4,279 research outputs found
Anisotropic imbibition on surfaces patterned with polygonal posts
We present and interpret lattice Boltzmann simulations of thick films
spreading on surfaces patterned with polygonal posts. We show that the
mechanism of pinning and depinning differs with the direction of advance, and
demonstrate that this leads to anisotropic spreading within a certain range of
material contact angles.Comment: DSFD Proceedings 201
Matrix Big Brunch
Following the holographic description of linear dilaton null Cosmologies with
a Big Bang in terms of Matrix String Theory put forward by Craps, Sethi and
Verlinde, we propose an extended background describing a Universe including
both Big Bang and Big Crunch singularities. This belongs to a class of exact
string backgrounds and is perturbative in the string coupling far away from the
singularities, both of which can be resolved using Matrix String Theory. We
provide a simple theory capable of describing the complete evolution of this
closed Universe.Comment: 15 pages, no figures. References adde
Recommended from our members
Protein Tyrosine Phosphatase-1B (PTP1B) Helps Regulate EGF-induced Stimulation of S-phase Entry in Human Corneal Endothelial Cells
Purpose: Human corneal endothelial cells (HCEC), particularly from older donors, only proliferate weakly in response to EGF. The protein tyrosine phosphatase, PTP1B, is known to negatively regulate EGF-induced signaling in several cell types by dephosphorylating the epidermal growth factor receptor (EGFR). The current studies were conducted to determine whether PTP1B plays a role in regulating cell cycle entry in HCEC in response to EGF stimulation. Methods: Donor corneas were obtained from the National Disease Research Interchange and accepted for study based on established exclusion criteria. PTP1B was localized in the endothelium of ex vivo corneas and in cultured cells by immunocytochemistry. Western blot analysis verified PTP1B protein expression in HCEC and then compared the relative expression of EGFR and PTP1B in HCEC from young (60 years old). The effect of inhibiting the activity of PTP1B on S-phase entry was tested by comparing time-dependent BrdU incorporation in subconfluent HCEC incubated in the presence or absence of the PTP1B inhibitor, CinnGEL 2Me, before EGF stimulation. Results: PTP1B was localized in a punctate pattern mainly within the cytoplasm of HCEC in ex vivo corneas and cultured cells. Western blots revealed the presence of three PTP1B-positive bands in HCEC and the control. Further western blot analysis showed no significant age-related difference in expression of EGFR (p=0.444>0.05); however, PTP1B expression was significantly higher in HCEC from older donors (p=0.024<0.05). Pre-incubation of HCEC with the PTP1B inhibitor significantly increased (p=0.019<0.05) the number of BrdU positive cells by 48 h after EGF stimulation. Conclusions: Both immunolocalization and western blot studies confirmed that PTP1B is expressed in HCEC. Staining patterns strongly suggest that at least a subset of PTP1B is localized to the cytoplasm and most likely to the endoplasmic reticulum, the known site of EGFR/PTP1B interaction following EGF stimulation. PTP1B expression, but not EGFR expression, was elevated in HCEC from older donors, suggesting that the reduced proliferative activity of these cells in response to EGF is due, at least in part, to increased PTP1B activity. The fact that inhibition of PTP1B increased the relative number of cells entering S-phase strongly suggests that PTP1B helps negatively regulate EGF-stimulated cell cycle entry in HCEC. These results also suggest that it may be possible to increase the proliferative activity of HCEC, particularly in cells from older donors, by inhibiting the activity of this important protein tyrosine phosphatase
Dynamics of the spontaneous breakdown of superhydrophobicity
Drops deposited on rough and hydrophobic surfaces can stay suspended with gas
pockets underneath the liquid, then showing very low hydrodynamic resistance.
When this superhydrophobic state breaks down, the subsequent wetting process
can show different dynamical properties. A suitable choice of the geometry can
make the wetting front propagate in a stepwise manner leading to {\it
square-shaped} wetted area: the front propagation is slow and the patterned
surface fills by rows through a {\it zipping} mechanism. The multiple time
scale scenario of this wetting process is experimentally characterized and
compared to numerical simulations.Comment: 7 pages, 5 figure
[O III] and X-ray Properties of a Complete Sample of Hard X-ray Selected AGNs in the Local Universe
We study the correlation between the [O III] and X-ray
luminosities of local Active Galactic Nuclei (AGNs), using a complete, hard
X-ray ( keV) selected sample in the Swift/BAT 9-month catalog. From our
optical spectroscopic observations at the South African Astronomical
Observatory and the literature, a catalog of [O III] line flux
for all 103 AGNs at Galactic latitudes of is complied.
