Implications of the experimental results on high energy cosmic rays with regard to their origin

It was shown in an earlier report that current cosmic ray evidence supports a change in the cosmic ray composition in the region between 10 to the 6th power and 10 to the 8th power GeV total energy in the direction of a smaller average value of A. Compared to normal celestial abundances, the heavy nuclei are much less abundant, and, in fact, the composition measurements above 10 to the 8th power GeV are consistent with there being only protons. Here, these results combined with those of the energy spectrum and anisotropy of the comsic rays and other astrophysical information will be examined to try to determine their implications for the origin of the cosmic rays. In this paper, consideration is given to the implications of one or more than one type of source in the galaxy to see which are consistent with the interpretation of current measurements. The nature of the source types that would be required are discussed

Energy dependence of cosmic ray composition above 10(15) GeV/nucleus

It is argued that above 10 to the 5th power GeV/nucleus, in the range where charge-resolved spectra have not yet been determined, the appropriate measures of equal-energy composition are 1nA and 1nA , the mean value and dispersion relative to the mean value and dispersion relative to the mean of 1nA, where A is the mass number. Experimental data which are sensitive to changes in 1nA with increasing energy are examined. It is found that, taken as a whole, they show no change (+ or 0.5) between 10 to the 5th power and 10 to the 6th power GeV, and a decrease of 1.5 + or - 0.5 between 10 to the 6th power and 10 to the 8th power GeV, with no further change + or - 0.5) above 10 to the 8th power GeV. Taken as a whole, the various indirect estimates of the absolute value of 1nA above 10 to the 5th power GeV/nucleus are also consistent with this pattern. For a wide range of astrophysically plausible composition models the value of the other measure, 1nA is insensitive to changes in 1nA . Because of this the existing data on 1nA can likewise easily be reconciled with this pattern

Photocurable Bioink for the Inkjet 3D Pharming of Hydrophilic Drugs.

Novel strategies are required to manufacture customized oral solid dosage forms for personalized medicine applications. 3D Pharming, the direct printing of pharmaceutical tablets, is an attractive strategy, since it allows for the rapid production of solid dosage forms containing custom drug dosages. This study reports on the design and characterization of a biocompatible photocurable pharmaceutical polymer for inkjet 3D printing that is suitable for hydrophilic active pharmaceutical ingredients (API). Specifically, hyaluronic acid was functionalized with norbornene moieties that, in the presence of poly(ethylene) glycol dithiol, Eosin Y as a photoinitiator, and a visible light source, undergoes a rapid step-growth polymerization reaction through thiol-ene chemistry. The engineered bioink was loaded with Ropinirole HCL, dispensed through a piezoelectric nozzle onto a blank preform tablet, and polymerized. Drug release analysis of the tablet resulted in 60% release within 15 min of tablet dissolution. The study confirms the potential of inkjet printing for the rapid production of tablets through the deposition of a photocurable bioink designed for hydrophilic APIs

Tropical–North Pacific Climate Linkages over the Past Four Centuries

Analyses of instrumental data demonstrate robust linkages between decadal-scale North Pacific and tropical Indo-Pacific climatic variability. These linkages encompass common regime shifts, including the noteworthy 1976 transition in Pacific climate. However, information on Pacific decadal variability and the tropical high-latitude climate connection is limited prior to the twentieth century. Herein tree-ring analysis is employed to extend the understanding of North Pacific climatic variability and related tropical linkages over the past four centuries. To this end, a tree-ring reconstruction of the December-May North Pacific index (NPI)-an index of the atmospheric circulation related to the Aleutian low pressure cell-is presented (1600-1983). The NPI reconstruction shows evidence for the three regime shifts seen in the instrumental NPI data, and for seven events in prior centuries. It correlates significantly with both instrumental tropical climate indices and a coral-based reconstruction of an optimal tropical Indo-Pacific climate index, supporting evidence for a tropical-North Pacific link extending as far west as the western Indian Ocean. The coral-based reconstruction (1781-1993) shows the twentieth-century regime shifts evident in the instrumental NPI and instrumental tropical Indo-Pacific climate index, and three previous shifts. Changes in the strength of correlation between the reconstructions over time, and the different identified shifts in both series prior to the twentieth century, suggest a varying tropical influence on North Pacific climate, with greater influence in the twentieth century. One likely mechanism is the low-frequency variability of the El Nino-Southern Oscillation (ENSO) and its varying impact on Indo-Pacific climate.</p

Resummed Quantum Gravity

We present the current status of the a new approach to quantum general relativity based on the exact resummation of its perturbative series as that series was formulated by Feynman. We show that the resummed theory is UV finite and we present some phenomenological applications as well.Comment: 4 pages, 1 figure; presented at ICHEP0

Ultra high energy neutrinos from gamma ray bursts

Protons accelerated to high energies in the relativistic shocks that generate gamma ray bursts photoproduce pions, and then neutrinos in situ. I show that ultra high energy neutrinos (> 10^19 eV) are produced during the burst and the afterglow. A larger flux, also from bursts, is generated via photoproduction off CMBR photons in flight but is not correlated with currently observable bursts, appearing as a bright background. Adiabatic/synchrotron losses from protons/pions/muons are negligible. Temporal and directional coincidences with bursts detected by satellites can separate correlated neutrinos from the background.Comment: Adiabatic/synchrotron losses from protons/pions/muons shown to be negligible. Accepted for publication in Phys. Rev. Letters. RevTe

On the Discovery of the GZK Cut-off

The recent claim of the '5 sigma' observation of the Greisen and Zatzepin and Kuzmin cut-off by the HiRes group based on their nine years data is a significant step toward the eventual solution of the one of the most intriguing questions which has been present in physics for more than forty years. However the word 'significance' is used in the mentioned paper in the sense which is not quite obvious. In the present paper we persuade that this claim is a little premature.Comment: 10 page

The energy spectrum observed by the AGASA experiment and the spatial distribution of the sources of ultra-high energy cosmic rays

Seven and a half years of continuous monitoring of giant air showers triggered by ultra high-energy cosmic rays have been recently summarized by the AGASA collaboration. The resulting energy spectrum indicates clearly that the cosmic ray spectrum extends well beyond the Greisen-Zatsepin-Kuzmin (GZK) cut-off at $\sim 5 \times 10^{19}$ eV. Furthermore, despite the small number statistics involved, some structure in the spectrum may be emerging. Using numerical simulations, it is demonstrated in the present work that these features are consistent with a spatial distribution of sources that follows the distribution of luminous matter in the local Universe. Therefore, from this point of view, there is no need for a second high-energy component of cosmic rays dominating the spectrum beyond the GZK cut-off.Comment: 14 pages, 4 figures, Astrophys. J. Letters (submitted