $1^\mp$, leptonic decay constants of the charmed pseudoscalar mesons ($D$ and $D_s$), and the $D^0$-$\bar{D^0}$ mixing parameter. The charm quark mass is found to be $m^{\bar{\rm MS}}_{c}(m_{c})=1.24(1)(18)$ GeV. The mass splittings in charmed-meson parity partners $\Delta_{q,J=0}$ and $\Delta_{q, J=1}$ are degenerate within statistical errors, in accord with experiment, and they satisfy a relation $\Delta_{q=ud, J} > \Delta_{q=s, J}$, also consistent with experiment. A C-odd axial vector charmonium state, $h_c), lies 22(11) MeV above the$\chi_{c1}$meson, or$m_{h_{c}} = 3533(11)_{\rm stat.}$MeV using the experimental$\chi_{c1}) mass. However, in this regard, we emphasize significant discrepancies in the calculation of hyperfine splittings on the lattice. The leptonic decay constants of $D$ and $D_s$ mesons are found to be $f_D=232(7)_{\rm stat.}(^{+6}_{-0})_{\rm chiral}(11)_{\rm syst.}$ MeV and $f_{D_s}/f_{D} = 1.05(2)_{\rm stat.}(^{+0}_{-2})_{\rm chiral}(2)_{\rm syst.}$, where the first error is statistical, the second a systematic due to chiral extrapolation and the third error combination of other known systematics. The $D^0$-$\bar{D^0}$ mixing bag parameter, which enters the $\Delta C = 2$ transition amplitude, is found to be $B_D(2{GeV})=0.845(24)_{\rm stat.}(^{+24}_{-6})_{\rm chiral}(105)_{\rm syst.}$.Comment: 49 pages, 15 figure