Significant correlations with intrinsic X-ray luminosity () are
found both for observed () and extinction-corrected () luminosities, separately for X-ray unabsorbed and absorbed
AGNs. We obtain the regression form of and from the whole sample. The absorbed AGNs with low
(0.5\%) scattering fractions in soft X-rays show on average smaller and ratios than the
other absorbed AGNs, while those in edge-on host galaxies do not. These results
suggest that a significant fraction of this population are buried in tori with
small opening angles. By using these vs.
correlations, the X-ray luminosity function of local AGNs (including Compton
thick AGNs) in a standard population synthesis model gives much better
agreement with the [O III] luminosity function derived from the
Sloan Digital Sky Survey than previously reported. This confirms that hard
X-ray observations are a very powerful tool to find AGNs with high
completeness.Comment: 14 pages including 11 figures and 3 tables, accepted for publication
in ApJ. In this manuscript, the observed 14-195 keV luminosities in Table 1
have been corrected to be exactly the same as in the original Swift/BAT
9-month catalog. Accordingly, Figures 2(a) and 3(a) and a part of Tables 2
and 3 have been updated. The changes from the previous version are small and
do not affect the tex
Intersecting black branes in strong gravitational waves
We consider intersecting black branes with strong gravitational waves
propagating along their worldvolume in the context of supergravity theories.
Both near-horizon and space-filling gravitational wave modes are included in
our ansatz. The equations of motion (originally, partial differential
equations) are shown to reduce to ordinary differential equations, which
include a Toda-like system. For special arrangements of intersecting black
branes, the Toda-like system becomes integrable, permitting a more thorough
analysis of the gravitational equations of motion.Comment: 17 pages; v2: cosmetic improvements, published versio
A trans-homologue interaction between reciprocally imprinted miR-127 and Rtl1 regulates placenta development.
The paternally expressed imprinted retrotransposon-like 1 (Rtl1) is a retrotransposon-derived gene that has evolved a function in eutherian placentation. Seven miRNAs, including miR-127, are processed from a maternally expressed antisense Rtl1 transcript (Rtl1as) and regulate Rtl1 levels through RNAi-mediated post-transcriptional degradation. To determine the relative functional role of Rtl1as miRNAs in Rtl1 dosage, we generated a mouse specifically deleted for miR-127. The miR-127 knockout mice exhibit placentomegaly with specific defects within the labyrinthine zone involved in maternal-fetal nutrient transfer. Although fetal weight is unaltered, specific Rtl1 transcripts and protein levels are increased in both the fetus and placenta. Phenotypic analysis of single (ΔmiR-127/Rtl1 or miR-127/ΔRtl1) and double (ΔmiR-127/ΔRtl1) heterozygous miR-127- and Rtl1-deficient mice indicate that Rtl1 is the main target gene of miR-127 in placental development. Our results demonstrate that miR-127 is an essential regulator of Rtl1, mediated by a trans-homologue interaction between reciprocally imprinted genes on the maternally and paternally inherited chromosomes.This work was supported by the Biotechnology and Biological Sciences Research Council (BBSRC) and Medical Research Council (MRC) and EU FP7 Marie Curie Action 290123 (INGENIUM). This work was partly funded by a National Health and Medical Research Council (NHMRC) CJ Martin Biomedical Fellowship to A.N.S.P.This is the accepted manuscript. The final version is available at http://dev.biologists.org/content/early/2015/07/01/dev.121996.abstract
Binary Quantum Turbulence Arising from Countersuperflow Instability in Two-Component Bose-Einstein Condensates
We theoretically study the development of quantum turbulence from two
counter-propagating superfluids of miscible Bose-Einstein condensates by
numerically solving the coupled Gross-Pitaevskii equations. When the relative
velocity exceeds a critical value, the counter-superflow becomes unstable and
quantized vortices are nucleated, which leads to isotropic quantum turbulence
consisting of two superflows. It is shown that the binary turbulence can be
realized experimentally in a trapped system.Comment: 5 pages, 3 figure
Retrotransposon Silencing by DNA Methylation Can Drive Mammalian Genomic Imprinting
Among mammals, only eutherians and marsupials are viviparous and have genomic imprinting that leads to parent-of-origin-specific differential gene expression. We used comparative analysis to investigate the origin of genomic imprinting in mammals. PEG10 (paternally expressed 10) is a retrotransposon-derived imprinted gene that has an essential role for the formation of the placenta of the mouse. Here, we show that an orthologue of PEG10 exists in another therian mammal, the marsupial tammar wallaby (Macropus eugenii), but not in a prototherian mammal, the egg-laying platypus (Ornithorhynchus anatinus), suggesting its close relationship to the origin of placentation in therian mammals. We have discovered a hitherto missing link of the imprinting mechanism between eutherians and marsupials because tammar PEG10 is the first example of a differentially methylated region (DMR) associated with genomic imprinting in marsupials. Surprisingly, the marsupial DMR was strictly limited to the 5′ region of PEG10, unlike the eutherian DMR, which covers the promoter regions of both PEG10 and the adjacent imprinted gene SGCE. These results not only demonstrate a common origin of the DMR-associated imprinting mechanism in therian mammals but provide the first demonstration that DMR-associated genomic imprinting in eutherians can originate from the repression of exogenous DNA sequences and/or retrotransposons by DNA methylation
- …