Predictions for the unitarity triangle angles in a new parametrization

A new approach to the parametrization of the CKM matrix, $V$, is considered in which $V$ is written as a linear combination of the unit matrix $I$ and a non-diagonal matrix $U$ which causes intergenerational-mixing, that is $V=\cos\theta I+i\sin\theta U$. Such a $V$ depends on 3 real parameters including the parameter $\theta$. It is interesting that a value of $\theta=\pi/4$ is required to fit the available data on the CKM-matrix including CP-violation. Predictions of this fit for the angles $\alpha$, $\beta$ and $\gamma$ for the unitarity triangle corresponding to $V_{11}V^*_{13} + V_{21} V^*_{23} +V_{31}V^*_{33} =0$, are given. For $\theta$=$\pi/4$, we obtain $\alpha=88.46^\circ$, $\beta=45.046^\circ$ and $\gamma=46.5^\circ$. These values are just about in agreement, within errors, with the present data. It is very interesting that the unitarity triangle is expected to be approximately a right-angled, isosceles triangle. Our prediction $\sin 2\beta = 1$ is in excellent agreement with the value $0.99\pm 0.15\pm 0.05$ reported by the Belle collaboration at the Lepton-Photon 2001 meeting.Comment: 11 pages, latex, no figure

Fractional statistic

We improve Haldane's formula which gives the number of configurations for $N$ particles on $d$ states in a fractional statistic defined by the coupling $g=l/m$. Although nothing is changed in the thermodynamic limit, the new formula makes sense for finite $N=pm+r$ with $p$ integer and $0<r\leq m.$ A geometrical interpretation of fractional statistic is given in terms of ''composite particles''.Comment: flatex hald.tex, 3 files Submitted to: Phys. Rev.

Confinement and Viscoelastic effects on Chain Closure Dynamics

Chemical reactions inside cells are typically subject to the effects both of the cell's confining surfaces and of the viscoelastic behavior of its contents. In this paper, we show how the outcome of one particular reaction of relevance to cellular biochemistry - the diffusion-limited cyclization of long chain polymers - is influenced by such confinement and crowding effects. More specifically, starting from the Rouse model of polymer dynamics, and invoking the Wilemski-Fixman approximation, we determine the scaling relationship between the mean closure time t_{c} of a flexible chain (no excluded volume or hydrodynamic interactions) and the length N of its contour under the following separate conditions: (a) confinement of the chain to a sphere of radius D, and (b) modulation of its dynamics by colored Gaussian noise. Among other results, we find that in case (a) when D is much smaller than the size of the chain, t_{c}\simND^{2}, and that in case (b), t_{c}\simN^{2/(2-2H)}, H being a number between 1/2 and 1 that characterizes the decay of the noise correlations. H is not known \`a priori, but values of about 0.7 have been used in the successful characterization of protein conformational dynamics. At this value of H (selected for purposes of illustration), t_{c}\simN^3.4, the high scaling exponent reflecting the slow relaxation of the chain in a viscoelastic medium

Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma.

Ewing sarcoma is the second-most-common bone cancer in children. Driven by an oncogenic chromosomal translocation that results in the expression of an aberrant transcription factor, EWS/FLI, the disease is typically aggressive and micrometastatic upon presentation. Silencing of EWS/FLI in patient-derived tumor cells results in the altered expression of hundreds to thousands of genes and is accompanied by dramatic morphological changes in cytoarchitecture and adhesion. Genes encoding focal adhesion, extracellular matrix, and actin regulatory proteins are dominant targets of EWS/FLI-mediated transcriptional repression. Reexpression of genes encoding just two of these proteins, zyxin and α5 integrin, is sufficient to restore cell adhesion and actin cytoskeletal integrity comparable to what is observed when the EWS/FLI oncogene expression is compromised. Using an orthotopic xenograft model, we show that EWS/FLI-induced repression of α5 integrin and zyxin expression promotes tumor progression by supporting anchorage-independent cell growth. This selective advantage is paired with a tradeoff in which metastatic lung colonization is compromised

Thermochemical Studies on Ternary Systems: Part I-Enthalpies of Mixing of Polyoxyethylene Glycols in Aqueous Dioxane & Ethyl Alcohol

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Surgical Management of a Rare Case of Congenital DoubleUpper Lip

Congenital double lip is a rare developmental anomaly which usually involves the upper lip. It may occur in isolation or as a part of Ascher's syndrome. The occurrence of double lip may result in facial deformity especially when patient attempts to talk, smile, or even try to show the teeth. It affects esthetics and also interferes with speech and mastication. Although surgery may be undertaken to facilitate speech and mastication, majority of cases are operated for cosmetic reasons. A case of congenital double upper lip which was surgically treated for cosmetic reason is reported