81 research outputs found

    Single crystal structure, solid state characterization and dissolution rate of terbinafine hydrochloride

    No full text
    Terbinafine hydrochloride (TH), a poorly water soluble antifungal agent, was characterized by solid state techniques including differential scanning calorimetry, thermogravimetry, X-ray powder diffraction, optical and electron microscopies, Fourier transform infrared, Raman and solid-state nuclear magnetic resonance spectroscopies and intrinsic dissolution rate (IDR). A colorless single crystal of TH was grown from an ethanol:water solution and its crystalline structure was determined through X-ray single crystal diffraction. Also, a new crystal habit of TH was obtained through the slow solvent evaporation technique revealing a needle-like shape. A comparison between the IDR results for the TH raw material and TH needle-like crystal revealed lower values for the new crystal habit, which can be attributed to the preferential orientation of the crystals in the compressed disks.Fil: Kuminek, Gislaine. Universidade Federal de Santa Catarina; BrasilFil: Rauber, Gabriela Schneider. Universidade Federal de Santa Catarina; BrasilFil: Riekes, Manoela KlĂĽppel. Universidade Federal de Santa Catarina; BrasilFil: Campos, Carlos Eduardo Maduro de. Universidade Federal de Santa Catarina; BrasilFil: Monti, Gustavo Alberto. Consejo Nacional de Investigaciones CientĂ­ficas y TĂ©cnicas. Centro CientĂ­fico TecnolĂłgico Conicet - CĂłrdoba. Instituto de FĂ­sica Enrique Gaviola. Universidad Nacional de CĂłrdoba. Instituto de FĂ­sica Enrique Gaviola; ArgentinaFil: Bortoluzzi, Adailton JoĂŁo. Universidade Federal de Santa Catarina; BrasilFil: Cuffini, Silvia Lucia. Consejo Nacional de Investigaciones CientĂ­ficas y TĂ©cnicas; Argentina. Universidade Federal de Santa Catarina; BrasilFil: Cardoso, Simone Goncalves. Universidade Federal de Santa Catarina; Brasi

    Francisella tularensis aortitis

    No full text
    International audienceFrancisella tularensis, the agent of tularemia, is a Gram-negative coccobacillus primarily pathogen for animals and occasionally for humans. The clinical manifestations of tularemia include pneumonia, ulceroglandular, oropharyngeal, or typhoidal disease. Rare manifestations are also described, but to our knowledge, we describe here the first case of F. tularensis aortitis in a human. Diagnosis was confirmed by the presence of F. tularensis in blood culture, by the presence of F. tularensis DNA in the aortic biopsy and by specific IgG and IgM responses against the bacteria. The outcome was favorable after surgery and specific antimicrobial therapy
    • …
    corecore