758 research outputs found
Landslide sites and areas of landslide susceptibility in the town of York, Maine
Maine Geological Survey Open-File Report 09-39.https://digitalmaine.com/mgs_maps/2742/thumbnail.jp
Landslide sites and areas of landslide susceptibility in the town of Kennebunkport, Maine
Maine Geological Survey Open-File Report 09-29.https://digitalmaine.com/mgs_maps/2820/thumbnail.jp
Landslide sites and areas of landslide susceptibility in the towns of Wells and Ogunquit, Maine
Maine Geological Survey Open-File Report 09-38.https://digitalmaine.com/mgs_maps/2809/thumbnail.jp
Qualitative models to predict impacts of human interventions in a wetland ecosystem
The large shallow wetlands that dominate much of the South American continent are rich in biodiversity and complexity. Many of these undamaged ecosystems are presently being examined for their potential economic utility, putting pressure on local authorities and the conservation community to find ways of correctly utilising the available natural resources without compromising the ecosystem functioning and overall integrity. Contrary to many northern hemisphere ecosystems, there have been little long term ecological studies of these systems, leading to a lack of quantitative data on which to construct ecological or resource use models. As a result, decision makers, even well meaning ones, have difficulty in determining if particular economic activities can potentially cause significant damage to the ecosystem and how one should go about monitoring the impacts of such activities. While the direct impact of many activities is often known, the secondary indirect impacts are usually less clear and can depend on local ecological conditions. <br><br> The use of qualitative models is a helpful tool to highlight potential feedback mechanisms and secondary effects of management action on ecosystem integrity. The harvesting of a single, apparently abundant, species can have indirect secondary effects on key trophic and abiotic compartments. In this paper, loop model analysis is used to qualitatively examine secondary effects of potential economic activities in a large wetland area in northeast Argentina, the Esteros del Ibera. Based on interaction with local actors together with observed ecological information, loop models were constructed to reflect relationships between biotic and abiotic compartments. A series of analyses were made to study the effect of different economic scenarios on key ecosystem compartments. Important impacts on key biotic compartments (phytoplankton, zooplankton, ichthyofauna, aquatic macrophytes) and on the abiotic environment (nutrients and sediment resuspension) were observed through model analysis. These models results do not indicate a definite relationship between activity and a possible impact, but a potential impact that can be further studied and modelled. Likewise, the model is not intended to be an end in itself, but as a tool to help focus further ecological study, monitoring and modelling. In the real world of wetland management, it is not always possible to conduct extensive (and expensive) analysis of all the principal ecological compartments. In the same manner, the construction of larger and more complex models for resource management usually needs to be focused to those areas most likely to effect resource quality or ecosystem functioning. In this light, the development of qualitative models was considered as a first step to help researchers and decision makers focus their efforts (and economic resources) in an intensive ecological sampling programme and the construction of predictive models
Observations of water transparency in China's lakes from space
Water transparency, usually denoted by Secchi disk depth (SSD), represents the first-order description of water
quality and has important implications for the diversity and productivity of aquatic life. In China, lakes supply
freshwater and ecosystem services to nearly a billion people. Therefore, real time monitoring of lake transparency
is of great significance. Moreover, understanding how and why transparency varies in space and time in
response to different driving forces is needed to understand, manage, and predict lake water quality. Based on
the time-saving and low-cost Google Earth Engine cloud platform, this study developed a new algorithm for
quickly mapping SDDs in Chinese lakes. SDDs were retrieved for 412 Chinese lakes (> 20 km2) for the period
2000â2018. Results demonstrated that lake water depth spatially differentiated transparency. Deep lakes usually
had high transparency and water depth explained 88.81 % of the spatial variations. With increasing catchment
vegetation coverage and lake water depth, 70.15 % of lakes witnessed increasing transparency during
2000â2018. Of these 42.72 % were significant (p<0.05). Transparency of deep lakes was generally determined
by phytoplankton density not sediment resuspension. Minimum transparency occurred in summer. Future increases
in lake water levels in response to factors such as climate change may contribute to further improvements
in transparency. Management should focus on controlling eutrophication and increasing vegetation cover in
catchments
Pregnancy and Smoothelin-like Protein 1 (SMTNL1) Deletion Promote the Switching of Skeletal Muscle to a Glycolytic Phenotype in Human and Mice
Inter- and intra-observer variability of radial-endobronchial ultrasound image interpretation for peripheral pulmonary lesions
BACKGROUND: Radial probe endobronchial ultrasound (R-EBUS) is often utilized in guided bronchoscopy for the diagnosis of peripheral pulmonary lesions. R-EBUS probe positioning has been shown to correlate with diagnostic yield, but overall diagnostic yield with this technology has been inconsistent across the published literature. Currently there is no standardization for R-EBUS image interpretation, which may result in variability in grading concentricity of lesions and subsequently procedure performance. This was a survey-based study evaluating variability among practicing pulmonologists in R-EBUS image interpretation.
METHODS: R-EBUS images from peripheral bronchoscopy cases were sent to 10 practicing Interventional Pulmonologists at two different time points (baseline and 3 months). Participants were asked to grade the images as concentric, eccentric, or no image. Cohen\u27s Kappa-coefficient was calculated for inter- and intra-observer variability.
