Application of optimization techniques to vehicle design: A review

The work that has been done in the last decade or so in the application of optimization techniques to vehicle design is discussed. Much of the work reviewed deals with the design of body or suspension (chassis) components for reduced weight. Also reviewed are studies dealing with system optimization problems for improved functional performance, such as ride or handling. In reviewing the work on the use of optimization techniques, one notes the transition from the rare mention of the methods in the 70's to an increased effort in the early 80's. Efficient and convenient optimization and analysis tools still need to be developed so that they can be regularly applied in the early design stage of the vehicle development cycle to be most effective. Based on the reported applications, an attempt is made to assess the potential for automotive application of optimization techniques. The major issue involved remains the creation of quantifiable means of analysis to be used in vehicle design. The conventional process of vehicle design still contains much experience-based input because it has not yet proven possible to quantify all important constraints. This restraint on the part of the analysis will continue to be a major limiting factor in application of optimization to vehicle design

A Study of the Structure of the Transition Metal Hydryls Final Report

Crystal and molecular structures of transition rhodium and lithium hydril

Seismic reflection data reveal the 3D structure of the newly discovered Exmouth Dyke Swarm, offshore NW Australia

Dyke swarms are common on Earth and other planetary bodies, comprising arrays of dykes that can extend laterally for tens to thousands of kilometres. The vast extent of such dyke swarms, and their presumed rapid emplacement, means they can significantly influence a variety of planetary processes, including continental break-up, crustal extension, resource accumulation, and volcanism. Determining the mechanisms driving dyke swarm emplacement is thus critical to a range of Earth Science disciplines. However, unravelling dyke swarm emplacement mechanics relies on constraining their 3D structure, which is difficult given we typically cannot access their subsurface geometry at a sufficiently high enough resolution. Here we use high-quality seismic reflection data to identify and examine the 3D geometry of the newly discovered Exmouth Dyke Swarm, and associated structures (i.e. dyke-induced normal faults and pit craters). Dykes are expressed in our seismic reflection data as ∼335–68 m wide, vertical zones of disruption (VZD), in which stratal reflections are dimmed and/or deflected from sub-horizontal. Borehole data reveal one ∼130 m wide VZD corresponds to an ∼18 m thick, mafic dyke, highlighting that the true geometry of the inferred dykes may not be fully captured by their seismic expression. The Late Jurassic dyke swarm is located on the Gascoyne Margin, offshore NW Australia, and contains numerous dykes that extend laterally for > 170 km, potentially up to > 500 km, with spacings typically < 10 km. Although limitations in data quality and resolution restrict mapping of the dykes at depth, our data show that they likely have heights of at least 3.5 km. The mapped dykes are distributed radially across a ∼39∘ wide arc centred on the Cuvier Margin; we infer that this focal area marks the source of the dyke swarm. We demonstrate that seismic reflection data provide unique opportunities to map and quantify dyke swarms in 3D. Because of this, we can now (i) recognise dyke swarms across continental margins worldwide and incorporate them into models of basin evolution and fluid flow, (ii) test previous models and hypotheses concerning the 3D structure of dyke swarms, (iii) reveal how dyke-induced normal faults and pit craters relate to dyking, and (iv) unravel how dyking translates into surface deformation

Public views on the donation and use of human biological samples in biomedical research: a mixed methods study

Objective A mixed methods study exploring the UK general public's willingness to donate human biosamples (HBSs) for biomedical research.&lt;p&gt;&lt;/p&gt; Setting Cross-sectional focus groups followed by an online survey.&lt;p&gt;&lt;/p&gt; Participants Twelve focus groups (81 participants) selectively sampled to reflect a range of demographic groups; 1110 survey responders recruited through a stratified sampling method with quotas set on sex, age, geographical location, socioeconomic group and ethnicity.&lt;p&gt;&lt;/p&gt; Main outcome measures (1) Identify participants’ willingness to donate HBSs for biomedical research, (2) explore acceptability towards donating different types of HBSs in various settings and (3) explore preferences regarding use and access to HBSs.&lt;p&gt;&lt;/p&gt; Results 87% of survey participants thought donation of HBSs was important and 75% wanted to be asked to donate in general. Responders who self-reported having some or good knowledge of the medical research process were significantly more likely to want to donate (p&#60;0.001). Reasons why focus group participants saw donation as important included: it was a good way of reciprocating for the medical treatment received; it was an important way of developing drugs and treatments; residual tissue would otherwise go to waste and they or their family members might benefit. The most controversial types of HBSs to donate included: brain post mortem (29% would donate), eyes post mortem (35%), embryos (44%), spare eggs (48%) and sperm (58%). Regarding the use of samples, there were concerns over animal research (34%), research conducted outside the UK (35%), and research conducted by pharmaceutical companies (56%), although education and discussion were found to alleviate such concerns.&lt;p&gt;&lt;/p&gt; Conclusions There is a high level of public support and willingness to donate HBSs for biomedical research. Underlying concerns exist regarding the use of certain types of HBSs and conditions under which they are used. Improved education and more controlled forms of consent for sensitive samples may mitigate such concerns.&lt;p&gt;&lt;/p&gt

Steroids in Pediatric Kidney Transplantation: A Balancing Act in Progress

Received 23 July 2009, revised 29 September 2009 and accepted for publication 02 October 2009Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/78710/1/j.1600-6143.2009.02923.x.pd

The Stratigraphic Record of Pre-breakup Geodynamics: Evidence from the Barrow Delta, offshore Northwest Australia

The structural and stratigraphic evolution of rift basins and passive margins has been widely studied, with many analyses demonstrating that delta systems can provide important records of post-rift geodynamic processes. However, the apparent lack of ancient syn-breakup delta systems and the paucity of seismic imaging across continent-ocean boundaries means the transition from continental rifting to oceanic spreading remains poorly understood. The Early Cretaceous Barrow Group of the North Carnarvon Basin, offshore NW Australia was a major deltaic system that formed during the latter stages of continental rifting, and represents a rich sedimentary archive, documenting uplift, subsidence and erosion of the margin. We use a regional database of 2D and 3D seismic and well data to constrain the internal architecture of the Barrow Group. Our results highlight three major depocentres: the Exmouth and Barrow sub-basins, and southern Exmouth Plateau. Over-compaction of pre-Cretaceous sedimentary rocks in the South Carnarvon Basin, and pervasive reworking of Permian and Triassic palynomorphs in the offshore Barrow Group, suggests that the onshore South Carnarvon Basin originally contained a thicker sedimentary succession, which was uplifted and eroded prior to breakup. Backstripping of sedimentary successions encountered in wells in the Exmouth Plateau depocentre indicate anomalously rapid tectonic subsidence (≤0.24 mm yr-1) accommodated Barrow Group deposition, despite evidence for minimal, contemporaneous upper crustal extension. Our results suggest that classic models of uniform extension cannot account for the observations of uplift and subsidence in the North Carnarvon Basin, and may indicate a period of depth-dependent extension or dynamic topography preceding breakup