Quantitative Analysis of Electrotonic Structure and Membrane Properties of NMDA-Activated Lamprey Spinal Neurons

Parameter optimization methods were used to quantitatively analyze frequency-domain-voltage-clamp data of NMDA-activated lamprey spinal neurons simultaneously over a wide range of membrane potentials. A neuronal cable model was used to explicitly take into account receptors located on the dendritic trees. The driving point membrane admittance was measured from the cell soma in response to a Fourier synthesized point voltage clamp stimulus. The data were fitted to an equivalent cable model consisting of a single lumped soma compartment coupled resistively to a series of equal dendritic compartments. The model contains voltage-dependent NMDA sensitive (INMDA), slow potassium (IK), and leakage (IL) currents. Both the passive cable properties and the voltage dependence of ion channel kinetics were estimated, including the electrotonic structure of the cell, the steady-state gating characteristics, and the time constants for particular voltage- and time-dependent ionic conductances. An alternate kinetic formulation was developed that consisted of steady-state values for the gating parameters and their time constants at half-activation values as well as slopes of these parameters at half-activation. This procedure allowed independent restrictions on the magnitude and slope of both the steady-state gating variable and its associated time constant. Quantitative estimates of the voltage-dependent membrane ion conductances and their kinetic parameters were used to solve the nonlinear equations describing dynamic responses. The model accurately predicts current clamp responses and is consistent with experimentally measured TTX-resistant NMDA-induced patterned activity. In summary, an analysis method is developed that provides a pragmatic approach to quantitatively describe a nonlinear neuronal system

Sharing Ownership via Employee Stock Ownership

Broad-based stock options, Employee ownership, Incentive compensation,

Results from the LSND Neutrino Oscillation Search

The Liquid Scintillator Neutrino Detector (LSND) at the Los Alamos Meson Physics Facility sets bounds on neutrino oscillations in the appearance channel nu_mu_bar --> nu_e_bar by searching for the signature of the reaction nu_e_bar p --> e^+ n: an e$^+$ followed by a 2.2MeV gamma ray from neutron capture. Five e^{+/-} -- gamma coincidences are observed in time with the LAMPF beam, with an estimated background of 6.2 events. The 90\% confidence limits obtained are: Delta (m^2) < 0.07eV^2 for sin^2 (2theta) = 1, and sin^2(2theta) < 6 10^{-3} for Delta (m^2) > 20 eV^2.Comment: 10 pages, uses REVTeX and epsf macro

RISK AND SUSTAINABLE AGRICULTURE: A TARGET-MOTAD ANALYSIS OF THE 92-YEAR "OLD ROTATION"

Target-MOTAD was used to assess the risks and returns of sustainable cotton crop rotations from Auburn University's 92-year "Old Rotation." Study results analyze rotations of continuous cotton, with and without winter legumes; two years of cotton-winter legumes-corn, with and without nitrogen fertilization; and three years of cotton-winter legumes-corn and rye-soybeans double-cropped. Ten years of observations on deviations from target income were used to identify optimal sustainable rotation(s). Study results suggest that diversification in rotations, as well as in crops, results in the least risk for a given level of target income.Risk and Uncertainty,

Outstanding Educational Performance Awards: Highlighting High Achieving Arkansas Schools, 2010

So, in this Arkansas Education Report (AER) we aim to highlight excellent performance and give our congratulations. To that end, we are happy to highlight many high performing schools around the state in our now-annual AER entitled the Outstanding Educational Performance Awards

Nano-porosity in GaSb induced by swift heavy ion irradiation

Nano-porous structures form in GaSb after ion irradiation with 185 MeV Au ions. The porous layer formation is governed by the dominant electronic energy loss at this energy regime. The porous layer morphology differs significantly from that previously reported for low-energy, ion-irradiated GaSb. Prior to the onset of porosity, positron annihilation lifetime spectroscopy indicates the formation of small vacancy clusters in single ion impacts, while transmission electron microscopy reveals fragmentation of the GaSb into nanocrystallites embedded in an amorphous matrix. Following this fragmentation process, macroscopic porosity forms, presumably within the amorphous phase.The authors thank the Australian Research Council for support and the staff at the ANU Heavy Ion Accelerator Facility for their continued technical assistance. R.C.E. acknowledges the support from the Office of Basic Energy Sciences of the U.S. DOE (Grant No. DE-FG02-97ER45656)

COMPLIANCE TESTING OF IOWA’S SKID-MOUNTED SIGN DEVICE

A wide variety of traffic control devices are used in work zones, some of which are nont ormally found on the roadside or in the traveled way outsideofthe work zones. These devices are used to enhance the safety of the work zones by controlling the traffic through these areas. Due to the placement of the traffic control devices, the devices themselves may be potentially hazardous to both workers and errant vehicles. The impact performance of many work zone traffic control devices is mainly unknown and to date limited crash testing has been conducted under the criteria of National Cooperative Highway Research Program (NCHRP) Report No. 350, Recommended Procedures for the Safety Performance Evaluation of Highway Features. The objective of the study was to evaluatethe safety performance of existing skid-mounted sign supports through full- scale crash testing. Two full-scale crash tests were conducted on skid-mounted sign supports to determine their safety performance according to the Test Level 3 (TL-3) criteria set forth in the NCHRP Report No. 350. The safety performancevaluations indicate that these skid-mounted sign supports did not perform satisfactorily in the full-scale crash tests. The results of the crash tests were documented, and conclusions and recommendations pertaining tothe safety performance of the existing work zone traffic control devices were made