RESULTS: A total of 100 R-EBUS images were included in the survey. There was 100% participation with complete survey responses from all 10 participants. Overall kappa-statistic for inter-observer variability for Survey 1 and 2 was 0.496 and 0.477 respectively. Overall kappa-statistic for intra-observer variability between the two surveys was 0.803.
CONCLUSIONS: There is significant variability between pulmonologists when characterizing R-EBUS images. However, there is strong intra-rater agreement from each participant between surveys. A standardized approach and grading system for radial EBUS patterns may improve inter-observer variability in order to optimize our clinical use and research efforts in the field
Selective Roles for Tumor Necrosis Factor α-converting Enzyme/ADAM17 in the Shedding of the Epidermal Growth Factor Receptor Ligand Family: THE JUXTAMEMBRANE STALK DETERMINES CLEAVAGE EFFICIENCY
Epidermal growth factor (EGF) family ligands are derived by proteolytic cleavage of the ectodomains of integral membrane precursors. Previously, we established that tumor necrosis factor alpha-converting enzyme (TACE/ADAM17) is a physiologic transforming growth factor-alpha (TGF-alpha) sheddase, and we also demonstrated enhanced shedding of amphiregulin (AR) and heparin-binding (HB)-EGF upon restoration of TACE activity in TACE-deficient EC-2 fibroblasts. Here we extended these results by showing that purified soluble TACE cleaved single sites in the juxtamembrane stalks of mouse pro-HB-EGF and pro-AR ectodomains in vitro. For pro-HB-EGF, this site matched the C terminus of the purified human growth factor, and we speculate that the AR cleavage site is also physiologically relevant. In contrast, ADAM9 and -10, both implicated in HB-EGF shedding, failed to cleave the ectodomain or cleaved at a nonphysiologic site, respectively. Cotransfection of TACE in EC-2 cells enhanced phorbol myristate acetate-induced but not constitutive shedding of epiregulin and had no effect on betacellulin (BTC) processing. Additionally, soluble TACE did not cleave the juxtamembrane stalks of either pro-BTC or pro-epiregulin ectodomains in vitro. Substitution of the shorter pro-BTC juxtamembrane stalk or truncation of the pro-TGF-alpha stalk to match the pro-BTC length reduced TGF-alpha shedding from transfected cells to background levels, whereas substitution of the pro-BTC P2-P2' sequence reduced TGF-alpha shedding less dramatically. Conversely, substitution of the pro-TGF-alpha stalk or lengthening of the pro-BTC stalk, especially when combined with substitution of the pro-TGF-alpha P2-P2' sequence, markedly increased BTC shedding. These results indicate that efficient TACE cleavage is determined by a combination of stalk length and scissile bond sequence
Creating space for citizenship : the impact of group structure on validating the voices of people with dementia
This is the authorâs version of a work that was accepted for publication in the journal Dementia. The publisher's version is available at doi:10.1177/1471301216642339 (Sage)Recently, there has been increasing attention given to finding ways to help people
diagnosed with dementia âlive wellâ with their condition. Frequently however, the
attention has been placed on the family care partner as the foundation for creating a
context that supports the person with dementia to live well. A recent participatory action
research (PAR) study highlighted the importance of beginning to challenge some of the
assumptions around how best to include family, especially within a context of supporting
citizenship. Three advisory groups consisting of 20 people with dementia, 16 care
partners, and 3 service providers, were set up in three locations across Canada to help
develop a self-management program for people with dementia. The hubs met monthly for
up to two years. One of the topics that emerged as extremely important to consider in
the structuring of the program revolved around whether or not these groups should be
segregated to include only people with dementia. A thematic analysis of these ongoing
discussions coalesced around five inter-related themes: creating safe spaces;
maintaining voice and being heard; managing the balancing act; and the importance of
solidarity. Underpinning these discussions was the fifth theme, recognition that âone
size doesnât fit allâ. Overall an important finding was that the presence of family carepartners
could have unintended consequences in relation to creating the space for active
citizenship to occur in small groups of people with dementia although it could also offer
some opportunities. The involvement of care partners in groups with people with
dementia is clearly one that is complex without an obvious answer and dependent on a
variety of factors to inform a solution, which can and should be questioned and revisited
Narrow genetic base in forest restoration with holm oak (Quercus ilex L.) in Sicily
In order to empirically assess the effect of actual seed sampling strategy on
genetic diversity of holm oak (Quercus ilex) forestations in Sicily, we have
analysed the genetic composition of two seedling lots (nursery stock and
plantation) and their known natural seed origin stand by means of six nuclear
microsatellite loci. Significant reduction in genetic diversity and significant
difference in genetic composition of the seedling lots compared to the seed
origin stand were detected. The female and the total effective number of
parents were quantified by means of maternity assignment of seedlings and
temporal changes in allele frequencies. Extremely low effective maternity
numbers were estimated (Nfe 2-4) and estimates accounting for both
seed and pollen donors gave also low values (Ne 35-50). These values
can be explained by an inappropriate forestry seed harvest strategy limited to
a small number of spatially close trees
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