Continuous animal exposure to dichloromethane

Continuous exposures of dogs, monkeys, rats and mice to 5000 ppm and 1000 ppm of dichloromethane vapor (CH2Cl2) produced severe toxic effects on dogs, rats and mice. Dogs died after 3 weeks exposure to 1000 ppm and after 6 weeks exposure to 5000 ppm. Thirty percent of the mice also succumbed during four weeks exposure to 5000 ppm CH2Cl2. Although rats survived 14 weeks exposure to 5000 ppm, they experienced subnormal weight gains. Significant gross and histopathological hepatic lesions were noted in all 3 species at death or experimental termination in 14 weeks. In addition, rats showed abnormal kidney histopathology. Fat stains disclosed mild fatty increase in monkey livers after 14 weeks exposure to 1000 ppm CH2Cl2

Effect of 90-day continuous exposure to methylisobutylketone on dogs, monkeys and rats

Continuous exposure of rats, dogs and monkeys to 410 mg/cu M methylisobutylketone vapor (MIBK) was conducted to evaluate the provisional spacecraft exposure limit of 20 ppm established by the Space Science Board in 1968. The exposure, conducted in a simulated space cabin environment, did not produce any measurable changes in dogs or monkeys. Rats developed hyaline droplet nephrosis within 2 weeks of exposure which was reversible upon removal from the MIBK even after 90 days. The data obtained indicated that the 60-minute emergency exposure limit of 100 ppm and the 90- and 1000-day provisional limits as established by the Space Science Board contain a wide margin of safety

Effects of inhalation of Freon 113 on laboratory animals

Four monkeys, 8 dogs, 40 mice, and 50 rats were exposed continuously to 2000 ppm Freon 113 in a Thomas Dome for 14 days. This exposure produced no mortalities nor adverse symptomology. There were no significant alterations in hematological values, clinical chemistries, electroencephalographic findings, body weights, or organ to body weight ratios. The effect of 2% Freon 113 on nicotinic transmission through the stellate ganglion of the spinal dog was also evaluated. The exposure induced a reduction in nicotinic transmission comparable to 2% halothane

A study of the biological effect of continuous inhalation exposure of 1, 1, 1-trichloroethene (methyl chloroform) on animals

The effects of continuous exposure to 1,1,1-trichloroethane on hepatic morphology and function are evaluated and compared with those produced by methylene chloride (dichloromethane) to determine environmental concentrations of each compound that would produce a similar biological response, i.e., a comparable increase in liver triglycerides over control levels. Experimental findings on mice, rats, dogs, and monkeys indicate that the pathological alternations observed with 1,1,1-trichloroethane are similar to those observed with dichloromethane except for different time courses of the effects and different degrees of recovery. A ten fold greater atmospheric concentration of 1,1,1-trichloroethane is required to produce the minimal liver changes found at 100 ppm dichloromethane

Vision screening in children:a retrospective study of social and demographic factors with regard to visual outcomes

BACKGROUND: Amblyopia and its risk factors have been demonstrated to be more common among children from low socioeconomic backgrounds. We sought to investigate this association in a region with orthoptic-delivered screening and whole population coverage, and to also examine the association of the Health Plan Indicator (HPI) with screening outcome. METHODS: Screening examination outcomes, postcodes and HPIs were extracted from the community child health database for every child who underwent preschool vision screening between March 2010 and February 2011 Tayside. We obtained the Scottish Index of Multiple Deprivation score for every child as a measure of area-based deprivation. We assessed the vulnerability/needs of the individual family through the HPI—‘Core’ (children and families receiving universal health visiting service), ‘Additional’ (receiving additional health/social support) and ‘Intensive’ (receiving high levels of support). The outcomes from follow-up examinations for those who failed screening were extracted from the orthoptic department database. RESULTS: 4365 children were screened during the year 2010–2011 of whom 523 (11.9%) failed. The odds of children from the least deprived socioeconomic group passing the visual screening test was 1.4 times higher than those from the most deprived socioeconomic group (OR 1.4, 95% CI 1.07 to 1.89, p=0.01). The odds of a child from a family assigned as ‘Intensive’ failing the preschool visual screening test was three times greater than the odds of a child from a family assigned as ‘Core’ (OR 3.59, 95% CI 1.6 to 7.8, p=0.001). CONCLUSIONS: We found that children from the most deprived backgrounds and those from unstable homes were more likely to fail preschool vision screening

Rapid prototyping and validation of FS-FBMC dynamic spectrum radio with simulink and ZynqSDR

This paper presents the research carried out in developing and targeting a novel real-time Dynamic Spectrum Access (DSA) Frequency Spread Filter Bank Multicarrier (FS-FBMC) transmitter prototype to programmable ‘ZynqSDR’ Software Defined Radio (SDR) hardware, and introduces a series of experiments used to validate the design’s ‘cognitive’ DSA capabilities. This transmitter is a proof of concept, that uses DSA techniques to enable Secondary Users (SUs) to access the band traditionally used for FM Radio broadcasting (88-108 MHz), and establish data communication channels in vacant parts of the FM Radio Primary User (PU) spectrum using a multicarrier modulation scheme with a Non Contiguous (NC) channel mask. Once implemented on the hardware, the transmitter is subjected to various FM Radio environments sampled from around Central Scotland, and it is demonstrated that it can dynamically adapt its NC transmitter mask in real time to protect the FM Radio signals it detects. A video is presented of this dynamic on-hardware spectral reconfiguration, and the reader is encouraged to view the video to appreciate the responsiveness of the design. An investigation into potential FBMC guardband sizes is carried out, with initial findings indicating a guardband of 200 kHz (either side of an FM Radio station) is required in order to prevent interference with the PUs. This paper also demonstrates the capabilities of the MATLAB®/ Simulink ZynqSDR workflow, and provides a case study and reference design that we feel other researchers working in this field can benefit from

Acute inhalation toxicology and proposed emergency exposure limits of nitrogen trifluoride,

Acute exposures of rats, mice, dogs and monkeys to nitrogen trifluoride have been carried out and median lethal concentrations were determined for rats and mice. Confirmative evidence was obtained that the immediate effects of acute exposure are caused by extensive methemoglobin formation and resulting anoxia. Dogs surviving exposure to 9600 ppm for 60 min exhibit a Heinz body anemia with red blood cell count, hemoglobin and hematocrit decreasing 33% to minimum values by the end of the second week postexposure. Recovery of hematologic values to preexposure levels is attained in 40 days. In dogs, the anemia caused by a dose level of 120,000 ppm-min is severe enough to invalidate that dose as an emergency exposure limit (EEL). At 30,000 ppm-min, however, no detectable anemia occurs, and no other toxic effects are discernible. The results of experiments conducted at subacute levels justify recommending an upward revision of the EEL to 30,000 ppm-min from the proposed National Academy of Science, National Research Council value of 3000 ppm-min.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/33816/1/0000072.pd